P15: Vaccine Hesitancy or Acceptance in High School Students

Teenage vaccine hesitancy or acceptance in the context of COVID-19, related to public health

Investigating the Health of a Rice Field Ecosystem Using Thermodynamic Extremal Principles

This study investigates the dynamic behaviour of a rice field ecosystem and aims to define its integral features using the stability concept of an ecological goal function. This function is based on the extremal principles of thermodynamics, which assume that certain energetic processes of ecosystems—such as the rate of exergy destruction—are directed by the self-organizing informatics of the systems towards maxima or minima.  In our study, we exploit the availability of substantially long time-series data relating to a rice field ecosystem to gain an evocative understanding of its growth trajectory in light of the thermodynamic principles. We accomplished this by constructing a model based on the STELLA 9.0 software and calculating the extremal values of growth rates (storage) and those of exergy destruction and entropy creation. The results showed that the values of both maximum dissipation and maximum exergy progressed apace with that of maximum storage till the maturation of rice and became stable thereafter, whereas maximum residence time and maximum specific dissipation values initially decreased before their asymptotic rise. A similar pattern was also observed for the maximum specific exergy. However, the maximum power dissipation curve followed a highly fluctuated course before becoming stable on the maturation of rice

Production of bioactive compounds with bactericidal and antioxidant potential by endophytic fungus Alternaria alternata AE1 isolated from Azadirachta indica A. Juss.

For combating multidrug-resistant microorganisms, exploration of natural compounds from plant endophytes increases the chance of finding novel compounds. An efficient bioactive metabolites producing endophytic fungal strain AE1 was isolated from leaves of Azadirachta indica A. Juss. The metabolites were found to be thermostable, non-proteinacious and produced prominent zones of inhibition against numbers of Gram positive and Gram negative bacteria. Based on 28S rDNA (D1/D2) sequence homology the isolate AE1 was identified as Alternaria alternata. Malt extract broth was found effective for the maximum production of bioactive metabolites by the isolate and was subjected for solvent extraction. The Ethyl acetate (EA) fraction of AE1 showed MIC values of 300-400 μg/ml against Gram positive and Gram negative bacteria tested. The cidal mode of action of EA fraction was detected by treating bacterial cultures at mid log phase. Scanning electron microscopic study supported morphological disintegration of bacterial cells. Release of nucleic acid, protein and potassium ions (K+) also suggested lysis of bacterial cells or leakage of cell membrane upon treatment. In addition, reduction of the activity of EMP pathway, TCA cycle and gluconeogenic enzymes in all bacteria suggested the interference of antibacterial principles with central carbohydrate metabolic pathways. Thin layer chromatographic separation followed by GC-MS analysis of EA fraction suggested numbers of antimicrobial compound production by AE1. In addition, DPPH free radical as well as superoxide radical scavenging assay also suggested strong antioxidant potential of AE1 with an IC50 value of 38.0±1.7 μg/ml and 11.38±1.2 μg/ml respectively. On the basis of above facts it can be concluded that the strain AE1 will be a good source of bioactive compounds having medicinal importance

Ocular manifestations in Kindler syndrome

We aimed describe the chronic ocular sequelae of Kindler syndrome. All cases of Kindler syndrome with ocular involvement that presented to a tertiary eye care center were included. Three cases of Kindler syndrome with ocular changes were reviewed. Case 1 (10 years, female) had recurrent epithelial breakdown with severe dry eye and corneal opacity secondary to keratitis. Case 2 (28 years, male) had symblepharon , ocular surface keratinization , and severe dry eye. Case 3 (16 years , female ) had partial limbal stem cell deficiency with dry eye. All cases were treated with topical lubricants, short course of low-potency steroids and immuno-modulators. Attention must be paid to the eye in addition to the oro-an-genital mucosa to avoid longterm ocular sequelae

Characterization of retinal hemorrhages delimited by the internal limiting membrane

Clinically, hemorrhages at the vitreoretinal interface have been termed as 'pre-retinal' in location. However, there is a careful distinction to be made between sub-hyaloid and sub-internal limiting membrane (ILM) planes of blood collection. In the past half-century, a body of literature has accrued on sub-internal limiting membrane hemorrhage. We characterize the etiopathological, clinical, anatomical, and imaging characteristics of this entity (often misconstrued as sub-hyaloid hemorrhage). Management decisions are briefly described, and a unifying term of sub-internal limiting membrane macular hemorrhage is proposed to aid in further research

Investigating the Health of a Rice Field Ecosystem Using Thermodynamic Extremal Principles

This study investigates the dynamic behaviour of a rice field ecosystem and aims to define its integral features using the stability concept of an ecological goal function. This function is based on the extremal principles of thermodynamics, which assume that certain energetic processes of ecosystems—such as the rate of exergy destruction—are directed by the self-organizing informatics of the systems towards maxima or minima. In our study, we exploit the availability of substantially long time-series data relating to a rice field ecosystem to gain an evocative understanding of its growth trajectory in light of the thermodynamic principles. We accomplished this by constructing a model based on the STELLA 9.0 software and calculating the extremal values of growth rates (storage) and those of exergy destruction and entropy creation. The results showed that the values of both maximum dissipation and maximum exergy progressed apace with that of maximum storage till the maturation of rice and became stable thereafter, whereas maximum residence time and maximum specific dissipation values initially decreased before their asymptotic rise. A similar pattern was also observed for the maximum specific exergy. However, the maximum power dissipation curve followed a highly fluctuated course before becoming stable on the maturation of rice

Investigating the Health of a Rice Field Ecosystem Using Thermodynamic Extremal Principles

This study investigates the dynamic behaviour of a rice field ecosystem and aims to define its integral features using the stability concept of an ecological goal function. This function is based on the extremal principles of thermodynamics, which assume that certain energetic processes of ecosystems—such as the rate of exergy destruction—are directed by the self-organizing informatics of the systems towards maxima or minima. In our study, we exploit the availability of substantially long time-series data relating to a rice field ecosystem to gain an evocative understanding of its growth trajectory in light of the thermodynamic principles. We accomplished this by constructing a model based on the STELLA 9.0 software and calculating the extremal values of growth rates (storage) and those of exergy destruction and entropy creation. The results showed that the values of both maximum dissipation and maximum exergy progressed apace with that of maximum storage till the maturation of rice and became stable thereafter, whereas maximum residence time and maximum specific dissipation values initially decreased before their asymptotic rise. A similar pattern was also observed for the maximum specific exergy. However, the maximum power dissipation curve followed a highly fluctuated course before becoming stable on the maturation of rice

Immunopathogenesis of corneal graft rejection

The most common cause of corneal graft failure is corneal graft rejection (CGR). Although cornea is one of the immune-privileged sites, it can still get a rejection episode due to a breach in its natural protective mechanism. Both anatomical and structural properties of cornea and anterior chamber contribute toward its immune tolerance. Clinically, every layer of the transplanted cornea can get a rejection episode. A proper understanding of immunopathogenesis will help in understanding the various mechanism of CGR and the development of newer strategies for the prevention and management of such cases

Terahertz Conductivity within Colloidal CsPbBr₃ Perovskite Nanocrystals: Remarkably High Carrier Mobilities and Large Diffusion Lengths

Colloidal CsPbBr₃ perovskite nanocrystals (NCs) have emerged as an excellent light emitting material in last one year. Using time domain and time-resolved THz spectroscopy and density functional theory based calculations, we establish 3-fold free carrier recombination mechanism, namely, nonradiative Auger, bimolecular electron–hole recombination, and inefficient trap-assisted recombination in 11 nm sized colloidal CsPbBr₃ NCs. Our results confirm a negligible influence of surface defects in trapping charge carriers, which in turn results into desirable intrinsic transport properties, from the perspective of device applications, such as remarkably high carrier mobility (∼4500 cm² V^–1 s^–1), large diffusion length (>9.2 μm), and high luminescence quantum yield (80%). Despite being solution processed and possessing a large surface to volume ratio, this combination of high carrier mobility and diffusion length, along with nearly ideal photoluminescence quantum yield, is unique compared to any other colloidal quantum dot system