Dataset of herbarium specimens of threatened vascular plants in Catalonia

This data paper describes a specimens' dataset of the Catalonian threatened vascular plants conserved in five public Catalonian herbaria (BC, BCN, HGI, HBIL and MTTE). Catalonia is an administrative region of Spain that includes large autochthon plants diversity and 199 taxa with IUCN threatened categories (EX, EW, RE, CR, EN and VU). This dataset includes 1,618 records collected from 17th century to nowadays. For each specimen, the species name, locality indication, collection date, collector, ecology and revision label are recorded. More than 94% of the taxa are represented in the herbaria, which evidence the paper of the botanical collections as an essential source of occurrence data

Gene therapy for overexpressing Neuregulin 1 type I in skeletal muscles promotes functional improvement in the SOD1G93A ALS mice

Altres ajuts: Fundació La Marato-TV3: TV3201428-10 ; AFM-Telethon: 20289Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder affecting motoneurons (MNs), with no effective treatment currently available. The molecular mechanisms that are involved in MN death are complex and not fully understood, with partial contributions of surrounding glial cells and skeletal muscle to the disease. Neuregulin 1 (NRG1) is a trophic factor highly expressed in MNs and neuromuscular junctions. Recent studies have suggested a crucial role of the isoform I (NRG1-I) in the collateral reinnervation process in skeletal muscle, and NRG1-III in the preservation of MNs in the spinal cord, opening a window for developing novel therapies for neuromuscular diseases like ALS. In this study, we overexpressed NRG1-I widely in the skeletal muscles of the SOD1G93A transgenic mouse. The results show that NRG1 gene therapy activated the survival pathways in muscle and spinal cord, increasing the number of surviving MNs and neuromuscular junctions and reducing the astroglial reactivity in the spinal cord of the treated SOD1G93A mice. Furthermore, NRG1-I overexpression preserved motor function and delayed the onset of clinical disease. In summary, our data indicates that NRG1 plays an important role on MN survival and muscle innervation in ALS, and that viral-mediated overexpression of NRG1 isoforms may be considered as a promising approach for ALS treatment

Targeted deep sequencing of CD34+ cells from peripheral blood can reproduce bone marrow molecular profile in myelodysplastic syndromes

Altres ajuts: José Carreras Leukämie-Stiftung, Award/Grant number: project AR 14/34

Document marc d’educació grupal: programa de prevenció i atenció a la cronicitat

Programa de prevenció i atenció a la cronicitat; Educació grupal; Professionals sanitarisPrograma de prevención y atención a la cronicidad; Educación grupal; Profesionales sanitariosChronicity prevention and care program; Group education; Health professionalsAquest document adreçat a tots els professionals sanitaris és el document marc per a l'educació grupal, model participatiu i adaptat a les necessitats a les necessitats de la comunitat, dins l'àmbit de l'educació per a la salut

Información, prevención e intervención en los factores de riesgo de la presbicia

OBJECTIU: L’ objectiu general que es planteja és analitzar si la utilització de dispositius òptics d’ augment per realitzar tasques en visió propera per temps prolongats pot ser un factor de risc pels usuaris en l’ aparició primerenca de la presbícia i/o signes i símptomes freqüents d’ astenopia ocular . MÉTODE: Es realitza una enquesta d’ hàbits en les tasques visuals a la població general i també a usuaris de dispositius de visió directa. S’ han seleccionat 4 usuaris d’ aquests últims i 4 individus control que estiguin en el marc de criteris d’ inclusió i exclusió i s’ han realitzat les proves d’ acomodació corresponents a AV de prop, amplitud d’ acomodació, flexibilitat i resposta acomodativa. RESULTATS: Els resultats de l'enquesta revelen que són molts els individus que fan tasques de visió propera i mostren simptomatologia ocular com l'astenopia o coïssor entre d'altres. Els resultats obtinguts en els exàmens visuals mostren una estadística no significativa entre grup control i grup experimental CONCLUSIONS: En concordança amb les hipòtesis presentades, l'aparició de símptomes d'astenopia ocular entre usuaris de dispositius observació directa s'evidencia com a resultat del sondeig realitzat. Tanmateix, l'aparició d'una presbícia primerenca no sembla concloent a l'estadística dels exàmens visuals realitzats atesa les limitacions del projecte presents. Es poden dirigir projeccions d'aquest treball com incrementar la mida de la mostra i fer controls de seguiment abans d’ iniciar el treball i per valorar la evolució i així corroborar o refutar la hipòtesi plantejada.OBJETIVO: El objetivo general que se plantea es analizar si la utilización de dispositivos ópticos de aumento para realizar tareas en visión cercana por tiempos prolongados puede ser un factor de riesgo para los usuarios en la aparición temprana de la presbicia y/o signos y síntomas frecuentes de astenopia ocular. MÉTODO: Se realiza una encuesta de hábitos en las tareas visuales a la población general y también a usuarios de dispositivos de visión directa. Se han seleccionado 4 de estos últimos y 4 individuos control y se han realizado las pruebas de acomodación correspondientes a agudeza visual de cerca, amplitud de acomodación, flexibilidad y respuesta acomodativa RESULTADOS: Los resultados de la encuesta revelan que son muchos los individuos que realizan tareas de visión próxima y muestran sintomatología ocular como la astenopia o escozor entre otros. Los resultados obtenidos en los exámenes visuales muestran una estadística no significativa entre grupo control y grupo experimental. CONCLUSIONES: En concordancia a las hipótesis presentadas, la aparición de síntomas de astenopia ocular entre usuarios de dispositivos observación directa se evidencia como resultado de la encuesta realizada. Sin embargo, la aparición de una presbicia temprana no parece ser concluyente a la estadística de los exámenes visuales realizados entre el grupo problema y control dada las limitaciones del trabajo presentes. Se pueden abordar las limitaciones incrementando el tamaño de la muestra y realizando controles visuales de seguimiento antes de iniciar el trabajo y periódicamente para valorar la evolución de los usuarios y poder aceptar o refutar la hipótesis planteadaPURPOSE: The general objective is to analyse whether the use of optical magnification devices to perform near vision tasks for extended periods of time can be a risk factor for users in the early appearance of presbyopia and/or signs and frequent symptoms of ocular asthenopia. METHOD: A survey of habits in visual tasks is carried out in the general population and in users of direct vision devices. 4 users of the latter and 4 control individuals have been selected who are within the framework of inclusion and exclusion criteria and the accommodation tests corresponding to AV near, amplitude of accommodation, flexibility and response have been carried out accommodating RESULTS: The results of the survey reveal that there are many individuals who do close vision tasks and show eye symptoms such as asthenopia or sting among others. The results obtained in the visual examinations show a non-significant statistic between the control group and the experimental group CONCLUSIONS: In accordance with the hypotheses presented, the appearance of symptoms of ocular asthenopia among users of direct observation devices is evidenced because of the survey carried out. However, the appearance of early presbyopia does not seem conclusive in the statistics of the visual examinations performed given the limitations of the present project. Projections of this work can be directed such as increasing the size of the sample and carrying out follow-up checks before starting the work and to assess the evolution and thus corroborate or refute the hypothesized hypothesis

Developmental and tissue-specific involvement of peroxisome proliferator-activated receptor-alpha in the control of mouse uncoupling protein-3 gene expression.

Uncoupling protein-3 (UCP3) is a member of the mitochondrial carrier family expressed preferentially in skeletal muscle and heart. It appears to be involved in metabolic handling of fatty acids in a way that minimizes excessive production of reactive oxygen species. Fatty acids are powerful regulators of UCP3 gene transcription. We have found that the role of peroxisome proliferator-activated receptor-α (PPARα) on the control of UCP3 gene expression depends on the tissue and developmental stage. In adults, UCP3 mRNA expression is unaltered in skeletal muscle from PPARα-null mice both in basal conditions and under the stimulus of starvation. In contrast, UCP3 mRNA is down-regulated in adult heart both in fed and fasted PPARα-null mice. This occurs despite the increased levels of free fatty acids caused by fasting in PPARα-null mice. In neonates, PPARα-null mice show impaired UCP3 mRNA expression in skeletal muscle in response to milk intake, and this is not a result of reduced free fatty acid levels. The murine UCP3 promoter is activated by fatty acids through either PPARα or PPARδ but not by PPARγ or retinoid X receptor alone. PPARδ-dependent activation could be a potential compensatory mechanism to ensure appropriate expression of UCP3 gene in adult skeletal muscle in the absence of PPARα. However, among transcripts from other PPARα and PPARδ target genes, only those acutely induced by milk intake in wild-type neonates were altered in muscle or heart from PPARα-null neonates. Thus, PPARα-dependent regulation is required for appropriate gene regulation of UCP3 as part of the subset of fatty-acid-responsive genes in neonatal muscle and heart

Differential regulation of expression of genes encoding uncoupling proteins 2 and 3 in brown adipose tissue during lactation in mice

Thermogenic activity in brown adipose tissue (BAT) decreases during lactation ; the down-regulation of the gene encoding uncoupling protein 1 (UCP1) is involved in this process. Our studies show that UCP2 mRNA expression does not change during the breeding cycle in mice. In contrast, UCP3 mRNA is down-regulated in lactation but it recovers after weaning, in parallel with UCP1 mRNA. This leads to a decrease in the content of UCP3 in BAT mitochondria during lactation. Lowering the energy-sparing necessities of lactating dams by decreasing litter size or feeding with a high-fat diet prevented the down-regulation of UCP1 mRNA and UCP3 mRNA. In most cases this resulted in a less marked decrease in UCP1 and UCP3 protein in BAT mitochondria owing to lactation. Fasting for 24 h caused a different response in UCP1 and UCP3 mRNA expression : it decreased UCP1 mRNA levels but had no effect on UCP3 mRNA abundance in virgin mice ; it even increased UCP