Primary hepatocellular carcinoma in HBV infected patient - a case report

Hepatocellular carcinoma is primary neoplasm of the liver, which usually accompanies cirrhosis of this organ. This malignancy neoplasms commonly occurs all around the world. The frequency of morbidity on this disease is correlated with frequency of HBV and HCV infections in the population. That is caused due to the pathogenic effects of these viruses, among others on liver cells, affecting carcinogenesis. Appropriate and early treatment of infection reduces the chance of developing cancer. In our article we present the case, 63-years-old male, with primary hepatocellular carcinoma correlated with hepatitis B virus infection. Unfortunately, the neoplasm was diagnosed too late, and despite the comprehensive treatment introduced, the patient died

Assessment of the knowledge about HIV-infectious materials in Poland

Malignancies were one of the earliest diagnosed manifestations that resulted in the description of acquired immunodeficiency syndrome (AIDS). Most cancers in AIDS patients are associated with coinfection with oncogenic viruses. Knowledge and public awareness about HIV infectious materials are important elements in preventing the spread of HIV infections. The aim of the study was to assess the knowledge about HIV infectious materials among three populations in Poland. A Poland-wide on-line survey was conducted and 2205 anonymous answers were analysed. Almost half of the answers came from students, of which 40% were medical students

Hepatic Chemerin and Chemokine-Like Receptor 1 Expression in Patients with Chronic Hepatitis C

Introduction. Chemerin seems to be involved in pathogenesis of chronic hepatitis C (CHC). Hepatic expressions of chemerin and its receptor, chemokine receptor-like 1 (CMKLR1), in CHC have not been studied so far. Aim. To evaluate chemerin and CMKLR1 hepatic expression together with serum chemerin concentration in CHC patients and to assess their relationship with metabolic and histopathological abnormalities. Methods. The study included 63 nonobese CHC patients. Transcription of chemerin and CMKLR1 was assessed by quantitative real-time PCR, while serum chemerin was assessed by enzyme-linked immunosorbent assay. Results. Expression of chemerin and CMKLR1 was present in the liver of all CHC patients regardless of sex or age. This expression was not associated with necroinflammatory activity and steatosis grade, fibrosis stage, and metabolic abnormalities. There was a negative association between serum chemerin and chemerin hepatic expression (r = (−0.41), P = 0.006). Conclusion. The study for the first time confirmed a marked expression of chemerin and CMKLR1 in the liver of CHC patients. The study was performed using the homogenates of human liver tissue, so it is not possible to define whether hepatocytes or other cell types which are abundantly represented in the liver constitute the main source of chemerin and CMKLR1 mRNA