Structural and functional Alterations of FLT3 in Acute Myeloid Leukemia

Hematopoiesis is highly regulated through cytokine-induced stimulation of multiple signal transduction pathways in order to mediate appropriate differentiation and proliferation of specific progenitor populations. Ligand-induced stimulation of the FMS-like tyrosine kinase 3 (FLT3) leads to activation of multiple downstream effector pathways resulting in differentiation and proliferation of specific progenitor cell populations. Genomic alterations of the FLT3 gene leads to autonomous receptor activation, dysregulation of FLT3 signal transduction pathways, contributes to myeloid pathogenesis, and have been linked to response to therapy and clinical outcome. Exploring the mechanisms by which these FLT3 alterations lead to dysregulated proliferation would provide a better understanding of the molecular pathogenesis of AML and may provide insights into potential therapeutic interventions

Non-exclusionary input prices

This paper models a vertically-integrated provider that is a monopoly supplier of an input that is essential for downstream production. An input price that is “too high” can lead to inefficient foreclosure and one that is “too low” creates incentives for non-price discrimination. The range of non-exclusionary input prices is circumscribed by the input prices generated on the basis of upper-bound and lower-bound displacement ratios. The admissible range of the ratio of downstream to upstream price-cost margins is increasing in the degree of product differentiation and reduces to a single ratio in the limit as the products become perfectly homogeneous

Oil Shocks and Stock Return Volatility

Citation: Bachmeier, L. J. and Nadimi, S.R.. (2018) Oil Shocks and Stock Return Volatility. Quarterly Review of Economics and Finance. Submitted Manuscript.Asset return volatility is important to the macroeconomy. This paper asks whether oil price volatility can be used as a predictor of stock return volatility. In contrast with previous research, we focus on the out-of-sample predictive power of oil price volatility rather than on in-sample inference. Formal tests of out-of-sample predictive ability find no evidence supporting the use of oil price volatility as a predictor of future stock return volatility. Further analysis using rolling window estimation and structural break tests shows that the coefficients of this relationship are very unstable. The coefficients can be positive, negative, or close to zero depending on the sample that is chosen. We discuss the implications of this finding for monetary policy

Computing the eigenvalues and eigenvectors of a fuzzy matrix

Computation of fuzzy eigenvalues and fuzzy eigenvectors of a fuzzy matrix is a challenging problem. Determining the maximal and minimal symmetric solution can help to find the eigenvalues. So, we try to compute these eigenvalues by determining the maximal and minimal symmetric solution of the fully fuzzy linear system $widetilde{A}widetilde{X}= widetilde{lambda} widetilde{X}.

Burden of traumatic spine fractures in Tehran, Iran.

UNLABELLED: ABSTRACT: BACKGROUND: The Disability-Adjusted Life Year (DALY) was designed by the World Health Organization (WHO) to measure, compare, and analyze the burden of various diseases. To the best of our knowledge, this is the first study on the assessment of burden of traumatic spinal fracture (TSF) in an Iranian community. We estimated burden of TSF includes both isolated (iTSF) and associated injuries related to traumatic spinal fractures (aTSF) in Tehran, the capital of Iran, for the year 2006-2007 using DALYs. METHODS: Burden of TSF was estimated based on information provided by the national data on Iranian trauma, data from the WHO, and literature data using disease modeling (DISMOD). Incidence of TSF and associated injuries were obtained from two population based studies and National Trauma Data Bank in Iran, while duration, and relative risk of mortality (RRM) were obtained from WHO data and the literature. The incidence, duration, and relative risk of mortality (RRM) were used to calculate DALY for TSF. To calculate DALY, the years of life lost because of premature mortality (YLL) were added to the number of years lost because of disability (YLD). DALYs were calculated separately for both iTSF and aTSF. In-hospital YLD and post-hospital YLL for iTSF and in-hospital YLL and YLD were calculated for aTSFs. RESULTS: TSF incidence was 16.35 (95%CI: 3.4-48.0) per 100,000. The incidence of TSF in males was more than twice that of females. The largest DALYs were seen in 15-29 years. The highest burden of associated injuries of TSF was related to spinal cord and head injury. DALYs for aTSF were estimated to be 2496.9 years (32.0 DALY/100,000 population). The YLD and YLL were almost similar. Total DALY for iTSF and aTSF was 2568.9 years (32.92 DALY/100,000 population). Based on the risk extracted from the literature, post-hospital increased risk of mortality was increased by 1318 DALY (16.89 DALY/100,000 population). CONCLUSION: This study showed a considerable burden for TSFs mainly due to associated injuries and increased lifelong RRM in patients with TSF

A scientometrics survey on project scheduling

In project management, a schedule is considered as a list a project's milestones, activities, and deliverables, normally with some start and finish time schedule, which are estimated by some information incorporated in the project schedule including resource allocation, budget, task duration, and linkages of dependencies and scheduled events. This paper presents a comprehensive review of the studies associated with project scheduling. The study uses Scopus database as a primary search engine and covers 3370 records over the period 1963-2019. The records are statistically analyzed and categorized in terms of different criteria. Based on the survey, "decision support systems" is the keyword which has carried the highest densities followed by heuristics methods. Among the most cited articles, papers published by researchers in Germany have received the highest citations (9084), followed by United States (7058) and Belgium with 4853 citations