A Delphi Examination of Public Sector ERP Implementation Issues

A Delphi survey of ERP life cycle management issues was conducted within five agencies of the Queensland government. The five agencies each implemented SAP Financials at around the same time using the services of a common implementation partner. Responses were elicited from ERP project participants, from managers at the agencies, and from users of the financial systems. Valid questionnaires were returned from 61 respondents in the first round survey (response rate = 55%) and yielded 274 perceived issues. Through two rounds of the Delphi survey, these issues have been summarized and categorized into 10 major issue categories (with 38 sub-issues). The final survey round in which respondents will assign weights to these issues is currently underway. Lessons drawn from this study will assist in understanding the ERP life cycle and specific characteristics of the public sector ERP life cycle, and will provide insights into the strengths and weaknesses of ERP systems for public sector organizations

Long range polarization attraction between two different likely charged macroions

It is known that in a water solution with multivalent counterions (Z-ions), two likely charged macroions can attract each other due to correlations of Z-ions adsorbed on their surfaces. This "correlation" attraction is short-ranged and decays exponentially with increasing distance between macroions at characteristic distance A/2\pi, where A is the average distance between Z-ions on the surfaces of macroions. In this work, we show that an additional long range "polarization" attraction exists when the bare surface charge densities of the two macroions have the same sign, but are different in absolute values. The key idea is that with adsorbed Z-ions, two insulating macroions can be considered as conductors with fixed but different electric potentials. Each potential is determined by the difference between the entropic bulk chemical potential of a Z-ion and its correlation chemical potential at the surface of the macroion determined by its bare surface charge density. When the two macroions are close enough, they get polarized in such a way that their adjacent spots form a charged capacitor, which leads to attraction. In a salt free solution this polarization attractive force is long ranged: it decays as a power of the distance between the surfaces of two macroions, d. The polarization force decays slower than the van der Waals attraction and therefore is much larger than it in a large range of distances. In the presence of large amount of monovalent salt, when A/2\pi<< d<< r_s (r_s is the Debye-H\"{u}ckel screening radius), this force is still much stronger than the van der Waals attraction and the correlation attraction mentioned above.Comment: 12 pages, 7 figures. Small change in the text, no change in result

Chondrosarcoma of the Thorax

Although a rare entity, chondrosarcoma is the most common malignant tumor of the chest wall. Most patients present with an enlarging, painful anterior chest wall mass arising from the costochondrosternal junction. CT scan with intravenous contrast is the gold standard radiographic study for diagnosis and operative planning. Contrary to previous dictum, resection may be performed in an appropriate surgical candidate based on imaging characteristics or image-guided percutaneous biopsy results; incisional biopsy is rarely required. The keys to successful treatment are early recognition and radical excision with adequate margins, as chondrosarcoma is relatively resistant to radiotherapy and conventional cytotoxic chemotherapy. Overall survival is excellent in most surgical series from experienced centers. Complete excision with widely negative microscopic margins at the initial operation is of the utmost importance, as local recurrence portends systemic metastasis and eventual tumor-related mortality. This paper summarizes data from relevant surgical series and thereupon draws conclusions regarding preoperative, intraoperative, and postoperative management of thoracic chondrosarcoma

Force on a neutral atom near conducting microstructures

We derive the non-retarded energy shift of a neutral atom for two different geometries. For an atom close to a cylindrical wire we find an integral representation for the energy shift, give asymptotic expressions, and interpolate numerically. For an atom close to a semi-infinite halfplane we determine the exact Green's function of the Laplace equation and use it derive the exact energy shift for an arbitrary position of the atom. These results can be used to estimate the energy shift of an atom close to etched microstructures that protrude from substrates.Comment: 7 pages, 5 figure

Ion exchange phase transitions in "doped" water--filled channels

Ion transport through narrow water--filled channels is impeded by a high electrostatic barrier. The latter originates from the large ratio of the dielectric constants of the water and a surrounding media. We show that ``doping'', i.e. immobile charges attached to the walls of the channel, substantially reduces the barrier. This explains why most of the biological ion channels are ``doped''. We show that at rather generic conditions the channels may undergo ion exchange phase transitions (typically of the first order). Upon such a transition a finite latent concentration of ions may either enter or leave the channel, or be exchanged between the ions of different valences. We discuss possible implications of these transitions for the Ca-vs.-Na selectivity of biological Ca channels. We also show that transport of divalent Ca ions is assisted by their fractionalization into two separate excitations.Comment: 16 pages, 27 figure

Effects of magnetic fields on magnetohydrodynamic cylindrical and spherical Richtmyer-Meshkov instability

The effects of seed magnetic fields on the Richtmyer-Meshkov instability driven by converging cylindrical and spherical implosions in ideal magnetohydrodynamics are investigated. Two different seed field configurations at various strengths are applied over a cylindrical or spherical density interface which has a single-dominant-mode perturbation. The shocks that excite the instability are generated with appropriate Riemann problems in a numerical formulation and the effect of the seed field on the growth rate and symmetry of the perturbations on the density interface is examined. We find reduced perturbation growth for both field configurations and all tested strengths. The extent of growth suppression increases with seed field strength but varies with the angle of the field to interface. The seed field configuration does not significantly affect extent of suppression of the instability, allowing it to be chosen to minimize its effect on implosion distortion. However, stronger seed fields are required in three dimensions to suppress the instability effectively

Electrostatics of Edge States of Quantum Hall Systems with Constrictions: Metal--Insulator Transition Tuned by External Gates

The nature of a metal--insulator transition tuned by external gates in quantum Hall (QH) systems with point constrictions at integer bulk filling, as reported in recent experiments of Roddaro et al. [1], is addressed. We are particularly concerned here with the insulating behavior--the phenomena of backscattering enhancement induced at high gate voltages. Electrostatics calculations for QH systems with split gates performed here show that observations are not a consequence of interedge interactions near the point contact. We attribute the phenomena of backscattering enhancement to a splitting of the integer edge into conducting and insulating stripes, which enable the occurrence of the more relevant backscattering processes of fractionally charged quasiparticles at the point contact. For the values of the parameters used in the experiments we find that the conducting channels are widely separated by the insulating stripes and that their presence alters significantly the low-energy dynamics of the edges. Interchannel impurity scattering does not influence strongly the tunneling exponents as they are found to be irrelevant processes at low energies. Exponents of backscattering at the point contact are unaffected by interchannel Coulomb interactions since all channels have same chirality of propagation.Comment: 19 pages; To appear in Phys. Rev.

Exploring the cytotoxicity, uptake, cellular response, and proteomics of mono- and dinuclear DNA light-switch complexes

Drug resistance to platinum chemotherapeutics targeting DNA often involves abrogation of apoptosis, and has emerged as a significant challenge in modern, non-targeted chemotherapy. Consequently, there is great interest in the anti-cancer properties of metal complexes - particularly those that interact with DNA - and mechanisms of consequent cell death. Herein we compare a parent cytotoxic complex [Ru(phen)2(tpphz)]2+ [phen = 1,10-phenanthroline, tpphz = tetrapyridyl [3,2-a:2',3'-c:3'',2''-h:2''',3'''-j] phenazine], with a mononuclear analogue with modified intercalating ligand, [Ru(phen)2(taptp)]2+,[taptp = 4,5,9,18-tetraazaphenanthreno[9,10-b] triphenylene], and two structurally related di-nuclear, tpphz-bridged, heterometallic complexes, RuRe and RuPt. These changes result in a switch from intercalation to groove binding DNA interaction, concomitant reduction in cytotoxic potency, but no significant change in relative cytotoxicity toward platinum-resistant A2780CIS cancer cells, indicating that DNA interaction mode is not critical for the mechanism of platinum resistance. All variants exhibited a light-switch effect, which for the first time, was exploited to investigate timing of cell death by live cell microscopy. Surprisingly, cell death occurred rapidly as a consequence of oncosis, characterized by loss of cytoplasmic volume control, absence of significant mitochondrial membrane potential loss, and lack of activation of apoptotic cell death markers. Importantly, a novel, quantitative proteomic analysis of the A2780 cell genome following exposure to either mononuclear complex reveals changes in protein expression associated with global cell responses to oxidative stress, and DNA replication/repair cellular pathways. This combination of a multiple targeting modality and induction of a non-apoptotic death mechanism makes these complexes highly promising chemotherapeutic cytotoxicity leads

Gradient of the Casimir force between Au surfaces of a sphere and a plate measured using atomic force microscope in a frequency shift technique

We present measurement results for the gradient of the Casimir force between an Au-coated sphere and an Au-coated plate obtained by means of an atomic force microscope operated in a frequency shift technique. This experiment was performed at a pressure of 3x10^{-8} Torr with hollow glass sphere of 41.3 mcm radius. Special attention is paid to electrostatic calibrations including the problem of electrostatic patches. All calibration parameters are shown to be separation-independent after the corrections for mechanical drift are included. The gradient of the Casimir force was measured in two ways with applied compensating voltage to the plate and with different applied voltages and subsequent subtraction of electric forces. The obtained mean gradients are shown to be in mutual agreement and in agreement with previous experiments performed using a micromachined oscillator. The obtained data are compared with theoretical predictions of the Lifshitz theory including corrections beyond the proximity force approximation. An independent comparison with no fitting parameters demonstrated that the Drude model approach is excluded by the data at a 67% confidence level over the separation region from 235 to 420 nm. The theoretical approach using the generalized plasma-like model is shown to be consistent with the data over the entire measurement range. Corrections due to the nonlinearity of oscillator are calculated and the application region of the linear regime is determined. A conclusion is made that the results of several performed experiments call for a thorough analysis of the basics of the theory of dispersion forces.Comment: 35 pages, 14 figures, 1 table; to appear in Phys. Rev.

The Computation of the Magnetic Field of any Axisymmetric Current Distribution—with Magnetospheric Applications

It is shown that the vector potential A of the magnetic field of any axisymmetric electric current distribution can be expressed in the form ∑ A n (r) P 1 n (cos θ). This series is used to compute the field of two model magnetospheric ring currents; the field of one of these was previously determined by double integrations by Akasofu, Cain & Chapman. The calculation of the functions A n (r) does not require double integrations. The two sets of results are in good agreement. The first term in the series for A gives the external magnetic moment of the ring current. The magnetic field energy is calculated for the field as a whole and for each term in the series for A. The field isointensity lines are drawn, and also the field lines for the ring current and for its field combined with that of the geomagnetic dipole. They illustrate the considerable distortion of the field in the magnetosphere during magnetic storms. The series for A may also be helpful in calculating the paths of cosmic rays in the deformed magnetosphere. The numerical convergence of the results is improved by the use of CesÀro summation.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72484/1/j.1365-246X.1966.tb03088.x.pd