Les Écritures du « je » en recherche-création: De possibles anti-projets ?

International audienceWhilst the idea of a project would appear to assume what the object of the thesis will presume as the thesis' final form and purpose, in research-creation this notion is sometimes challenged. In what way does this type of research question the notion of project, in its sometimes contradictory link to the future? Research-creation requires us to witness the processes that inhabit us, as we become observers and creators. Focus turns towards thought movements, while momentarily abandoning the end result. Naturally, deviating is part of any research work; the difference lies in the valorization of mechanisms that normally remain hidden, as material for thinking. Through the study of two literary works, De Cendres et de braises (2019) by Manon Ott, and of xx.com (2020) by Jean Gilbert, I wish to show that research-creation, in particular in literature, allows us to consider becoming, with its own configurations.Si le projet semble présumer l’objet que sera la thèse, en recherche-création cette notion est parfois mise à mal. En quoi cette forme de recherche interroge le projet, dans son lien parfois contradictoire avec le devenir ? La recherche-création demande de se rendre témoin des processus qui nous habitent, nous devenons observateurs ou observatrices et créateurs ou créatrices. La focale se tourne vers les mouvements de pensée, et délaisse momentanément le résultat. Naturellement la dérive fait partie de tout travail de recherche. La différence se trouve dans la valorisation des mécanismes qui restent normalement caches, comme matière à penser. À travers l’étude de De Cendres en de braises (2019) de Manon Ott, et de xx.com (2020) de Jean Gilbert, je souhaite montrer que la recherche-création, en particulier en littérature, permet d’envisager le devenir avec ses configurations propres

Hyperperformer le stéréotype : l’écriture d’une scène de sexe dans The Compleat Purge de Trisha Low

“Vol. II: The sexual assault of Trisha Low as circulated by love in a maze, or, virtue rewarded” is the title of the second part of The Compleat Purge, a poetic text published in 2013 by Trisha Low. It is emblematic of the way in which North-American post-conceptualist poets have seized their conceptualist heritage: they appropriate the words of others in order to reproduce them, to copy them, to pastiche them, in an impure way. In this section, Low evokes, summons, and pastiches different literary genres that formulate female sexuality, and thus say something about the gender identity that is supposed to conform to these practices. Low cites these literary discourses in a way that emphasizes their stereotypical nature, including cliché dialogues and a sex scene written as an adolescent fantasy. This is exactly why Low’s strategy is situated. She is not trying to subvert dominant cultural representations. On the contrary, she is exaggerating them. Her practice performs a form of hyper-identification with the very cultural and aesthetic codes she pastiches. As opposed to aiming at another type of representation separated from the dominant masculine ideology, her strategy aims rather at exaggerating normative scripts – an exaggeration which ends up in exhausting them

Plaquette sanguine et sclérodermie systémique (place du vascular endothelial growth factor plaquettaire dans la dérégulation de l'angiogénèse chez les patients sclérodermiques)

L'altération de l'angiogénèse est une caractéristique essentielle dans la sclérodermie systémique (ScS) mais son mécanisme reste incompris. Les plaquettes sanguines pourraient jouer un rôle important dans la dérégulation de l'activité angiogénique au niveau du lit vasculaire dans la ScS par leur capacité a sécréter des facteurs de croissance pro- et anti-angiogéniques...AMIENS-BU Santé (800212102) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

In Vivo Studies of Translational Repression Mediated by the Granulocyte-Macrophage Colony-stimulating Factor AU-rich Element

International audienceThe AU-rich element (ARE) controls the turnover of many unstable mRNAs and their translation. The granulocyte-macrophage colony-stimulating factor (GM-CSF) ARE is known to be a destabilizing element, but its role in translation remains unclear. Here we studied in vivo the role of the GM-CSF ARE on the mRNA and protein expressions of an enhanced green fluorescent protein reporter gene. The GM-CSF ARE had a repressor effect on translation independently of its effect on mRNA levels. In the context of an internal ribosome entry site, the GM-CSF ARE still repressed translation but was no longer functional as a destabilizing element. Gel retardation assays showed that poly(A)-binding protein is displaced from the poly(A) tail when the ARE is present in the 3'-untranslated region. These data suggest that the GM-CSF ARE controls translation and mRNA decay by interfering with poly(A)-binding protein-mediated mRNA circularization

Flt3-ligand induces adhesion of haematopoietic progenitor cells via a very late antigen (VLA)-4- and VLA-5-dependent mechanism

International audienceThe adhesion of haematopoietic progenitor cells (HPC) to the bone marrow microenvironment is a process regulated by cytokines. In this study, we have shown that flt3-ligand (FL), a growth factor that controls early haematopoiesis, regulated the function and expression of the beta-1 integrins, very late antigen (VLA)-4 and VLA-5 on HPC. The modulation of the adhesiveness of HPC by FL was studied by adhesion assays on umbilical vein endothelial cells (HUVEC). Stimulation by FL induced two peaks of increased adhesiveness of HPC. The first peak was at around 30 min and was mechanistically related to an activation of the beta-1 integrins, mainly VLA-4 and VLA-5. The second peak was at around 12 h and was related to increased expression of VLA-4 and VLA-5. The control of HPC adhesiveness by FL is a previously unreported property of FL that may be important for the homing and the retention of flt3-expressing HPC within the bone marrow microenvironment

Projet, Projeter, Projection

International audienceOn 30 November 2021, the doctoral researchers of the Doctoral School 31 Practices and Theories of Meaning of the University of Paris 8 Vincennes - Saint-Denis organised a study day on the theme "Project, Projecting, Projection". This book gathers seven articles resulting from these academic exchanges, gathered in order to offer an inter- and transdisciplinary view of the different notions related to the project, apprehended as a research subject and as a methodological tool.Le 30 novembre 2021, les chercheur·se·s doctorant·e·s de l’École Doctorale 31 Pratiques et théories du sens de l’Université Paris 8 Vincennes – Saint-Denis ont organisé une journée d’études ayant pour thème « Projet, Projeter, Projection ». Cet ouvrage qui en émane rassemble sept articles issus de ces échanges académiques, rassemblés afin d’offrir une vison inter- et transdisciplinaire des différentes notions relatives au projet, appréhendé comme sujet de recherche et comme outil méthodologique

In Vivo MR Imaging of Intravascularly Injected Magnetically Labeled Mesenchymal Stem Cells in Rat Kidney and Liver

International audienceTo evaluate in vivo magnetic resonance (MR) imaging with a conventional 1.5-T system for depiction and tracking of intravascularly injected superparamagnetic iron oxide (SPIO)-labeled mesenchymal stem cells (MSCs)

Increased soluble and platelet-associated CD40 ligand in essential thrombocythemia and reactive thrombocytosis

International audienceCD40 ligand (CD40L) is expressed on activated CD4(+) T lymphocytes and at the activated platelet surface. A circulating soluble form of CD40L (sCD40L) is generated by the way of a proteolytic cleavage. We measured sCD40L in the plasma of either healthy subjects; patients with inflammatory disorders and low, normal, or high platelet count (reactive thrombocytosis); or patients with essential thrombocythemia (ET). A tight correlation was found between the platelet count and plasma sCD40L. ET patients had the highest levels of sCD40L. Platelet-associated CD40L was increased in ET and reactive thrombocytosis, conditions associated with increased platelet regeneration. Platelet-associated CD40L was released upon platelet activation. In conclusion, platelets appear as a reservoir of CD40L that may be a major contributor to circulating sCD40L. Platelet-associated CD40L may be a potential marker of platelet regeneration