Does Where You Live Make You Fat? Obesity and Access to Chain Grocers

This paper investigates the role that aspects of the physical environment play in determining health outcomes in adults as measured by body mass index (BMI). Using spatial econometric techniques that allow for spatial spillovers and feedback processes, this research specifically examines how differing levels of access to large chain grocers has on individual health outcomes. While other studies have investigated the impact of proximity to food retailers, the pointcoordinate data used in this paper is uniquely suited to spatial econometric estimation at the individual level. In addition to modeling spatial dependence and allowing for unobserved neighborhood effects, the flexibility of the model is increased by incorporating potential spatial heterogeneity between wealthier and lower-income neighborhoods. Using survey responses tied to geographic location, demographic, behavioral, and access to chain grocers, this study finds evidence of spatial dependence pointing to locational impacts on BMI. The effect on individual health outcomes of retailer access improvements varies depending on neighborhood characteristics. Our findings suggest structural differences in the variation and sensitivity of BMI dependent jointly on individual and neighborhood characteristics.body mass index, obesity, spatial dependence, obesogenic environments

Obesity in Urban Food Markets: Evidence from Geo-referenced Micro Data

This paper provides quantitative estimates of the effect of proximity to fast food restaurants and grocery stores on obesity in urban food markets. Our empirical model combined georeferenced micro data on access to fast food restaurants and grocery stores with data about salient personal characteristics, individual behaviors, and neighborhood characteristics. We defined a "local food environment" for every individual utilizing 0.5-mile buffers around a person's home address. Local food landscapes are potentially endogenous due to spatial sorting of the population and food outlets, and the body mass index (BMI) values for individuals living close to each other are likely to be spatially correlated because of observed and unobserved individual and neighborhood effects. The potential biases associated with endogeneity and spatial correlation were handled using spatial econometric estimation techniques. Our policy simulations for Indianapolis, Indiana, focused on the importance of reducing the density of fast food restaurants or increasing access to grocery stores. We accounted for spatial heterogeneity in both the policy instruments and individual neighborhoods, and consistently found small but statistically significant effects for the hypothesized relationships between individual BMI values and the densities of fast food restaurants and grocery stores.obesity, fast food, grocery store, spatial econometrics, micro data, Agricultural and Food Policy, Community/Rural/Urban Development, Consumer/Household Economics, Food Consumption/Nutrition/Food Safety, Health Economics and Policy, Public Economics, Research Methods/ Statistical Methods, C31, D12, I12, I18,

The synthesis and thermal decomposition of 3, 3-disubstituted-[delta]'-pyrazolines

Thesis (Ph.D.)--Boston University[delta]'-Pyrazolines were prepared in which one or more of the groups R, Rl, R2, R3 are alkyl or phenyl and the other groups are hydrogen. In addition, the molecule was modified by the use of four other activating groups in the place of the carboxyl group, i.e. -CN, -CONH2 , -COCH3, and -No2. The compounds were decomposed thermally and the kinetics of the decomposition was followed by measuring the volume of nitrogen evolved as a function of time. From the data obtained, the rate constants and energies of activation were calculated. The purpose of the investigation was to determine the effects upon the rate constants and energies of activation produced by the alteration of the molecule at the above-indicated positions. The pyrazolines were prepared by the addition of diazomethane to the appropriate olefin, or by the addition of the appropriate diazoalkane to ethyl methacrylate. [TRUNCATED

The Ursinus Weekly, March 8, 1907

Thoughts on Bomberger Hall • Concert postponed • Revised rules for special and extended examinations • Minute on the death of Director Anders • Intercollegiate oratorical contest • Married • 1908 Ruby • Society notes • Alumni notes • Special notice • Baseball practice • Class honors • Goethe\u27s philosophyhttps://digitalcommons.ursinus.edu/weekly/2935/thumbnail.jp

Optimal 2,3-Trees

The 2,3-trees that are optimal in the sense of having minimal expected number of nodes visited per access are characterized in terms of their “profiles”. The characterization leads directly to a linear-time algorithm for constructing a K-key optimal 2,3-tree for a sorted list of K keys. A number of results are derived that demonstrate how different in structure these optimal 2,3-trees are from their “average” cousins

z~2: An Epoch of Disk Assembly

We explore the evolution of the internal gas kinematics of star-forming galaxies from the peak of cosmic star-formation at $z\sim2$ to today. Measurements of galaxy rotation velocity $V_{rot}$, which quantify ordered motions, and gas velocity dispersion $\sigma_g$, which quantify disordered motions, are adopted from the DEEP2 and SIGMA surveys. This sample covers a continuous baseline in redshift from $z=2.5$ to $z=0.1$, spanning 10 Gyrs. At low redshift, nearly all sufficiently massive star-forming galaxies are rotationally supported ($V_{rot}>\sigma_g$). By $z=2$, the percentage of galaxies with rotational support has declined to 50$\%$ at low stellar mass ($10^{9}-10^{10}\,M_{\odot}$) and 70$\%$ at high stellar mass ($10^{10}-10^{11}M_{\odot}$). For $V_{rot}\,>\,3\,\sigma_g$, the percentage drops below 35$\%$ for all masses. From $z\,=\,2$ to now, galaxies exhibit remarkably smooth kinematic evolution on average. All galaxies tend towards rotational support with time, and it is reached earlier in higher mass systems. This is mostly due to an average decline in $\sigma_g$ by a factor of 3 since a redshift of 2, which is independent of mass. Over the same time period, $V_{rot}$ increases by a factor of 1.5 for low mass systems, but does not evolve for high mass systems. These trends in $V_{rot}$ and $\sigma_g$ with time are at a fixed stellar mass and should not be interpreted as evolutionary tracks for galaxy populations. When galaxy populations are linked in time with abundance matching, not only does $\sigma_g$ decline with time as before, but $V_{rot}$ strongly increases with time for all galaxy masses. This enhances the evolution in $V_{rot}/\sigma_g$. These results indicate that $z\,=\,2$ is a period of disk assembly, during which the strong rotational support present in today's massive disk galaxies is only just beginning to emerge.Comment: 12 pages, 8 figures, submitted to Ap

AN ANALYSIS of the 20-year use of a deep Broward County lime-rock pit as a natural advanced wastewater treatment and groundwater recycling facility, with a recommendation that: with the large number of similar lime-rock pits in Southeast Florida, the opportunity for expanding the benefits of such inland wastewater retention should be given serious consideration instead of wastefully discharging the water into the ocean.

The benefits of the inland retention of freshwaters in South Florida are indisputable. During periods of prolonged drought, the maintenance of a higher groundwater table, which benefits terrestrial vegetation and retards saltwater intrusion, is clearly preferable to the alternative of discharging up to 400,000 gallons of freshwater per day into the ocean. Therefore, the only objections to the retention of treated sewage effluent in an inland lime-rock pit, with the physical, chemical and biologic characteristics of our pits, would have to do with possible detrimental effects to public health or the environment. The major public health concern involves the possible discharge of human pathogens. This can be prevented by high-level chlorination of well-treated effluent such as that of the Ferncrest Utilities. With the cooperation and help of the Nova University Oceanographic Center, the Florida Agricultural Research and Education Station, the Broward County Environmental Quality Control Board and the landowners, the Tindall Hammock Irrigation and Soil Conservation District and the Ferncrest Utilities respectfully submit that retention of the excellent tertiary-treated Ferncrest Utilities effluent in such a lime-rock pit accomplishes the following: • Provides an inexpensive, safe, practical, alternative, non-structural, natural, and environmentally sound drainage and wastewater pollutant treatment and inactivation facility that uses no energy except sunlight. • Conserves, stores and recycles stormwater and wastewater instead of wasteful discharge into canals or the ocean. • Helps to maintain a higher groundwater elevation, thereby reducing the volume of irrigation water needed for area lawns and shrubbery, and the energy and expense thereof. • Retards the rate of saltwater intrusion into the aquifer. • Enhances the U.S. EPA\u27s goal of fishable, swimmable public waters by complexing and precipitating runoff and wastewater pollutants, thereby keeping them out of the North New River Canal, the New River and the ocean. With the large number of similar lime-rock pits in Southeast Florida, the opportunity for expanding the benefits of such inland wastewater retention should be given serious consideration

Efficient yeast ChIP-Seq using multiplex short-read DNA sequencing

<p>Abstract</p> <p>Background</p> <p>Short-read high-throughput DNA sequencing technologies provide new tools to answer biological questions. However, high cost and low throughput limit their widespread use, particularly in organisms with smaller genomes such as <it>S. cerevisiae</it>. Although ChIP-Seq in mammalian cell lines is replacing array-based ChIP-chip as the standard for transcription factor binding studies, ChIP-Seq in yeast is still underutilized compared to ChIP-chip. We developed a multiplex barcoding system that allows simultaneous sequencing and analysis of multiple samples using Illumina's platform. We applied this method to analyze the chromosomal distributions of three yeast DNA binding proteins (Ste12, Cse4 and RNA PolII) and a reference sample (input DNA) in a single experiment and demonstrate its utility for rapid and accurate results at reduced costs.</p> <p>Results</p> <p>We developed a barcoding ChIP-Seq method for the concurrent analysis of transcription factor binding sites in yeast. Our multiplex strategy generated high quality data that was indistinguishable from data obtained with non-barcoded libraries. None of the barcoded adapters induced differences relative to a non-barcoded adapter when applied to the same DNA sample. We used this method to map the binding sites for Cse4, Ste12 and Pol II throughout the yeast genome and we found 148 binding targets for Cse4, 823 targets for Ste12 and 2508 targets for PolII. Cse4 was strongly bound to all yeast centromeres as expected and the remaining non-centromeric targets correspond to highly expressed genes in rich media. The presence of Cse4 non-centromeric binding sites was not reported previously.</p> <p>Conclusion</p> <p>We designed a multiplex short-read DNA sequencing method to perform efficient ChIP-Seq in yeast and other small genome model organisms. This method produces accurate results with higher throughput and reduced cost. Given constant improvements in high-throughput sequencing technologies, increasing multiplexing will be possible to further decrease costs per sample and to accelerate the completion of large consortium projects such as modENCODE.</p