Prevalence of Lumbosacral Transitional Vertebra in Individuals with Low Back Pain: Evaluation Using Plain Radiography and Magnetic Resonance Imaging

Study DesignDescriptive cross-sectional study.PurposeTo determine the frequency of lumbosacral transitional vertebrae (LSTV) in patients with low back pain (LBP) and the role of iliolumbar ligament (ILL) origin from L5 in LSTV cases.Overview of LiteratureTransitional vertebrae are developmental variants of the spine. LSTV is a common congenital abnormality, and failure to recognize this anomaly may result in serious consequences during surgery.MethodsAll patients aged 11–90 years of either gender with LBP for any duration, who presented for X-ray and magnetic resonance imaging (MRI) of the lumbosacral spine, were included. X-rays of the lumbosacral spine in anteroposterior and lateral views were acquired. In addition, T1- and T2-weighted sagittal and axial MRI was performed. Images were evaluated on a workstation.ResultsOf 504 patients, transitional vertebrae were observed in 75 patients (15%). Among them, 39 (52%) patients had Castellvi type III and 36 (48%) patients had Castellvi type II. However, on MRI, 42 (56%) patients had O'Driscoll type II, 18 (24%) patients had O'Driscoll type IV, and 15 patients (20%) had O'Driscoll type III. ILL origin from L5 was significantly higher (n=429, 100%) among patients with a normal lumbosacral junction than among patients with a transitional lumbosacral junction (n=22, 29.3%) (p<0.001).ConclusionsLSTV occurs at a high frequency in patients with LBP. Furthermore, in the presence of LSTV, the ILL is not a reliable marker for the identification of L5

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

Mathematical Modelling and Optimisation of Low-Temperature Drying on Quality Aspects of Rough Rice

Rice when harvested normally has a high moisture content of 20–25% which requires immediate drying, reducing its mass loss and preventing it to spoil. This situation is more crucial with the areas under humid tropical conditions, where moisture and temperature mainly play an important role in deteriorating the quality of rough rice. Keeping the importance of quality attributes of rough rice, the study was carried out to assess the effects of low-temperature drying and suggest an optimum condition. Response surface methodology (RSM) with a central composite design was employed to study the effects of variables, i.e., temperature (X1), time (X2), and air velocity (X3) on responses, i.e., head rice yield (HRY), hardness, lightness, and cooking time. The experimental data were fitted to the quadratic model, studying the relationship between independent and dependent variables. The results revealed that the HRY, hardness, lightness, and cooking time increased with increasing variables, whereas for HRY, it particularly increased and then decreased. It was observed that temperature had more influence on the quality of rough rice followed by time and velocity. Results for analysis of variance revealed that the quality aspects of rough rice were significantly (p<0.05) affected by temperature and time, whereas for velocity, it only significantly affected hardness. The optimal drying conditions predicted by RSM for variables were 25°C, 600 min, and 1 m·s−1, and the optimal predicted HRY, hardness, lightness, and cooking time were 73.93%, 38.28 N, 71.40, and 27.58 min respectively. Acceptable values of R2, Adj R2, and nonsignificance of lack of fit demonstrated that the model applied was adequate and can be used for optimization. The study concluded that the RSM with a central composite design was successfully used to study the dependence of quality aspects of rough rice at low temperature and can be utilized by the rice processing industries

Application of X-Ray Computed Tomography for Analyzing Cleats and Pores for Coalbed Methane in Coal from Thar Coalfield

The CT (Computed Tomography) is a non-destructive technique that can provide information of internal structure of coal in two-dimensional, this technology is now widely used in geoscientific research. This technique is used for the measuring cleat dimension and pore width of the Thar coal. The slicing study of Thar coal shows that the length of cleats in various seams ranges from 0.5-5mm and the aperture of these cleats vary between 0.1-0.5mm. The porosity also plays an important role in storage and production of coalbed methane, the size or width of pores in coal under investigation ranges between 0.1-0.7mm. The present investigation shows that Seam-III and V of the can be considered as viable as hold a potential for CBM (Coalbed Methane) resources, however, the coal samples from these seams need to be analyzed for the presence of methane In Thar coalfield, the pore volume ranges from 0.06-2.36 cc/g and pore diameter in Thar coal ranges from meso-pore and macro-pore (34.81-121.51Å). These meso and macro-pores serve as transport pathways, and little methane is stored in these pores in the adsorbed stat

Evaluation of Physico-Mechanical Characteristics of Different Paddy Cultivars Grown in Humid Subtropical Region of Eastern China

Background: Paddy during various stages i.e. loading, transportation, storage, handling etc. occurs severe losses, which can be reduced by designing appropriate post-harvest machineries using physico-mechanical properties. Objectives: The study aimed to assess the variation in physico-mechanical properties of thirteen different paddy cultivars. Methodology: The study was carried out at the College of Engineering, Nanjing Agricultural University, China. Thirteen different freshly harvested paddy cultivars were collected from Nanjing. Collected paddy cultivars before experiment were cleaned removing extraneous materials. Paddy cultivars were sealed polythene bags, and were then kept in refrigerator at a temperature of 5 ºC for 7 days for uniform distribution of moisture. The required amount of samples from each cultivar was accordingly taken for evaluating their physical and mechanical properties. Results: The results when assessed were statistically different (p?0.05) from each other. The average values of different paddy cultivars for length, width, thickness, geometric mean diameter, arithmetic mean diameter, square mean diameter, equivalent diameter, surface area, volume, sphericity, aspect ratio, thousand kernel weight, bulk density, true density, porosity, hardness and toughness (for both horizontal and vertical orientations) were calculated to be 7.94mm, 3.32mm, 2.26mm, 3.84mm, 4.51mm, 2.56mm, 3.64mm, 46.53mm2, 29.74mm3, 0.49%, 0.42, 28.64 gm, 568.31 kg m-3, 1225.20 kg m-3, 54%, 46.09 N, 14.75 N, 16.06 mJ and 6.90 mJ respectively. Conclusion: A wide variation was observed for each parameter while comparing different paddy cultivars. This wide variation in result will negatively affect the performance of the equipment and machinery being used for post-harvest practices. The study concludes that it is essential for industries involved in equipment design and machinery production, as well as end-users responsible for their implementation, to take into account these substantial differences among cultivars when making their decisions

A framework to analyse digital fabrication projects:the role of design creativity

Abstract In this study, we formulate a framework to evaluate open-ended projects related to digital fabrication. The framework consists of two dimensions, i.e. human intellect and technology. Human intellect is judged by three sub-dimensions — creativity, computational thinking, and skills. In order to study the technology dimension, the four sub-dimensions include process, outcome, development stage, and reproducibility. To test the proposed framework, a case study was applied on digital fabrication projects done in Fab Academy 2019. Final projects of students are selected to implement the framework since final projects exemplify most of the skills learned by a student of the digital fabrication course. In addition, the proposed framework is also assessed in the light of existing literature done to evaluate learning in similar types of projects. The results establish the relationship among different sub parameters of human intellect and technology, and present the open-ended project evaluation results

Sustainable design and prototyping using digital fabrication tools for education

Abstract Prototyping physical artifacts is a fundamental activity for both product development in industrial and engineering design domains and the development of digital fabrication skills. Prototyping is also essential for human-centric problem-solving in design education. Digital fabrication assists in rapid prototype development through computer-aided design and manufacturing tools. Due to the spread of makerspaces like fabrication laboratories (FabLabs) around the world, the use of digital fabrication tools for prototyping in educational institutes is becoming increasingly common. Studies on the social, environmental, and economic sustainability of digital fabrication have been carried out. However, none of them focus on sustainability and prototyping-based digital fabrication tools or design education. To bridge this research gap, a conceptual framework for sustainable prototyping based on a five-stage design thinking model is proposed. The framework, which is based on a comprehensive literature review of social, economic, and environmental sustainability factors of digital fabrication, is applied to evaluate a prototyping process that took place in a FabLab in an education context aimed at enhancing sustainability. Three case studies are used to evaluate the proposed framework. Based on the findings, recommendations are presented for sustainable prototyping using digital fabrication tools

Designing and integrating electronics for bespoke rehabilitation experiences in virtual reality

Abstract Available virtual reality (VR) input devices, such as controllers enabling user interaction with the virtual environment, typically do not meet the requirements for rehabilitation. The therapeutic exercises used in the treatment of neurological disorders (e.g., stroke or musculoskeletal injuries) are mainly associated with rehabilitating the muscles of the arm, wrist, and fingers. Design requirements for devising a therapeutic interaction technique for VR rehabilitation training systems (RTSs) include sensing, identifying other input requirements, and setting exercise parameters using outputs. Therefore, dedicated electronics solutions are needed to meet the needs of bespoke rehabilitation experiences in VR. In this study, therapeutic interaction requirements were identified by exploring therapeutic exercises. The aim is to provide a dedicated electronics solution incorporating input and output systems developed for therapeutic purposes. We identify design requirements to be considered when designing and implementing electronics for rehabilitation training in VR. These cover power, connectivity, modularity, and operational and physical design requirements. The proposed electronics solution fulfills these requirements and is integrated into a bespoke controller for VR rehabilitation. Furthermore, in this article, we (1) provide a set of design principles for designing a therapeutic interaction technique for VR headsets; (2) describe the process involved in the design and integration of electronics for bespoke rehabilitation experiences; (3) demonstrate how the electronics meet the requirements of the prototyping development process; and (4) describe the design and working principles and integration of custom electronics in a bespoke controller for VR rehabilitation. The proposed electronics solution fulfills the requirements of bespoke controller designs and provides per-patient customized interactions. Moreover, the solution allows for adjustment of the level of the rehabilitation exercises using outputs and recording of the patient performance data, which can be utilized by therapists

A systematic review on FabLab environments and creativity:implications for design

Abstract Fabrication laboratories (FabLabs) and makerspaces are used to transform ideas into tangible products. Used in a design–learning context, they can enhance cognitive and creative skills. Creativity is the pivotal ability to produce innovative outcomes in makerspaces, and several studies have attempted to understand the role of makerspaces and creativity in specific fields. However, a comprehensive study offering a holistic view of the contributions of the makerspaces as built environments that foster creativity is lacking. Therefore, we conducted a systematic literature review on FabLabs, makerspaces, and creativity to address this research gap. While the review was performed using five major databases, only peer reviewed journal articles were considered. The findings revealed that makerspaces help to develop person, product, physical, and social environments, as well as process aspects of creativity. Moreover, makerspaces induce problem solving, collaborative, and communication skills; they also offer appealing environments and technologies for developing creative solutions to real-life problems. We identified and analysed five major themes dealing with technical skills, technological and environmental elements, STEM learning, and skill development, and elaborated upon their importance for enhancing creativity in FabLab and makerspace environments

Creativity methods adoption in higher education:perspectives of educators and students

Abstract Numerous higher education institutions offer courses aimed at enhancing learners’ creativity, especially in design studies. However, the differences in the adoption of creativity methods in teaching from educators’ and students’ perspectives are still underexplored. In this study, we used a custom-designed online survey questionnaire to understand educator and student perceptions of creativity methods in creativity-related courses in higher education. Our study results indicate apparent differences between students and instructors regarding their motivations for participating in creativity-related courses, preferences for the most effective creativity methods, and evaluations of creativity methods. We believe that our study results suggest helpful directions for the teaching of creativity methods in higher education