1,884 research outputs found
Diversity in STEMM: Establishing a Business Case
This report sets out the results of research commissioned by the Royal Society as part of their BIS-funded programme entitled ‘Leading the way: increasing diversity in the scientific workforce’. The research explored whether there is a business case for diversity in STEMM occupations (scientific, technical, engineering, mathematical and medical roles) and whether diverse teams are more likely to do ‘good’ science. The research focused on three of the nine protected characteristics in the Equality Act 2010: gender, ethnicity and disability
Solution of the 2-star model of a network
The p-star model or exponential random graph is among the oldest and
best-known of network models. Here we give an analytic solution for the
particular case of the 2-star model, which is one of the most fundamental of
exponential random graphs. We derive expressions for a number of quantities of
interest in the model and show that the degenerate region of the parameter
space observed in computer simulations is a spontaneously symmetry broken phase
separated from the normal phase of the model by a conventional continuous phase
transition.Comment: 5 pages, 3 figure
Critical phenomena in exponential random graphs
The exponential family of random graphs is one of the most promising class of
network models. Dependence between the random edges is defined through certain
finite subgraphs, analogous to the use of potential energy to provide
dependence between particle states in a grand canonical ensemble of statistical
physics. By adjusting the specific values of these subgraph densities, one can
analyze the influence of various local features on the global structure of the
network. Loosely put, a phase transition occurs when a singularity arises in
the limiting free energy density, as it is the generating function for the
limiting expectations of all thermodynamic observables. We derive the full
phase diagram for a large family of 3-parameter exponential random graph models
with attraction and show that they all consist of a first order surface phase
transition bordered by a second order critical curve.Comment: 14 pages, 8 figure
Mid-infrared diagnostics of starburst galaxies: clumpy, dense structures in star-forming regions in the Antennae (NGC 4038/4039)
Recently, mid-infrared instruments have become available on several large
ground-based telescopes, resulting in data sets with unprecedented spatial
resolution at these long wavelengths. In this paper we examine
'ground-based-only' diagnostics, which can be used in the study of star-forming
regions in starburst galaxies. By combining output from the stellar population
synthesis code Starburst 99 with the photoionization code Mappings, we model
stellar clusters and their surrounding interstellar medium, focusing on the
evolution of emission lines in the N- and Q-band atmospheric windows (8-13 and
16.5-24.5 micron respectively) and those in the near-infrared. We address the
detailed sensitivity of various emission line diagnostics to stellar population
age, metallicity, nebular density, and ionization parameter. Using our model
results, we analyze observations of two stellar clusters in the overlap region
of the Antennae galaxies obtained with VLT Imager and Spectrometer for mid
Infrared (VISIR). We find evidence for clumpy, high density, ionized gas. The
two clusters are young (younger than 2.5 and 3 Myr respectively), the
surrounding interstellar matter is dense (10^4 cm^-3 or larger) and can be
characterized by a high ionization parameter (logU > -1.53). Detailed analysis
of the mid-infrared spectral features shows that a (near-)homogeneous medium
cannot account for the observations, and that complex structure on scales below
the resolution limit, containing several young stellar clusters embedded in
clumpy gas, is more likely.Comment: 24 pages, 16 figures (3 in color), accepted for publication in Ap
Extended polarized semiclassical model for quantum-dot cavity QED and its application to single-photon sources
We present a simple extension of the semi-classical model for a two-level
system in a cavity, in order to incorporate multiple polarized transitions,
such as those appearing in neutral and charged quantum dots (QDs), and two
nondegenerate linearly polarized cavity modes. We verify the model by exact
quantum master equation calculations, and experimentally using a neutral QD in
a polarization non-degenerate micro-cavity, in both cases we observe excellent
agreement. Finally, the usefulness of this approach is demonstrated by
optimizing a single-photon source based on polarization postselection, where we
find an increase in the brightness for optimal polarization conditions as
predicted by the model.Comment: 8 pages, for simple code see https://doi.org/10.5281/zenodo.347666
Predicting the likelihood of successful medical treatment of early pregnancy loss:development and internal validation of a clinical prediction model
STUDY QUESTION: What are clinical predictors for successful medical treatment in case of early pregnancy loss (EPL)? SUMMARY ANSWER: Use of mifepristone, BMI, number of previous uterine aspirations and the presence of minor clinical symptoms (slight vaginal bleeding or some abdominal cramps) at treatment start are predictors for successful medical treatment in case of EPL. WHAT IS KNOWN ALREADY: Success rates of medical treatment for EPL vary strongly, between but also within different treatment regimens. Up until now, although some predictors have been identified, no clinical prediction model has been developed yet. STUDY DESIGN, SIZE, DURATION: Secondary analysis of a multicentre randomized controlled trial in 17 Dutch hospitals, executed between 28 June 2018 and 8 January 2020. PARTICIPANTS/MATERIALS, SETTING, METHODS: Women with a non-viable pregnancy between 6 and 14 weeks of gestational age, who opted for medical treatment after a minimum of 1 week of unsuccessful expectant management. Potential predictors for successful medical treatment of EPL were chosen based on literature and expert opinions. We internally validated the prediction model using bootstrapping techniques. MAIN RESULTS AND THE ROLE OF CHANCE: 237 out of 344 women had a successful medical EPL treatment (68.9%). The model includes the following variables: use of mifepristone, BMI, number of previous uterine aspirations and the presence of minor clinical symptoms (slight vaginal bleeding or some abdominal cramps) at treatment start. The model shows a moderate capacity to discriminate between success and failure of treatment, with an AUC of 67.6% (95% CI = 64.9-70.3%). The model had a good fit comparing predicted to observed probabilities of success but might underestimate treatment success in women with a predicted probability of success of ∼70%. LIMITATIONS, REASONS FOR CAUTION: The vast majority (90.4%) of women were Caucasian, potentially leading to less optimal model performance in a non-Caucasian population. Limitations of our model are that we have not yet been able to externally validate its performance and clinical impact, and the moderate accuracy of the prediction model of 0.67. WIDER IMPLICATIONS OF THE FINDINGS: We developed a prediction model, aimed to improve and personalize counselling for medical treatment of EPL by providing a woman with her individual chance of complete evacuation. STUDY FUNDING/COMPETING INTEREST(S): The Triple M Trial, upon which this secondary analysis was performed, was funded by the Healthcare Insurers Innovation Foundation (project number 3080 B15-191). TRIAL REGISTRATION NUMBER: Clinicaltrials.gov: NCT03212352
The structure and function of complex networks
Inspired by empirical studies of networked systems such as the Internet,
social networks, and biological networks, researchers have in recent years
developed a variety of techniques and models to help us understand or predict
the behavior of these systems. Here we review developments in this field,
including such concepts as the small-world effect, degree distributions,
clustering, network correlations, random graph models, models of network growth
and preferential attachment, and dynamical processes taking place on networks.Comment: Review article, 58 pages, 16 figures, 3 tables, 429 references,
published in SIAM Review (2003
Analysis of MHC class I and II expression in relation to presence of HPV genotypes in premalignant and malignant cervical lesions.
Cervical intraepithelial neoplasia (CIN) grades I to III lesions (n = 94) and squamous cell carcinomas of the uterine cervix (n = 27) were analysed for MHC class I and II expression and presence of HPV genotypes. MHC class I and II expression was studied by immunohistochemistry and HPV typing was performed by general primer- and type-specific primer mediated PCR (GP/TS PCR). Both techniques were performed on paraffin embedded tissue sections. Results show disturbed MHC class I heavy chain expression in CIN I to CIN III, as well as in cervical carcinomas. Upregulated MHC class II expression on dysplastic epithelial cells was also found in the different CIN groups and carcinomas. Prevalence of HPV genotypes increased with the severity of the lesion, mainly due to the contribution of the HPV types 16 and 18. No correlation could be established between the presence of specific HPV genotypes and any MHC expression pattern in the different CIN groups or cervical carcinomas. In some cases these data were confirmed by RNA in situ hybridisation showing HPV 16 E7 transcripts in the same dysplastic/neoplastic cells from which MHC status was determined. The results indicate that local differences may exist in the type of cellular immune response to HPV induced lesions
Feed as a vehiculum of salmonella in pigs
Competitive exclusion for the prevention of intestinal colonization by Salmonella is an attractive approach that showed promise in some animal species. Nurmi and Rantala demonstrated that the susceptibility of broiler chicks to colonization by Salmonella spp. was due to the delayed establishment of intestinal microflora in chickens. They also showed that Salmonella spp. infections could be prevented by feeding the chicks with anaerobic cultures of normal adult fowl flora (Nurmi et all973). Although the efficacy of competitive exclusion has been demonstrated in chickens, little work has been done with other species. Mucosal competitive exclusion was recently used to control Salmonella in swine and tends to reduce the presence of Salmonella in tissues (Fedorka-Cray et al, 1996). Other studies have used well characterized lactic acid bacteria. Shanhani et al ( 1977) reported that lactobacilli could inhibit the growth of Salmonella in vitro. Competitive exclusion of E. coli and other pathogens by lactobacilli and their cell wall fragments has been demonstrated on human cells in culture by several other workers (Chan et al 1985, Coconnier et al. 992). The most commonly used and reported probiotics include lactobacilli (L. acidophilus, L. casei, L. bulgaricus), and bifidobacteria (B. bifidum, B.longum, B. breve, B. infantis) (Saavedra J.M. 1995). One of the proposed mode of action of such microbial preparations is that the component organisms may colonize the intestine, inhibit the growth of pathogenic bacteria such as salmonellae, and establish a more favourable environment in the host animal (Jin L.Z. et al1996). Carrier state of Salmonella in swine productions may result in contamination of meat. Efforts are now being made to control Salmonella infection at farm-level and probiotics seems to be a practical and safe approach. The objective of this experiment was to determine if probiotics used as feed additive influence the colonization of tissues and the shedding of Salmonella typhimurium in experimentally infected pigs
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