54 research outputs found
Long-Term Glycaemic Durability of Early Combination Therapy Strategy versus Metformin Monotherapy in Korean Patients with Newly Diagnosed Type 2 Diabetes Mellitus
We assessed the glycaemic durability with early combination (EC; vildagliptin+metformin [MET], n=22) versus MET monotherapy (n=17), among newly-diagnosed type 2 diabetes mellitus (T2DM) enrolled (between 2012 and 2014) in the VERIFY study from Korea (n=39). Primary endpoint was time to initial treatment failure (TF) (glycosylated hemoglobin [HbA1c]>= 7.0% at two consecutive scheduled visits after randomization [end of period 1]). Time to second TF was assessed when both groups were receiving and failing on the combination (end of period 2). With EC the risk of initial TF significantly reduced by 78% compared to MET (n=3 [15%] vs. n=10 [58.7%], P=0.0228). No secondary TF occurred in EC group versus five patients (29.4%) in MET. Patients receiving EC treatment achieved consistently lower HbA1c levels. Both treatment approaches were well tolerated with no hypoglycaemic events. In Korean patients with newly diagnosed T2DM, EC treatment significantly and consistently improved the long-term glycaemic durability as compared with MET.Peer reviewe
Efficacy and Safety of Enavogliflozin versus Dapagliflozin as Add-on to Metformin in Patients with Type 2 Diabetes Mellitus: A 24-Week, Double-Blind, Randomized Trial
Background Enavogliflozin is a novel sodium-glucose cotransporter-2 inhibitor currently under clinical development. This study evaluated the efficacy and safety of enavogliflozin as an add-on to metformin in Korean patients with type 2 diabetes mellitus (T2DM) against dapagliflozin. Methods In this multicenter, double-blind, randomized, phase 3 study, 200 patients were randomized to receive enavogliflozin 0.3 mg/day (n=101) or dapagliflozin 10 mg/day (n=99) in addition to ongoing metformin therapy for 24 weeks. The primary objective of the study was to prove the non-inferiority of enavogliflozin to dapagliflozin in glycosylated hemoglobin (HbA1c) change at week 24 (non-inferiority margin of 0.35%) (Clinical trial registration number: NCT04634500). Results Adjusted mean change of HbA1c at week 24 was โ0.80% with enavogliflozin and โ0.75% with dapagliflozin (difference, โ0.04%; 95% confidence interval, โ0.21% to 0.12%). Percentages of patients achieving HbA1c <7.0% were 61% and 62%, respectively. Adjusted mean change of fasting plasma glucose at week 24 was โ32.53 and โ29.14 mg/dL. An increase in urine glucose-creatinine ratio (60.48 vs. 44.94, P<0.0001) and decrease in homeostasis model assessment of insulin resistance (โ1.85 vs. โ1.31, P=0.0041) were significantly greater with enavogliflozin than dapagliflozin at week 24. Beneficial effects of enavogliflozin on body weight (โ3.77 kg vs. โ3.58 kg) and blood pressure (systolic/diastolic, โ5.93/โ5.41 mm Hg vs. โ6.57/โ4.26 mm Hg) were comparable with those of dapagliflozin, and both drugs were safe and well-tolerated. Conclusion Enavogliflozin added to metformin significantly improved glycemic control in patients with T2DM and was non-inferior to dapagliflozin 10 mg, suggesting enavogliflozin as a viable treatment option for patients with inadequate glycemic control on metformin alone
Clinical Features of Probable Cluster Headache: A Prospective, Cross-Sectional Multicenter Study
Background: Epidemiological data of probable cluster headaches (CH) are scarce in the relevant literature. Here, we sought to assess the prevalence and clinical characteristics of probable CH in comparison with definite CH.Methods: Data used in this study were obtained from the Korean Cluster Headache Registry (KCHR), a prospective, cross-sectional, multicenter headache registry that collected data from consecutive patients diagnosed with CH.Results: In total, 159 patients were enrolled in this study; 20 (12.6%) were diagnosed with probable CH. The most common unfulfilled criterion in patients with probable CH was the duration of attack, which was found in 40% of patients with probable CH. Among clinical characteristics, the number of autonomic symptoms tended to be lower in probable CH than in definite CH (1.7 ยฑ 1.2 vs. 2.4 ยฑ 1.5, p = 0.051) and conjunctival injection and lacrimation showed an increased odds ratio (OR) [OR = 3.03; 95% confidence interval (CI): 1.03โ8.33] in definite CH. The groups did not differ with regard to baseline demographic characteristics, disability, impact on life, or treatment response.Conclusions: Probable CH is relatively common among CH disorders, with a clinical impact similar to that of definite CH
Survey of the public's knowledge and opinions;the therapeutic effects of current orally administered drugs for periodontal diseases
๋ชฉ์ : ์ด๋ฒ ์ฐ๊ตฌ์์๋ ์ผ๋ฐ์ธ์ ์น์ฃผ์งํ ์น๋ฃ์ ์ ๋ํ ์ธ์๋๋ฅผ ์ค๋ฌธ์ ํตํ์ฌ ์์๋ณด์๊ณ ํ์ฌ ๊ตญ๋ด์์ ์ํ์ค์ธ ์น์ฃผ์งํ, ์น๋ฃ์ ๋ฅผ ์์ฝํ ๊ฒ์ ์ฌ์ดํธ๋ฅผ ์ด์ฉํ์ฌ ์กฐ์ฌํ์๋ค. ์กฐ์ฌํ ์น๋ฃ์ ์ ํจ๊ณผ๋ฅผ ํด๋น ์ฝํ์ ์ฑ๋ถ๊ณผ ๊ด๋ จ๋ ๋ฌธํ์ ๊ณ ์ฐฐํจ์ผ๋ก์จ ์์๋ณด์๋ค. ์ฌ๋ฃ ๋ฐ ๋ฐฉ๋ฒ : ์ผ๋ฐ์ธ์ ์น์ฃผ์งํ ์น๋ฃ์ ์ ๋ํ ์ธ์ง๋๋ฅผ ์กฐ์ฌํ๊ธฐ ์ํ์ฌ ์ด ๊ฐ์ ๋ฌธํญ์ผ๋ก ๊ตฌ์ฑ๋ ์ค๋ฌธ์ ์ค์ํ์๋ค. ์ค๋ฌธ์ ํ๋ฆผ๋ํ๊ต ์ฑ์ฌ๋ณ์ ์ฐ์
์ํ๊ณผ์ ์ ๊ธฐ ๊ฑด๊ฐ๊ฒ์ง์ ์ํ์ฌ ๋ด์ํ ์ฌ๋๋ค์ ๋์์ผ๋ก ํ์๋ค. ๋ณด๊ฑด๋ณต์ง๋ถ์ ๋ฑ๋ก๋ ์น์ฃผ์งํ ์น๋ฃ์ ๋ฅผ ์กฐ์ฌํ๊ธฐ ์ํ์ฌ ํด์ค ์จ๋ผ์ธ ํํ์ด์ง๋ฅผ ์ด์ฉํ์๋ค. ์์ฝํ ์ข
ํฉ ๊ฒ์ ํ์ด์ง์์ '์ถ๊ฐ์กฐ๊ฑด ์
๋ ฅํ๊ธฐ'์ '๋ณต์ง๋ถ ๋ถ๋ฅ'๋์ '231. ์น๊ณผ-๊ตฌ๊ฐ์ฉ์ฝ'์ ์กฐ๊ฑด์ ์ฃผ์ด ๊ฒ์ํ์๋ค. ๊ฒ์ ๊ฒฐ๊ณผ๋ก๋ถํฐ ๊ฒฝ๊ตฌ ์น์ฃผ์งํ ์น๋ฃ์ ๋ฅผ ๊ตฌ๋ณํ์ฌ ์ ๋ฆฌํ์๋ค. ์น์ฃผ์งํ ์น๋ฃ์ ์ ๊ด๋ จ๋ ๋ฌธํ์ ์กฐ์ฌํ๊ธฐ ์ํ์ฌ ๋ฏธ๊ตญ ๊ตญ๋ฆฝ๋์๊ด์ ๊ฒ์ ์๋น์ค์ธ Pubmed ํํ์ด์ง๋ฅผ ์ด์ฉํ์๋ค. ๊ฒ์์ด๋ ๊ฐ ์ง๋ฃ์ ์ ์ฑ๋ถ๋ช
๊ณผ ์น์์ผ, ์น์ฃผ์ผ, ์น์ฃผ์งํ์ ์กฐํฉ์ด๋ฅผ ์ฌ์ฉํ์๋ค. ๊ฒฐ๊ณผ : ์ค๋ฌธ์ ์ฐธ์ฌํ ์ฌ๋์ 100๋ช
์ด์๋ค. ์ด ์ค 85%๋ ์น์ฃผ์งํ์ด๋ผ๋ ๋ง์ ๋ค์ด๋ณธ ์ ์ด ์์์ผ๋ฉฐ 72%๋ ์์ ์ ์น์ฃผ๊ฑด๊ฐ์ํ๊ฐ ์ข์ง ์๋ค๊ณ ์๊ฐํ์๋ค. 14%๋ ์น์ฃผ์งํ ์น๋ฃ์ ๋ฅผ ๋ณต์ฉํ ๊ฒฝํ์ด ์์๋ค. 61%๋ ์น์ฃผ์งํ ์น๋ฃ์ ์ ๊ดํ ์ ๋ณด๋ฅผ ๊ด๊ณ ๋ก๋ถํฐ ํ๋ํ์๋ค. ํฅํ ์น์ฃผ์งํ ์น๋ฃ์ ์ ์ ํ๊ณผ ๊ด๋ จํ์ฌ 35%๋ ์น๊ณผ์์ฌ์๊ฒ, 24%๋ ์์ฌ์๊ฒ ๊ทธ๋ฆฌ๊ณ 20%๋ ์ฝ์ฌ์๊ฒ ๋ฌธ์ํ๊ฒ ๋ค๊ณ ๋๋ตํ์๋ค. ์น์ฃผ์งํ ์น๋ฃ์ ๋ 70๊ฐ์๋ค. ์ด ์ค 38๊ฐ๋ ์์ค์ฝ๋ฅด๋น์ฐ ์ ์ , 25๊ฐ๋ ์ฅ์์ ๋ถ๊ฒํ ์ถ์ถ๋ฌผ ์ ์ , 5๊ฐ๋ ์ ์ฉ๋ ๋
์์ธ์ดํด๋ฆฐ ์ ์ ์๊ณ ์๋ณด์นด๋-์ฝฉ ๋ถ๊ฒํ๋ฌผ๊ณผ ๋์์ํ์ ์ ์ ๊ฐ ๊ฐ๊ฐ ํ ๊ฐ์๋ค. ๊ฒฐ๋ก : ์น์ฃผ์งํ ์น๋ฃ์ ์ ๋ํ ์ผ๋ฐ์ธ์ ์ธ์ง๋๋ ๋น๊ต์ ๋ฎ์์ผ๋ฉฐ ์ ๋ณด๋ฅผ ํ๋ํ๋ ์ฃผ์ ๊ฒฝ๋ก๋ ๊ด๊ณ ์๋ค. ์ผ๋ฐ์ธ๋ค์ด ์น์ฃผ์งํ ์น๋ฃ์ ๋ฅผ ์ ํํ๋ ๋ฐ ์น๊ณผ์์ฌ๋ ํฐ ์ญํ ์ ํ์ง ๋ชปํ์๋ค. ์ํ์ค์ธ ์น์ฃผ์งํ ์น๋ฃ์ ๋ 70๊ฐ์๋ค. ์น๋ฃ์ ๋ ๋ค์ฏ ๊ฐ์ ๊ตฐ์ผ๋ก ๋ถ๋ฅํ ์ ์์์ผ๋ฉฐ, ์์ค์ฝ๋ฅด๋น์ฐ ์ ์ , ์ฅ์์ ๋ถ๊ฒํ ์ถ์ถ๋ฌผ ๋ฐ ์ ์ฉ๋ ๋
์์ธ์ดํด๋ฆฐ์ด ๋๋ถ๋ถ์ด์๊ณ ์๋ณด์นด๋-์ฝฉ ๋ถ๊ฒํ๋ฌผ๊ณผ ๋์์ํ์ ์ ์ ๋ ๊ฐ๊ฐ ํ ๊ฐ์๋ค. ์ฅ์์ ๋ถ๊ฒํ ์ถ์ถ๋ฌผ๊ณผ ์ ์ฉ๋ ๋
์์ธ์ดํด๋ฆฐ์ ์์ ์ฐ๊ตฌ์ ์ํด ๊ทธ ํจ๊ณผ๊ฐ ์
์ฆ๋์์ผ๋ ์์ค์ฝ๋ฅด๋น์ฐ ์ ์ ๋ ์์ ์ฐ๊ตฌ๊ฐ ์์์ผ๋ฉฐ ๋ฐ๋ผ์ ์ด์์ ์ธ ์ ์ ๋ผ๊ณ ํ ์ ์๋ค. ๊ธฐ์กด์ ๋ฌธํ์ ๊ธฐ์ดํ์ฌ ๋ณผ ๋ ์ฅ์์ ๋ถ๊ฒํ ์ถ์ถ๋ฌผ๊ณผ ์ ์ฉ๋ ๋
์์ธ์ดํด๋ฆฐ๋ง์ด ์ ํต์ ์ธ ์น์ฃผ์งํ ์น๋ฃ๋ฒ(SRP)๊ณผ ๋ณํํ์ฌ ์น๋ฃ์ ๋ก ์ฌ์ฉ๋ ์ ์๋ค
์ํ์ค์ธ ๊ฒฝ๊ตฌ ์น์ฃผ์งํ์น๋ฃ์ ์ ํจ๊ณผ์ ๋ํ ์ผ๋ฐ์ธ์ ์ธ์๋ ์กฐ์ฌ
๋ชฉ์ : ์ด๋ฒ ์ฐ๊ตฌ์์๋ ์ผ๋ฐ์ธ์ ์น์ฃผ์งํ ์น๋ฃ์ ์ ๋ํ ์ธ์๋๋ฅผ ์ค๋ฌธ์ ํตํ์ฌ ์์๋ณด์๊ณ ํ์ฌ ๊ตญ๋ด์์ ์ํ์ค์ธ ์น์ฃผ์งํ, ์น๋ฃ์ ๋ฅผ ์์ฝํ ๊ฒ์ ์ฌ์ดํธ๋ฅผ ์ด์ฉํ์ฌ ์กฐ์ฌํ์๋ค. ์กฐ์ฌํ ์น๋ฃ์ ์ ํจ๊ณผ๋ฅผ ํด๋น ์ฝํ์ ์ฑ๋ถ๊ณผ ๊ด๋ จ๋ ๋ฌธํ์ ๊ณ ์ฐฐํจ์ผ๋ก์จ ์์๋ณด์๋ค. ์ฌ๋ฃ ๋ฐ ๋ฐฉ๋ฒ : ์ผ๋ฐ์ธ์ ์น์ฃผ์งํ ์น๋ฃ์ ์ ๋ํ ์ธ์ง๋๋ฅผ ์กฐ์ฌํ๊ธฐ ์ํ์ฌ ์ด ๊ฐ์ ๋ฌธํญ์ผ๋ก ๊ตฌ์ฑ๋ ์ค๋ฌธ์ ์ค์ํ์๋ค. ์ค๋ฌธ์ ํ๋ฆผ๋ํ๊ต ์ฑ์ฌ๋ณ์ ์ฐ์
์ํ๊ณผ์ ์ ๊ธฐ ๊ฑด๊ฐ๊ฒ์ง์ ์ํ์ฌ ๋ด์ํ ์ฌ๋๋ค์ ๋์์ผ๋ก ํ์๋ค. ๋ณด๊ฑด๋ณต์ง๋ถ์ ๋ฑ๋ก๋ ์น์ฃผ์งํ ์น๋ฃ์ ๋ฅผ ์กฐ์ฌํ๊ธฐ ์ํ์ฌ ํด์ค ์จ๋ผ์ธ ํํ์ด์ง๋ฅผ ์ด์ฉํ์๋ค. ์์ฝํ ์ข
ํฉ ๊ฒ์ ํ์ด์ง์์ '์ถ๊ฐ์กฐ๊ฑด ์
๋ ฅํ๊ธฐ'์ '๋ณต์ง๋ถ ๋ถ๋ฅ'๋์ '231. ์น๊ณผ-๊ตฌ๊ฐ์ฉ์ฝ'์ ์กฐ๊ฑด์ ์ฃผ์ด ๊ฒ์ํ์๋ค. ๊ฒ์ ๊ฒฐ๊ณผ๋ก๋ถํฐ ๊ฒฝ๊ตฌ ์น์ฃผ์งํ ์น๋ฃ์ ๋ฅผ ๊ตฌ๋ณํ์ฌ ์ ๋ฆฌํ์๋ค. ์น์ฃผ์งํ ์น๋ฃ์ ์ ๊ด๋ จ๋ ๋ฌธํ์ ์กฐ์ฌํ๊ธฐ ์ํ์ฌ ๋ฏธ๊ตญ ๊ตญ๋ฆฝ๋์๊ด์ ๊ฒ์ ์๋น์ค์ธ Pubmed ํํ์ด์ง๋ฅผ ์ด์ฉํ์๋ค. ๊ฒ์์ด๋ ๊ฐ ์ง๋ฃ์ ์ ์ฑ๋ถ๋ช
๊ณผ ์น์์ผ, ์น์ฃผ์ผ, ์น์ฃผ์งํ์ ์กฐํฉ์ด๋ฅผ ์ฌ์ฉํ์๋ค. ๊ฒฐ๊ณผ : ์ค๋ฌธ์ ์ฐธ์ฌํ ์ฌ๋์ 100๋ช
์ด์๋ค. ์ด ์ค 85%๋ ์น์ฃผ์งํ์ด๋ผ๋ ๋ง์ ๋ค์ด๋ณธ ์ ์ด ์์์ผ๋ฉฐ 72%๋ ์์ ์ ์น์ฃผ๊ฑด๊ฐ์ํ๊ฐ ์ข์ง ์๋ค๊ณ ์๊ฐํ์๋ค. 14%๋ ์น์ฃผ์งํ ์น๋ฃ์ ๋ฅผ ๋ณต์ฉํ ๊ฒฝํ์ด ์์๋ค. 61%๋ ์น์ฃผ์งํ ์น๋ฃ์ ์ ๊ดํ ์ ๋ณด๋ฅผ ๊ด๊ณ ๋ก๋ถํฐ ํ๋ํ์๋ค. ํฅํ ์น์ฃผ์งํ ์น๋ฃ์ ์ ์ ํ๊ณผ ๊ด๋ จํ์ฌ 35%๋ ์น๊ณผ์์ฌ์๊ฒ, 24%๋ ์์ฌ์๊ฒ ๊ทธ๋ฆฌ๊ณ 20%๋ ์ฝ์ฌ์๊ฒ ๋ฌธ์ํ๊ฒ ๋ค๊ณ ๋๋ตํ์๋ค. ์น์ฃผ์งํ ์น๋ฃ์ ๋ 70๊ฐ์๋ค. ์ด ์ค 38๊ฐ๋ ์์ค์ฝ๋ฅด๋น์ฐ ์ ์ , 25๊ฐ๋ ์ฅ์์ ๋ถ๊ฒํ ์ถ์ถ๋ฌผ ์ ์ , 5๊ฐ๋ ์ ์ฉ๋ ๋
์์ธ์ดํด๋ฆฐ ์ ์ ์๊ณ ์๋ณด์นด๋-์ฝฉ ๋ถ๊ฒํ๋ฌผ๊ณผ ๋์์ํ์ ์ ์ ๊ฐ ๊ฐ๊ฐ ํ ๊ฐ์๋ค. ๊ฒฐ๋ก : ์น์ฃผ์งํ ์น๋ฃ์ ์ ๋ํ ์ผ๋ฐ์ธ์ ์ธ์ง๋๋ ๋น๊ต์ ๋ฎ์์ผ๋ฉฐ ์ ๋ณด๋ฅผ ํ๋ํ๋ ์ฃผ์ ๊ฒฝ๋ก๋ ๊ด๊ณ ์๋ค. ์ผ๋ฐ์ธ๋ค์ด ์น์ฃผ์งํ ์น๋ฃ์ ๋ฅผ ์ ํํ๋ ๋ฐ ์น๊ณผ์์ฌ๋ ํฐ ์ญํ ์ ํ์ง ๋ชปํ์๋ค. ์ํ์ค์ธ ์น์ฃผ์งํ ์น๋ฃ์ ๋ 70๊ฐ์๋ค. ์น๋ฃ์ ๋ ๋ค์ฏ ๊ฐ์ ๊ตฐ์ผ๋ก ๋ถ๋ฅํ ์ ์์์ผ๋ฉฐ, ์์ค์ฝ๋ฅด๋น์ฐ ์ ์ , ์ฅ์์ ๋ถ๊ฒํ ์ถ์ถ๋ฌผ ๋ฐ ์ ์ฉ๋ ๋
์์ธ์ดํด๋ฆฐ์ด ๋๋ถ๋ถ์ด์๊ณ ์๋ณด์นด๋-์ฝฉ ๋ถ๊ฒํ๋ฌผ๊ณผ ๋์์ํ์ ์ ์ ๋ ๊ฐ๊ฐ ํ ๊ฐ์๋ค. ์ฅ์์ ๋ถ๊ฒํ ์ถ์ถ๋ฌผ๊ณผ ์ ์ฉ๋ ๋
์์ธ์ดํด๋ฆฐ์ ์์ ์ฐ๊ตฌ์ ์ํด ๊ทธ ํจ๊ณผ๊ฐ ์
์ฆ๋์์ผ๋ ์์ค์ฝ๋ฅด๋น์ฐ ์ ์ ๋ ์์ ์ฐ๊ตฌ๊ฐ ์์์ผ๋ฉฐ ๋ฐ๋ผ์ ์ด์์ ์ธ ์ ์ ๋ผ๊ณ ํ ์ ์๋ค. ๊ธฐ์กด์ ๋ฌธํ์ ๊ธฐ์ดํ์ฌ ๋ณผ ๋ ์ฅ์์ ๋ถ๊ฒํ ์ถ์ถ๋ฌผ๊ณผ ์ ์ฉ๋ ๋
์์ธ์ดํด๋ฆฐ๋ง์ด ์ ํต์ ์ธ ์น์ฃผ์งํ ์น๋ฃ๋ฒ(SRP)๊ณผ ๋ณํํ์ฌ ์น๋ฃ์ ๋ก ์ฌ์ฉ๋ ์ ์๋ค
Does Wet-Cupping (Blood-Letting Cupping) Cause Iron Deficiency Anemia? Comments About โA Prospective Evaluation of Adult Men with Iron-deficiency Anemia in Koreaโ Published in Internal Medicine
Associations of Elderly Onset Headache With Occurrence of Poor Functional Outcome, Cardiovascular Disease, and Cognitive Dysfunction During Long-term Follow-up
Background: Although the frequency and intensity of headaches decrease in older adults, headaches in this population are still an important neurological disorder. The purpose of this study was to investigate the associations of headache characteristics in older adults with the development of cardiovascular disease and cognitive dysfunction. Methods: We prospectively enrolled 125 older (โฅ 65 years old) patients with headache who were making their first visit to outpatient clinics and who had no prior history of cognitive dysfunction from 11 hospitals in Korea between August 2014 and February 2015. We investigated the occurrence of newly developed/or recurrent headache, cardiovascular disease, cognitive dysfunction, and poor functional outcomes. Results: The mean age of all included patients was 72.6 years, 68.8% were women, and 43 (34.4%) had newly developed/or recurrent headache during follow-up. During a median follow-up of 31 months (interquartile range, 28โ34 months), 21 participants (16.8%) experienced cardiovascular disease, and 26 (20.8%) developed cognitive dysfunction. Upon multivariate analysis and after adjusting for sex, age, and other factors, presence of newly developed/or recurrent headache was found to be associated with cardiovascular disease (hazard ratio [HR], 4.03; 95% confidence interval [CI], 1.28โ12.61; p=0.017) and frequency of headache for the recent 3 months was related with cognitive dysfunction (HR, 1.05; 95% CI, 1.00โ1.09; p=0.017) and poor functional outcomes (HR, 1.06; 95% CI, 1.01โ1.11; p=0.011). Conclusion: Our study demonstrated that there is an increased risk of cardiovascular disease, cognitive dysfunction, and poor functional outcomes in older patients with frequent, newly developed, or recurrent headache
Sex-Related Outcomes of Successful Drug-Coated Balloon Treatment in De Novo Coronary Artery Disease
Purpose: Although drug-coated balloon (DCB) treatment is known to be effective for de novo lesions, the influence of sex on angiographic and clinical outcomes remains unknown. This study aimed to investigate the angiographic and clinical impact of DCB treatment in patients with de novo coronary lesions according to sex.
Materials and Methods: A total of 227 patients successfully treated with DCB were retrospectively enrolled and divided into two groups according to sex. The primary endpoint was late lumen loss (LLL) at 6-month angiography, and the secondary endpoint was target vessel failure (TVF), which included cardiac death, target vessel myocardial infarction, target lesion revascularization, and target vessel thrombosis.
Results: The study enrolled 60 women (26.4%) and 167 men (73.6%). Compared to men, women had a smaller vessel size, larger DCB to reference vessel ratio, and more dissections after DCB treatment (55.0% vs. 37.1%, p=0.016). Women also had a significandy higher LLL compared to men (0.12 +/- 0.26 mm vs. 0.02 +/- 0.22 mm, p=0.012) at the 6-month follow-up angiography. During a median follow-up of 3.4 years (range 12.7-28.9 months), TVF was similar (women 6.7% vs. men 7.8%, p=0.944). In multivariable analysis, women were independently associated with a higher LLL.
Conclusion: LLL was higher in women, but there was no difference in TVF between women and men. Based on multivariable analysis, the women sex was an independent predictor of higher LLL (Impact of Drug-coated Balloon Treatment in de Novo Coronary Lesion; NCT04619277)
Identification of cerebral perfusion using arterial spin labeling in patients with seizures in acute settings
<div><p>This study aimed to explore the utility of arterial spin labeling perfusion-weighted imaging (ASL-PWI) in patients with suspected seizures in acute settings. A total of 164 patients who underwent ASL-PWI for suspected seizures in acute settings (with final diagnoses of seizure [n = 129], poststroke seizure [n = 18], and seizure mimickers [n = 17]), were included in this retrospective study. Perfusion abnormality was analyzed for: (1) pattern, (2) multifocality, and (3) atypical distribution against vascular territories. Perfusion abnormality was detected in 39% (50/129) of the seizure patients, most (94%, 47/50) being the hyperperfusion pattern. Of the patients with perfusion abnormality, multifocality or hemispheric involvement and atypical distribution against vascular territory were revealed in 46% (23/50) and 98% (49/50), respectively. In addition, seizures showed characteristic features including hyperperfusion (with or without non-territorial distribution) on ASL-PWI, thus differentiating them from poststroke seizures or seizure mimickers. In patients in whom seizure focus could be localized on both EEG and ASL-PWI, the concordance rate was 77%. The present study demonstrates that ASL-PWI can provide information regarding cerebral perfusion status in patients with seizures in acute settings and has the potential to be used as a non-invasive imaging tool to identify the cerebral perfusion in patients with seizures.</p></div
- โฆ