2,477 research outputs found
Quantum Critical Scaling in a Moderately Doped Antiferromagnet
Using high temperature expansions for the equal time correlator and
static susceptibility for the t-J model, we present evidence for
quantum critical (QC), , behavior at intermediate temperatures in a
broad range of ratio, doping, and temperatures. We find that the
dynamical susceptibility is very close to the universal scaling function
computable for the asymptotic QC regime, and that the dominant energy scale is
temperature. Our results are in excellent agreement with measurements of the
spin-echo decay rate, , in LaCuO, and provide qualitative
understanding of both and nuclear relaxation rates in
doped cuprates.Comment: 11 pages, REVTeX v3.0, PostScript file for 3 figures is attached,
UIUC-P-93-07-068. In this revised version, we calculate the scaling functions
and thus present new and more direct evidence in favor of our original
conclusion
Pan-squamous genomic profiling stratified by anatomic tumor site and viral association
Background: Squamous cell carcinomas (SCC) have diverse anatomic etiologies but may share common genomic biomarkers. We profiled 7,871 unique SCCs across nine anatomic sites to investigate commonality in genomic alterations (GA), tumor mutational burden (TMB), human papillomavirus (HPV) association, and mutational signatures.
Methods: Tissue from over 8,100 unique SCC samples originating from nine anatomic sites (anogenital (anus, cervix, penis, vagina, vulva), esophagus, head and neck, lung, and skin) were sequenced by hybrid capture-based comprehensive genomic profiling to evaluate GA and TMB. About 3% of non-cutaneous SCC samples had UV signatures, indicative of potential primary site misdiagnoses, and were filtered from the analysis. Detection of HPV, including high-risk strains 16, 18, 31, 33, and 45, was implemented through de novo assembly of non-human sequencing reads and BLASTn comparison against all viral nucleotide sequences in the NCBI database.
Results: The proportion of HPV+ patients by anatomic site varied, with the highest being anal (91%) and cervical (83%). The mutational landscape of each cohort was similar, regardless of anatomic origin, but clustered based on HPV status. The largest differences in GA frequency as stratified by HPV- vs. HPV+ were TP53 (87% vs. 12%), CDKN2A (45% vs. 6%), and PIK3CA (22% vs. 33%). The median TMB in cases originating from HPV-associated sites was similar, regardless of HPV status. Higher median TMB was observed in lung and skin cases, which exhibited significant enrichment of mutational signatures indicative of tobacco- and UV-induced DNA damage, respectively.
Conclusions: HPV+ and HPV- SCC populations have distinct genomic profiles and, for the latter, anatomic site is correlated with TMB distribution, secondary to associated carcinogen exposure. As such, biomarkers such as TMB and UV signature can provide unexpected insight into site of origin misdiagnoses and may correlate with benefit from immune checkpoint inhibitors
Spin Dynamics of La_2CuO_4 and the Two-Dimensional Heisenberg Model
The spin-lattice relaxation rate and the spin echo decay rate
for the 2D Heisenberg model are calculated using quantum Monte Carlo
and maximum entropy analytic continuation. The results are compared to recent
experiments on LaCuO, as well as predictions based on the non-linear
-model.Comment: Compressed & uuencoded Postscript file (4 pages with figures
Interstellar neutral helium in the heliosphere from IBEX observations. III. Mach number of the flow, velocity vector, and temperature from the first six years of measurements
We analyzed observations of interstellar neutral helium (ISN~He) obtained
from the Interstellar Boundary Explorer (IBEX) satellite during its first six
years of operation. We used a refined version of the ISN~He simulation model,
presented in the companion paper by Sokol_et al. 2015, and a sophisticated data
correlation and uncertainty system and parameter fitting method, described in
the companion paper by Swaczyna et al 2015. We analyzed the entire data set
together and the yearly subsets, and found the temperature and velocity vector
of ISN~He in front of the heliosphere. As seen in the previous studies, the
allowable parameters are highly correlated and form a four-dimensional tube in
the parameter space. The inflow longitudes obtained from the yearly data
subsets show a spread of ~6 degree, with the other parameters varying
accordingly along the parameter tube, and the minimum chi-square value is
larger than expected. We found, however, that the Mach number of the ISN~He
flow shows very little scatter and is thus very tightly constrained. It is in
excellent agreement with the original analysis of ISN~He observations from IBEX
and recent reanalyses of observations from Ulysses. We identify a possible
inaccuracy in the Warm Breeze parameters as the likely cause of the scatter in
the ISN~He parameters obtained from the yearly subsets, and we suppose that
another component may exist in the signal, or a process that is not accounted
for in the current physical model of ISN~He in front of the heliosphere. From
our analysis, the inflow velocity vector, temperature, and Mach number of the
flow are equal to lambda_ISNHe = 255.8 +/- 0.5 degree, beta_ISNHe = 5.16 +/-
0.10 degree, T_ISNHe = 7440 +/- 260 K, v_ISNHe = 25.8 +/- 0.4$ km/s, and
M_ISNHe = 5.079 +/- 0.028, with uncertainties strongly correlated along the
parameter tube.Comment: Updated reference
The equation of state for two-dimensional hard-sphere gases: Hard-sphere gases as ideal gases with multi-core boundaries
The equation of state for a two-dimensional hard-sphere gas is difficult to
calculate by usual methods. In this paper we develop an approach for
calculating the equation of state of hard-sphere gases, both for two- and
three-dimensional cases. By regarding a hard-sphere gas as an ideal gas
confined in a container with a multi-core (excluded sphere) boundary, we treat
the hard-sphere interaction in an interacting gas as the boundary effect on an
ideal quantum gas; this enables us to treat an interacting gas as an ideal one.
We calculate the equation of state for a three-dimensional hard-sphere gas with
spin , and compare it with the results obtained by other methods. By this
approach the equation of state for a two-dimensional hard-sphere gas can be
calculated directly.Comment: 9 pages, 1 figur
Strontium migration assisted by oxygen vacancies in SrTiO3 from classical and quantum mechanical simulations
First Detection of the White-Dwarf Cooling Sequence of the Galactic Bulge
We present Hubble Space Telescope data of the low-reddening Sagittarius
window in the Galactic bulge. The Sagittarius Window Eclipsing Extrasolar
Planet Search field (3'x3'), together with three more Advanced Camera for
Surveys and eight Wide Field Camera 3 fields, were observed in the F606W and
F814W filters, approximately every two weeks for two years, with the principal
aim of detecting a hidden population of isolated black holes and neutron stars
through astrometric microlensing. Proper motions were measured with an accuracy
of ~0.1 mas/yr (~4 km/s) at F606W~25.5 mag, and better than ~0.5 mas/yr (20
km/s) at F606W~28 mag, in both axes. Proper-motion measurements allowed us to
separate disk and bulge stars and obtain a clean bulge color-magnitude diagram.
We then identified for the first time a white dwarf (WD) cooling sequence in
the Galactic bulge, together with a dozen candidate extreme horizontal branch
stars. The comparison between theory and observations shows that a substantial
fraction of the WDs (30%) are systematically redder than the cooling tracks for
CO-core H-rich and He-rich envelope WDs. This evidence would suggest the
presence of a significant number of low-mass WDs and WD - main sequence
binaries in the bulge. This hypothesis is further supported by the finding of
two dwarf novae in outburst, two short-period (P < 1 d) ellipsoidal variables,
and a few candidate cataclysmic variables in the same field.Comment: 9 pages, 5 figures, accepted for publication on Ap
Embedded-Cluster Calculations in a Numeric Atomic Orbital Density-Functional Theory Framework
We integrate the all-electron electronic structure code FHI-aims into the
general ChemShell package for solid-state embedding (QM/MM) calculations. A
major undertaking in this integration is the implementation of pseudopotential
functionality into FHI-aims to describe cations at the QM/MM boundary through
effective core potentials and therewith prevent spurious overpolarization of
the electronic density. Based on numeric atomic orbital basis sets, FHI-aims
offers particularly efficient access to exact exchange and second order
perturbation theory, rendering the established QM/MM setup an ideal tool for
hybrid and double-hybrid level DFT calculations of solid systems. We illustrate
this capability by calculating the reduction potential of Fe in the
Fe-substituted ZSM-5 zeolitic framework and the reaction energy profile for
(photo-)catalytic water oxidation at TiO2(110).Comment: 12 pages, 4 figure
Landau theory of phase separation in cuprates
I discuss the problem of phase separation in cuprates from the point of view
of the Landau theory of Fermi liquids. I calculate the rate of growth of
unstable regions for the hydrodymanics and collisionless limit and, in presence
of long range Coulomb interactions, the size of these regions. These are
analytic results valid for any strength of the Landau parameters.Comment: RevteX, preprint ITP (1994
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