Dynamics of local grid manipulations for internal flow problems

The control point method of algebraic grid generation is briefly reviewed. The review proceeds from the general statement of the method in 2-D unencumbered by detailed mathematical formulation. The method is supported by an introspective discussion which provides the basis for confidence in the approach. The more complex 3-D formulation is then presented as a natural generalization. Application of the method is carried out through 2-D examples which demonstrate the technique

Rural communities and awareness of DOE environmental management programs at the Nevada Test Site: Do outreach efforts matter?

Are residents living in communities around the Nevada Test Site aware of environmental remediation activities and do outreach efforts contribute to awareness? Through a U.S. Department of Energy (DOE) grant, the University of Nevada, Las Vegas administered a mail questionnaire to 14,083 residents and received 1,721 responses. Approximately 90% of the respondents reported awareness of past nuclear tests at the Nevada Test Site; 63% reported awareness of low-level radioactive waste disposal at the site; and 41% are aware that the Yucca Mountain Project for high level waste disposal is part of the Office of Civilian Radioactive Waste Management and not part of the Office of Environmental Management. Using both logit and probit regression models, at a 1% level of significance, respondents who reported obtaining information from the Community Advisory Board for Nevada Test Site Programs are more likely to be knowledgeable about low-level radioactive waste disposal activities and are more likely to be knowledgeable that the missions of the Office of Environmental Management and Office of Civilian Radioactive Waste Management are different

Remodelling of the natural product fumagillol employing a reaction discovery approach

In the search for new biologically active molecules, diversity-oriented synthetic strategies break through the limitation of traditional library synthesis by sampling new chemical space. Many natural products can be regarded as intriguing starting points for diversity-oriented synthesis, wherein stereochemically rich core structures may be reorganized into chemotypes that are distinctly different from the parent structure. Ideally, to be suited to library applications, such transformations should be general and involve few steps. With this objective in mind, the highly oxygenated natural product fumagillol has been successfully remodelled in several ways using a reaction-discovery-based approach. In reactions with amines, excellent regiocontrol in a bis-epoxide opening/cyclization sequence can be obtained by size-dependent interaction of an appropriate catalyst with the parent molecule, forming either perhydroisoindole or perhydroisoquinoline products. Perhydroisoindoles can be further remodelled by cascade processes to afford either morpholinone or bridged 4,1-benzoxazepine-containing structures.P50 GM067041 - NIGMS NIH HHS; P50 GM067041-07 - NIGMS NIH HHS; P50 GM067041-08 - NIGMS NIH HHS; P50 GM067041-09 - NIGMS NIH HH

Wave localization in binary isotopically disordered one-dimensional harmonic chains with impurities having arbitrary cross section and concentration

The localization length for isotopically disordered harmonic one-dimensional chains is calculated for arbitrary impurity concentration and scattering cross section. The localization length depends on the scattering cross section of a single scatterer, which is calculated for a discrete chain having a wavelength dependent pulse propagation speed. For binary isotopically disordered systems composed of many scatterers, the localization length decreases with increasing impurity concentration, reaching a mimimum before diverging toward infinity as the impurity concentration approaches a value of one. The concentration dependence of the localization length over the entire impurity concentration range is approximated accurately by the sum of the behavior at each limiting concentration. Simultaneous measurements of Lyapunov exponent statistics indicate practical limits for the minimum system length and the number of scatterers to achieve representative ensemble averages. Results are discussed in the context of future investigations of the time-dependent behavior of disordered anharmonic chains.Comment: 8 pages, 10 figures, submitted to PR

High-temperature liquid-mercury cathodes for ion thrusters Quarterly progress report, 1 Dec. 1966 - 28 Feb. 1967

High temperature liquid mercury cathodes for ion thrusters - thermal design analysi

Gallium(III)-Promoted Halocyclizations of 1,6-Diynes

Adrian Landreth was an REU student, summer 2014Cyclization of 1,6-diynes promoted by stoichiometric Ga(III) halides produces vinyl halides in good to excellent yields. Under acidic conditions, initially formed iodocyclization products undergo in situ Friedel-Crafts cyclizations, giving access to iodo-indenopyridines. The application of the vinyl halides in cross-coupling reactions has been explored, and mechanistic aspects of the cyclization are discussed.HIGMS CMLD Initiative (P50 GM067041) NSF REU - Adrian Landreth support (CHE 1156666) NSF - NMR purchase (CHE 0619339) NSF - HRMS purchase (CHE0443618

Gender Differences in Isokinetic Strength after 60 and 90 d Bed Rest

Recent reports suggest that changes in muscle strength following disuse may differ between males and females. PURPOSE: To examine potential gender differences in strength changes following 60 and 90 d of experimental bed rest. METHODS: Isokinetic extensor and flexor strength of the knee (60deg and 180deg/s, concentric only), ankle (30deg/s, concentric and eccentric), and trunk (60deg/s, concentric only) were measured following 60 d (males: n=4, 34.5+/-9.6 y; females: n=4, 35.5+/-8.2 y) and 90 d (males: n=10, 31.4+/-4.8 y; females: n=5, 37.6+/-9.9 y) of 6-degree head-down-tilt bed rest (BR; N=23). Subjects were fed a controlled diet (55%/15%/ 30%, CHO/PRO/FAT) that maintained body weight within 3% of the weight recorded on Day 3 of bed rest. After a familiarization session, testing was conducted 6 d before BR and 2 d after BR completion. Peak torque and total work were calculated for the tests performed. To allow us to combine data from both 60- and 90-d subjects, we used a mixed-model statistical analysis in which time and gender were fixed effects and bed rest duration was a random effect. Log-transformations of strength measures were utilized when necessary in order to meet statistical assumptions. RESULTS: Main effects were seen for both time and gender (p<0.05), showing decreased strength in response to bed rest for both males and females, and males stronger than females for most strength measures. Only one interaction effect was observed: females exhibited a greater loss of trunk extensor peak torque at 60 d versus pre-BR, relative to males (p=0.004). CONCLUSION: Sixty and 90 d of BR induced significant losses in isokinetic muscle strength of the locomotor and postural muscles of the knee, ankle, and trunk. Although males were stronger than females for most of the strength measures that we examined, only changes in trunk extensor peak torque were greater for females than males at day 60 of bed res