9,694 research outputs found
A method for predicting the stability characteristics of an elastic airplane. Volume 4: FLEXSTAB 1.02.00 demonstration case and results
What American Psychological Association Leaders Have to Say About Psychology of Religion and Spirituality
What do American Psychological Association (APA) leaders have to say about the new journal Psychology of Religion and Spirituality? A survey was sent to 204 current APA council representatives and divisional residents, yielding 63 completed questionnaires (31% response rate). Respondents generally affirmed the importance of religion and spirituality as topics of inquiry in psychology. Although not highly religious themselves, respondents recognize religion and spirituality as important aspects of human diversity. In considering the new journal, current APA leaders who responded to the survey are particularly interested in articles relating religion and spirituality to health and coping and articles considering cross-cultural and interfaith issues
COVID-19 and non-COVID ARDS patients demonstrate a distinct response to low dose steroids- A retrospective observational study
Patients with COVID-19 ARDS have distinct physiological and immunological phenotypes compared to patients with non-COVID ARDS. Patients with COVID-19 ARDS (n = 32) had a significant improvement in PaO2: FiO2 ratio (p = 0.046) following low-dose steroid treatment, unlike patients with non-COVID ARDS (n = 16) (p = 0.529). Patients with COVID-19 ARDS had a greater fall in CRP compared to patients with non-COVID ARDS, albeit not statistically significant (p = 0.07). Our novel findings highlight differences in the underlying physiological and immunological phenotypes between COVID-19 and non-COVID ARDS, with implications for future ARDS studies
Hard X-ray flares in IGR J08408-4503 unveil clumpy stellar winds
Context : A 1000-s flare from a new hard X-ray transient, IGR J08408-4503,
was observed by INTEGRAL on May 15, 2006 during the real-time routine
monitoring of IBIS/ISGRI images performed at the INTEGRAL Science Data Centre.
The flare, detected during a single one-hour long pointing, peaked at 250 mCrab
in the 20-40 keV energy range.
Aims : Multi-wavelength observations, combining high-energy and optical data,
were used to unveil the nature of IGR J08408-4503.
Methods : A search in all INTEGRAL public data for other bursts from IGR
J08408-4503 was performed, and the detailed analysis of another major flare is
presented. The results of two Swift Target of Opportunity observations are also
described. Finally, a study of the likely optical counterpart, HD 74194, is
provided.
Results : IGR J08408-4503 is very likely a supergiant fast X-ray transient
(SFXT) system. The system parameters indicate that the X-ray flares are
probably related to the accretion of wind clumps on a compact object orbiting
about 1E13 cm from the supergiant HD 74194. The clump mass loss rate is of the
order of 1E-6 solar mass/yr.
Conclusions : Hard X-ray flares from SFXTs allow to probe the stellar winds
of massive stars, and could possibly be associated with wind perturbations due
to line-driven instabilities.Comment: 5 pages with 5 figures. Published as a Letter in Astronomy &
Astrophysic
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Safety and Pharmacokinetics of a Four Monoclonal Antibody Combination Against Botulinum C and D Neurotoxins.
Botulism is caused by botulinum neurotoxin (BoNT), the most poisonous substance known. BoNTs are also classified as Tier 1 biothreat agents due to their high potency and lethality. The existence of seven BoNT serotypes (A-G), which differ between 35% to 68% in amino acid sequence, necessitates the development of serotype specific countermeasures. We present results of a Phase 1 clinical study of an anti-toxin to BoNT serotypes C and D, NTM-1634, which consists of an equimolar mixture of four fully human IgG1 monoclonal antibodies (mAbs), each binding to non-overlapping epitopes on BoNT serotypes C and D resulting in potent toxin neutralization in rodents. This first-in-human study evaluated the safety and pharmacokinetics of escalating doses of NTM-1634 administered intravenously to healthy adults (NCT03046550). Three cohorts of eight healthy subjects received a single intravenous dose of NTM-1634 or placebo at 0.33 mg/kg, 0.66 mg/kg or 1 mg/kg. Follow-up examinations and pharmacokinetic evaluations were continued up to 121 days post-infusion. Subjects were monitored using physical examinations, hematology and chemistry blood tests, and electrocardiograms. Pharmacokinetic parameters were estimated using noncompartmental methods. The results demonstrated that the materials were safe and well-tolerated with the expected half-lives for human mAbs and with minimal anti-drug antibodies detected over the dose ranges and duration of the study
Theoretical study of the dynamic structure factor of superfluid 4He
We study the dynamic structure factor of superfluid 4He
at zero temperature in the roton momentum region and beyond using
field-theoretical Green's function techniques. We start from the
Gavoret-Nozi\`{e}res two-particle propagator and introduce the concept of
quasiparticles. We treat the residual (weak) interaction between quasiparticles
as being local in coordinate space and weakly energy dependent. Our
quasiparticle model explicitly incorporates the Bose-Einstein condensate. A
complete formula for the dynamic susceptibility, which is related to , is derived. The structure factor is numerically calculated
in a self-consistent way in the special case of a momentum independent
interaction between quasiparticles. Results are compared with experiment and
other theoretical approaches.Comment: 17 pages, 16 figure
Momentum distributions in ^3He-^4He liquid mixtures
We present variational calculations of the one-body density matrices and
momentum distributions for ^3He-^4He mixtures in the zero temperature limit, in
the framework of the correlated basis functions theory. The ground-state wave
function contains two- and three-body correlations and the matrix elements are
computed by (Fermi)Hypernetted Chain techniques. The dependence on the ^3He
concentration (x_3) of the ^4He condensate fraction and of the
^3He pole strength (Z_F) is studied along the P=0 isobar. At low ^3He
concentration, the computed ^4He condensate fraction is not significantly
affected by the ^3He statistics. Despite of the low x_3 values, Z_F is found to
be quite smaller than that of the corresponding pure ^3He because of the strong
^3He-^4He correlations and of the overall, large total density \rho. A small
increase of along x_3 is found, which is mainly due to the decrease
of \rho respect to the pure ^4He phase.Comment: 23 pages, 7 postscript figures, Revte
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