Frontal activity measured by near-infrared spectroscopy in patients taking different atypical antipsychotic drugs: A cross-sectional study

博士（医学）福島県立医科大

自然発生黒色腫担癌豚の選択的熱中性子捕捉療法 : 線量分布と局所反応の検討

前臨床実験として自然発生黒色腫担癌豚に10B-BPA(10B-Para-boronophenylalanine)を用いた選択的熱中性子捕捉療法を施行し,その時の局所,全身の中性子およびγ線の線量分布を調べたので局所反応とともに報告する.熱中性子源として武蔵工業大学原子炉研究所の原子炉を用いた.10B-BPA 15.8g(200mg/kg)を経静脈的に投与し,100kw,210分間の熱中性子照射を行った.腫瘍部以外を遮蔽するために,bismuth面より順にLiFシート,LiFタイル,鉛ブロックを配置した.上記collimation systemにより腫瘍周辺組織の熱中性子線量を腫瘍部の約1/100に減弱させることができ,また全身被曝線量軽減の意味からも効果を認めた.また,局所反応においても,ビラン,潰瘍等を伴わず治療傾向を示した.We carried out pre-clinical experiment for treatment of spontaneously occurring melanoma using 10B-Para-boronophenylalanine (10B-BPA) and also measured actual dose distribution of neutron and γ-ray irradiation on melanoma itself, surrounding normal tissue and distant body surfaces. As the source of the thermal neutron beam, we used Musashi Institute of Technology Reactor for Medical Purposes. An hour prior to thermal neutron irradiation of 100kw for 210 minutes, 15.8g of 10B-BPA (200mg/kg) was administered to the pig then the pig was undertaken general anesthesia which was remotely maintained and set in irradiation in front of the bismuth surface of the reactor. LiF tiles, LiF sheets and lead blocks were arranged as the collimator for shielding the pig skin but for the melanoma lesion. The neutron fluence to tumor surrounding normal skin was about one hundredth of that to melanoma and this collimation system was so effective that further decrease in neutron fluence and γ-ray to distant body surface were attained. As the result of this experiment, the pig melanoma showed complete disappearance and the lesion was covered by normal skin without erosive and ulcerative changes

Direct interaction between metastasis-associated protein 1 and endophilin 3

AbstractThe yeast two-hybrid system was used to search for partners of mouse metastasis-associated protein 1 (Mta1). Screening of a cDNA library prepared from mouse embryo yielded positive clones coding for endophilin 3. The site of interaction was suggested to be the SH-3-binding domain of Mta1 and SH-3 domain of endophilin 3. This interaction was confirmed by GST pull-down assay in vitro and immunoprecipitation in vivo. The Mta1 and endophilin 3 transcripts were highly expressed in testis and brain. But, Mta1 localized mainly in nucleus and to a lesser extent in cytoplasm while endophilin 3 localized mainly in cytoplasm. If Mta1 functions in cytoplasm, it might be involved in the regulation of endocytosis mediated by endophilin 3

Machine tool calibration: Measurement, modeling, and compensation of machine tool errors

International audienceAdvanced technologies for the calibration of machine tool are presented. Geometric, kinematic, thermally-induced and load-induced errors are classified into errors within one-axis as intra-axis errors, errors between axes as inter-axis errors, and as volumetric errors. As the major technological elements of machine tool calibration, the measurement methods, mathematical models and compensation approaches of the machine tool errors are addressed. The criteria for selecting a combination of the technological elements for machine tool calibration from the point of view of accuracy, complexity, and cost are provided. Recent applications of artificial intelligence and machine learning in machine tool calibration are introduced. Remarks are also made on future trends in machine tool calibration

Evaluation of Brain Activity Using Near-infrared Spectroscopy in Inflammatory Bowel Disease Patients

Abstract Depression is implicated as a risk factor for the recurrence of inflammatory bowel disease (IBD). Near-infrared spectroscopy (NIRS) and brain-derived neurotrophic factor (BDNF) are useful tools for evaluation of brain activity and a depressive state, respectively. The aim of this study was to clarify the association between brain activity or depressive symptoms and IBD using NIRS and BDNF. This study included 36 ulcerative colitis (UC) patients, 32 Crohn’s disease (CD) patients, and 17 healthy controls (HC). Center for Epidemiologic Studies Depression Scale (CES-D) scores were determined, NIRS was performed, and serum BDNF levels were measured in all subjects. NIRS showed that the mean oxygenated hemoglobin concentration was significantly lower in the frontal lobe in the UC group than in the HC group (HC 167 ± 106 vs. UC 83.1 ± 85.3, p < 0.05). No significant difference was seen between the HC and CD groups. There were also no significant differences in CED-D scores and BDNF levels among the groups. Changes in the NIRS values of the UC group may indicate decreased brain activity and a fundamental difference between UC and CD, which are often lumped together as two types of IBD