5,770 research outputs found
Scheduling Jobs in Flowshops with the Introduction of Additional Machines in the Future
This is the author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier and can be found at: http://www.journals.elsevier.com/expert-systems-with-applications/.The problem of scheduling jobs to minimize total weighted tardiness in flowshops,\ud
with the possibility of evolving into hybrid flowshops in the future, is investigated in\ud
this paper. As this research is guided by a real problem in industry, the flowshop\ud
considered has considerable flexibility, which stimulated the development of an\ud
innovative methodology for this research. Each stage of the flowshop currently has\ud
one or several identical machines. However, the manufacturing company is planning\ud
to introduce additional machines with different capabilities in different stages in the\ud
near future. Thus, the algorithm proposed and developed for the problem is not only\ud
capable of solving the current flow line configuration but also the potential new\ud
configurations that may result in the future. A meta-heuristic search algorithm based\ud
on Tabu search is developed to solve this NP-hard, industry-guided problem. Six\ud
different initial solution finding mechanisms are proposed. A carefully planned\ud
nested split-plot design is performed to test the significance of different factors and\ud
their impact on the performance of the different algorithms. To the best of our\ud
knowledge, this research is the first of its kind that attempts to solve an industry-guided\ud
problem with the concern for future developments
Diversity of gut microflora is required for the generation of B cell with regulatory properties in a skin graft model
B cells have been reported to promote graft rejection through alloantibody production. However, there is growing evidence that B cells can contribute to the maintenance of tolerance. Here, we used a mouse model of MHC-class I mismatched skin transplantation to investigate the contribution of B cells to graft survival. We demonstrate that adoptive transfer of B cells prolongs skin graft survival but only when the B cells were isolated from mice housed in low sterility "conventional" (CV) facilities and not from mice housed in pathogen free facilities (SPF). However, prolongation of skin graft survival was lost when B cells were isolated from IL-10 deficient mice housed in CV facilities. The suppressive function of B cells isolated from mice housed in CV facilities correlated with an anti-inflammatory environment and with the presence of a different gut microflora compared to mice maintained in SPF facilities. Treatment of mice in the CV facility with antibiotics abrogated the regulatory capacity of B cells. Finally, we identified transitional B cells isolated from CV facilities as possessing the regulatory function. These findings demonstrate that B cells, and in particular transitional B cells, can promote prolongation of graft survival, a function dependent on licensing by gut microflora
Microarray background correction: maximum likelihood estimation for the normal–exponential convolution
Background correction is an important preprocessing step for microarray data that attempts to adjust the data for the ambient intensity surrounding each feature. The “normexp” method models the observed pixel intensities as the sum of 2 random variables, one normally distributed and the other exponentially distributed, representing background noise and signal, respectively. Using a saddle-point approximation, Ritchie and others (2007) found normexp to be the best background correction method for 2-color microarray data. This article develops the normexp method further by improving the estimation of the parameters. A complete mathematical development is given of the normexp model and the associated saddle-point approximation. Some subtle numerical programming issues are solved which caused the original normexp method to fail occasionally when applied to unusual data sets. A practical and reliable algorithm is developed for exact maximum likelihood estimation (MLE) using high-quality optimization software and using the saddle-point estimates as starting values. “MLE” is shown to outperform heuristic estimators proposed by other authors, both in terms of estimation accuracy and in terms of performance on real data. The saddle-point approximation is an adequate replacement in most practical situations. The performance of normexp for assessing differential expression is improved by adding a small offset to the corrected intensities
Nuclear magnetic resonance measurements reveal the origin of the Debye process in monohydroxy alcohols
Monohydroxy alcohols show a structural relaxation and at longer time scales a
Debye-type dielectric peak. From spin-lattice relaxation experiments using
different nuclear probes an intermediate, slower-than-structural dynamics is
identified for n-butanol. Based on these findings and on diffusion
measurements, a model of self-restructuring, transient chains is proposed. The
model is demonstrated to explain consistently the so far puzzling observations
made for this class of hydrogen-bonded glass forming liquids.Comment: 4 pages, 4 figure
Antibiotic pharmacoeconomics: an attempt to find the real cost of hospital antibiotic prescribing.
Antibiotics account for a large part of all hospital pharmacy budgets, but the actual cost of their prescription is unknown. These costs include intravenous administration, labour, serum antibiotic assay, monitoring of haematological and biochemical indices, disposal of sharps and adverse effects. An in-house method of costing antibiotic therapy is presented, to quantify these hidden expenses. Since not only an awareness, but an accurate quantification, of hidden costs is required, a study of various hospital procedures relating directly to antibiotic therapy was undertaken in an acute medical ward; this involved the identification of particular staff members performing various procedures, consumables used and time taken. The cost of five-day courses of gentamicin, penicillin G, ampicillin, flucloxacillin, cefuroxime, ceftotaxime and erythromycin has been calculated; drug and hidden costs for each are presented graphically for comparison. The breakdown cost for gentamicin is presented to illustrate the method. The costing of adverse effects has not been attempted. We suggest that costings of this sort are used in cost-benefit analysis of antibiotic use. These calculations have been incorporated into a computer spreadsheet and this costing service will be offered to clinical areas of our hospital
The Effect of low Momentum Quantum Fluctuations on a Coherent Field Structure
In the present work the evolution of a coherent field structure of the
Sine-Gordon equation under quantum fluctuations is studied. The basic equations
are derived from the coherent state approximation to the functional
Schr\"odinger equation for the field. These equations are solved asymptotically
and numerically for three physical situations. The first is the study of the
nonlinear mechanism responsible for the quantum stability of the soliton in the
presence of low momentum fluctuations. The second considers the scattering of a
wave by the Soliton. Finally the third problem considered is the collision of
Solitons and the stability of a breather.
It is shown that the complete integrability of the Sine-Gordon equation
precludes fusion and splitting processes in this simplified model.
The approximate results obtained are non-perturbative in nature, and are
valid for the full nonlinear interaction in the limit of low momentum
fluctuations. It is also found that these approximate results are in good
agreement with full numerical solutions of the governing equations. This
suggests that a similar approach could be used for the baby Skyrme model, which
is not completely integrable. In this case the higher space dimensionality and
the internal degrees of freedom which prevent the integrability will be
responsable for fusion and splitting processes. This work provides a starting
point in the numerical solution of the full quantum problem of the interaction
of the field with a fluctuation.Comment: 15 pages, 9 (ps) figures, Revtex file. Some discussion expanded but
conclusions unchanged. Final version to appear in PR
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Comparison of free tropospheric western Pacific air mass classification schemes for the PEM-West A experiment
During September/October 1991, NASA's Global Tropospheric Experiment (GTE) conducted an airborne field measurement program (PEM-West A) in the troposphere over the western Pacific Ocean. In this paper we describe and use the relative abundance of the combustion products C2H2 and CO to classify air masses encountered during PEM-West A based on the degree that these tracers were processed by the combined effects of photochemical reactions and dynamical mixing (termed the degree of atmospheric processing). A large number of trace compounds (e.g., C2H6, C3H8, C6H6, NOy, and O3) are found to be well correlated with the degree of atmospheric processing that is reflected by changes in the ratio of C2H2/CO over the range of values from ∼0.3 to 2.0 (parts per trillion volume) C2H2/ (parts per billion volume) CO. This C2H2/CO-based classification scheme is compared to model simulations and to two independent classification schemes based on air mass back-trajectory analyses and lidar profiles of O3 and aerosols. In general, these schemes agree well, and in combination they suggest that the functional dependence that other observed species exhibit with respect to the C2H2/CO atmospheric processing scale can be used to study the origin, sources, and sinks of trace species and to derive several important findings. First, the degree of atmospheric processing is found to be dominated by dilution associated with atmospheric mixing, which is found to primarily occur through the vertical mixing of relatively recent emissions of surface layer trace species. Photochemical reactions play their major role by influencing the background concentrations of trace species that are entrained during the mixing (i.e., dilution) process. Second, a significant noncontinental source(s) of NO (and NOx) in the free troposphere is evident. In particular, the enhanced NO mixing ratios that were observed in convected air masses are attributed to either emissions from lightning or the rapid recycling of NOy compounds. Third, nonsoluble trace species emitted in the continental boundary layer, such as CO and hydrocarbons, are vertically transported to the upper troposphere as efficiently as they are to the midtroposphere. In addition, the mixing ratios of CO and hydrocarbons in the upper troposphere over the western Pacific may reflect a significant contribution from northern hemisphere land areas other than Asia. Finally, we believe that these results can be valuable for the quantitative evaluation of the vertical transport processes that are usually parameterized in models. Copyright 1996 by the American Geophysical Union
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