50 research outputs found

    Reducing the drink driving road toll : a case study in integrating communication and social policy enforcement

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    This thesis presents a case study of the drink drive initiatives, including marketing communications, legislation and enforcement practices implemented in the state of Victoria (Australia) between 1989-2000. It has been argued that the 51% reduction in road toll was related to these initiatives. In order to explore the veracity of these claims, a holistic case study approach was adopted. In addition to an examination of the communications tactics and extant practices of enforcement agencies, the study involved interviews with two distinct groups: professionals in various fields pertaining to road safety, and members of the general Victorian driving community. The focus of this work was on the advertising and communications campaigns that were run by the Transport Accident Commission from 1989-2000; however the policy and enforcement initiatives were also examined in terms of the ir potential impact on the lowering of the road toll. Suggestions for the improvement of policy and communication strategies within a social marketing context are made

    Repair and Regeneration of the Respiratory System: Complexity, Plasticity, and Mechanisms of Lung Stem Cell Function

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    Respiratory disease is the third leading cause of death in the industrialized world. Consequently, the trachea, lungs, and cardiopulmonary vasculature have been the focus of extensive investigations. Recent studies have provided new information about the mechanisms driving lung development and differentiation. However, there is still much to learn about the ability of the adult respiratory system to undergo repair and to replace cells lost in response to injury and disease. This review highlights the multiple stem/progenitor populations in different regions of the adult lung, the plasticity of their behavior in injury models, and molecular pathways that support homeostasis and repair

    Reducing drink driving road deaths: Integrating communication and social policy enforcement in Australia

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    Lithium and Therapeutic Targeting of GSK-3

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    Lithium salts have been in the therapeutic toolbox for better or worse since the 19th century, with purported benefit in gout, hangover, insomnia, and early suggestions that lithium improved psychiatric disorders. However, the remarkable effects of lithium reported by John Cade and subsequently by Mogens Schou revolutionized the treatment of bipolar disorder. The known molecular targets of lithium are surprisingly few and include the signaling kinase glycogen synthase kinase-3 (GSK-3), a group of structurally related phosphomonoesterases that includes inositol monophosphatases, and phosphoglucomutase. Here we present a brief history of the therapeutic uses of lithium and then focus on GSK-3 as a therapeutic target in diverse diseases, including bipolar disorder, cancer, and coronavirus infections

    Lithium and Therapeutic Targeting of GSK-3

    No full text
    Lithium salts have been in the therapeutic toolbox for better or worse since the 19th century, with purported benefit in gout, hangover, insomnia, and early suggestions that lithium improved psychiatric disorders. However, the remarkable effects of lithium reported by John Cade and subsequently by Mogens Schou revolutionized the treatment of bipolar disorder. The known molecular targets of lithium are surprisingly few and include the signaling kinase glycogen synthase kinase-3 (GSK-3), a group of structurally related phosphomonoesterases that includes inositol monophosphatases, and phosphoglucomutase. Here we present a brief history of the therapeutic uses of lithium and then focus on GSK-3 as a therapeutic target in diverse diseases, including bipolar disorder, cancer, and coronavirus infections

    Caught Looking : Feminism, Pornography and Censorship

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    This collection of essays, written between 1978 and 1986, embodies both anti-censorship activism and a "fluid dialogue between women and sex". Incorporates current and historic pornographic photographs
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