The effects of pentadecapeptide BPC 157 on the healing of the incisional skin wound in rats

Healing of the wounds is accomplished by: the resolution of vessel constriction, the primary platelet plug formation, the fibrin mesh which acts to stabilize the platelet plug and finally resolution of the clot. By simultaneously curing cutaneous and other tissue wounds (colocutaneous, gastrocutaneous, esophagocutaneous, duodenocutaneous, vesicovaginal, and rectovaginal) in rats, the potency of stable gastric pentadecapeptide BPC 157 (Body Protective Compound 157) has been already proven. We focused on the unexplored therapy effect of BPC 157 on an incisional wound

Potential role of peripheral and central vascular failure in neuroleptic, amphetamine and domperidone pharmacodynamics and toxicolog

Vascular failure is a pathological entity that seems to be antecedent to various pathological processes. This investigation theorized that vascular failure-related phenomena would be apparent in early phases after the application of neuroleptics, amphetamine, and domperidone before their expected behavioral and neurological symptoms. BPC-157 pentadecapeptide (BPC157) showed vascular failure mitigating properties in previous investigations and was used to further elaborate findings

Molecular effects of stable gastric pentadecapeptide BPC 157 on psoriasis

Psoriasis is a chronic, relapsing, immune-mediated skin disease. Etiopathogeniesis of psoriasis includes pro-inflammatory cytokines such as: TNF-alpha, IL-12, IL-17, IL-23 etc. IL-17 exerts its effect by binding to IL-17R (Interleukin-17 receptor) on keratinocytes. Keratinocytes then in response produce β2-defensin. β-defensins have multiple antimicrobial and pro-inflammatory effects that are observed in psoriasis. Since stable gastric pentadecapeptide BPC 157 has shown anti-inflammatory effects in several studies, in this research we explored antiinflammatory effects of BPC 157 on molecular level in psoriasis

New insights in the physiological and pharmacological mechanisms of gastric mucosa protection

Zaštita sluznice želuca još uvijek je relevantno istraživačko pitanje. Značajnost zaštite sluznice želuca polazi iz temeljnih principa teorije stresa. Dva temeljna pristupa u istraživanju su smanjivanje agresivnih čimbenika koji djeluju na sluznicu, poput povišenja pH i eradikacija Hp, te poticanje endogenih zaštitnih mehanizama poput NO, PG, SH i angiogenih faktora rasta. Periferni i centralni mehanizmi djeluju u sinergiji da bi organizam cjelovito održao integritet želučane sluznice. Nove spoznaje ukazuju da je mepiramin učinkovit u zaštiti od iritirajućih agensa kada je primjenjen centralno. Uništavanjem izvora endogenih projekcija dopaminskih neurona moždanog debla prema amigdali pogoršavaju se stresne lezije. Nadalje, zašitita sluznice želuca od ishemijsko reperfuzijske ozljede i prekondicioniranje ovisno je o glukokortikoidima. S obzirom na sve veću rezistenciju bakterija, nove terapijske opcije za Hp su nužne. BQT donosi sve više rezultata učinkovite terapijske opcije. Hspp, često nerazmotreni od strane kliničara, pokazali su ovisnost o pH, gdje je viši pH smanjio njihovu vijabilnost. PD-MSC pokazala je ogroman potencijal u rješavanju problema kroničnog atrofičnog gastritisa. Adenokarcinomi želuca bi se u budućnosti mogli liječiti u jednostavnim oblicima s izocijanatima izolirano ili u kombinaciji sa cisplatinom. Također ivermektin je pokazao potencijal liječenja adenokarcinoma preko WNT/B-cateninskog molekularnog puta. NSAIL-i, u kombinaciji s “plinovitim” medijatorima citoprotekcije, mogli bi uistinu održati funkcionalnost NSAIL-a uz smanjivanje njihovih komplikacija. Na kraju, pentadekapeptid BPC 157 opetovano pokazuje u kliničkim i pretkliničkim studijama djelotvornost u bolestima razne etiopatogeneze, što ide u prilog teoriji da je probavni sustav ipak jedan od temeljnih integratora reakcije protiv ugroze homeostaze.Protection of the gastric mucosa is still a relevant research question. The importance of protecting the stomach mucosa is based on the basic principles of stress theory. The two basic research approaches are the reduction of aggressive factors that act on the mucous membrane, such as an increase in pH and the eradication of Hp, and the stimulation of endogenous protective mechanisms, such as NO, PG, SH, CO and angiogenic growth factors. Peripheral and central mechanisms work in synergy for the organism to maintain the integrity of the gastric mucosa. New insights indicate that mepyramine is effective in protecting against irritating agents when administered centrally. By destroying the source of endogenous projections of brainstem dopamine neurons to the amygdala, stress lesions are exacerbated. Furthermore, protecting the gastric mucosa from ischemia-reperfusion injury and preconditioning is dependent on glucocorticoids. New therapeutic options for Hp are necessary today as increasing bacterial resistance develops. BQT is bringing more and more results as an effective therapeutic option. Hspp, often overlooked by clinicians, have shown pH dependence, where higher pH decreased their viability. PD-MSC has shown great potential in solving the problem of chronic atrophic gastritis. In the future, gastric adenocarcinomas could be treated with isocyanates alone or in combination with other chemotherapeutics. Also, ivermectin has shown the potential to treat adenocarcinoma via the WNT/B-catenin molecular pathway. NSAIDs in combination with "gaseous" mediators of cytoprotection could truly maintain the functionality of NSAIDs while reducing their complications. Pentadecapeptide BPC 157 repeatedly shows in clinical and preclinical studies its effectiveness in diseases of various etiopathogenesis, which supports the theory that the digestive system is one of the fundamental integrators of the reaction against threats to homeostasis

New insights in the physiological and pharmacological mechanisms of gastric mucosa protection

Zaštita sluznice želuca još uvijek je relevantno istraživačko pitanje. Značajnost zaštite sluznice želuca polazi iz temeljnih principa teorije stresa. Dva temeljna pristupa u istraživanju su smanjivanje agresivnih čimbenika koji djeluju na sluznicu, poput povišenja pH i eradikacija Hp, te poticanje endogenih zaštitnih mehanizama poput NO, PG, SH i angiogenih faktora rasta. Periferni i centralni mehanizmi djeluju u sinergiji da bi organizam cjelovito održao integritet želučane sluznice. Nove spoznaje ukazuju da je mepiramin učinkovit u zaštiti od iritirajućih agensa kada je primjenjen centralno. Uništavanjem izvora endogenih projekcija dopaminskih neurona moždanog debla prema amigdali pogoršavaju se stresne lezije. Nadalje, zašitita sluznice želuca od ishemijsko reperfuzijske ozljede i prekondicioniranje ovisno je o glukokortikoidima. S obzirom na sve veću rezistenciju bakterija, nove terapijske opcije za Hp su nužne. BQT donosi sve više rezultata učinkovite terapijske opcije. Hspp, često nerazmotreni od strane kliničara, pokazali su ovisnost o pH, gdje je viši pH smanjio njihovu vijabilnost. PD-MSC pokazala je ogroman potencijal u rješavanju problema kroničnog atrofičnog gastritisa. Adenokarcinomi želuca bi se u budućnosti mogli liječiti u jednostavnim oblicima s izocijanatima izolirano ili u kombinaciji sa cisplatinom. Također ivermektin je pokazao potencijal liječenja adenokarcinoma preko WNT/B-cateninskog molekularnog puta. NSAIL-i, u kombinaciji s “plinovitim” medijatorima citoprotekcije, mogli bi uistinu održati funkcionalnost NSAIL-a uz smanjivanje njihovih komplikacija. Na kraju, pentadekapeptid BPC 157 opetovano pokazuje u kliničkim i pretkliničkim studijama djelotvornost u bolestima razne etiopatogeneze, što ide u prilog teoriji da je probavni sustav ipak jedan od temeljnih integratora reakcije protiv ugroze homeostaze.Protection of the gastric mucosa is still a relevant research question. The importance of protecting the stomach mucosa is based on the basic principles of stress theory. The two basic research approaches are the reduction of aggressive factors that act on the mucous membrane, such as an increase in pH and the eradication of Hp, and the stimulation of endogenous protective mechanisms, such as NO, PG, SH, CO and angiogenic growth factors. Peripheral and central mechanisms work in synergy for the organism to maintain the integrity of the gastric mucosa. New insights indicate that mepyramine is effective in protecting against irritating agents when administered centrally. By destroying the source of endogenous projections of brainstem dopamine neurons to the amygdala, stress lesions are exacerbated. Furthermore, protecting the gastric mucosa from ischemia-reperfusion injury and preconditioning is dependent on glucocorticoids. New therapeutic options for Hp are necessary today as increasing bacterial resistance develops. BQT is bringing more and more results as an effective therapeutic option. Hspp, often overlooked by clinicians, have shown pH dependence, where higher pH decreased their viability. PD-MSC has shown great potential in solving the problem of chronic atrophic gastritis. In the future, gastric adenocarcinomas could be treated with isocyanates alone or in combination with other chemotherapeutics. Also, ivermectin has shown the potential to treat adenocarcinoma via the WNT/B-catenin molecular pathway. NSAIDs in combination with "gaseous" mediators of cytoprotection could truly maintain the functionality of NSAIDs while reducing their complications. Pentadecapeptide BPC 157 repeatedly shows in clinical and preclinical studies its effectiveness in diseases of various etiopathogenesis, which supports the theory that the digestive system is one of the fundamental integrators of the reaction against threats to homeostasis

New insights in the physiological and pharmacological mechanisms of gastric mucosa protection

Zaštita sluznice želuca još uvijek je relevantno istraživačko pitanje. Značajnost zaštite sluznice želuca polazi iz temeljnih principa teorije stresa. Dva temeljna pristupa u istraživanju su smanjivanje agresivnih čimbenika koji djeluju na sluznicu, poput povišenja pH i eradikacija Hp, te poticanje endogenih zaštitnih mehanizama poput NO, PG, SH i angiogenih faktora rasta. Periferni i centralni mehanizmi djeluju u sinergiji da bi organizam cjelovito održao integritet želučane sluznice. Nove spoznaje ukazuju da je mepiramin učinkovit u zaštiti od iritirajućih agensa kada je primjenjen centralno. Uništavanjem izvora endogenih projekcija dopaminskih neurona moždanog debla prema amigdali pogoršavaju se stresne lezije. Nadalje, zašitita sluznice želuca od ishemijsko reperfuzijske ozljede i prekondicioniranje ovisno je o glukokortikoidima. S obzirom na sve veću rezistenciju bakterija, nove terapijske opcije za Hp su nužne. BQT donosi sve više rezultata učinkovite terapijske opcije. Hspp, često nerazmotreni od strane kliničara, pokazali su ovisnost o pH, gdje je viši pH smanjio njihovu vijabilnost. PD-MSC pokazala je ogroman potencijal u rješavanju problema kroničnog atrofičnog gastritisa. Adenokarcinomi želuca bi se u budućnosti mogli liječiti u jednostavnim oblicima s izocijanatima izolirano ili u kombinaciji sa cisplatinom. Također ivermektin je pokazao potencijal liječenja adenokarcinoma preko WNT/B-cateninskog molekularnog puta. NSAIL-i, u kombinaciji s “plinovitim” medijatorima citoprotekcije, mogli bi uistinu održati funkcionalnost NSAIL-a uz smanjivanje njihovih komplikacija. Na kraju, pentadekapeptid BPC 157 opetovano pokazuje u kliničkim i pretkliničkim studijama djelotvornost u bolestima razne etiopatogeneze, što ide u prilog teoriji da je probavni sustav ipak jedan od temeljnih integratora reakcije protiv ugroze homeostaze.Protection of the gastric mucosa is still a relevant research question. The importance of protecting the stomach mucosa is based on the basic principles of stress theory. The two basic research approaches are the reduction of aggressive factors that act on the mucous membrane, such as an increase in pH and the eradication of Hp, and the stimulation of endogenous protective mechanisms, such as NO, PG, SH, CO and angiogenic growth factors. Peripheral and central mechanisms work in synergy for the organism to maintain the integrity of the gastric mucosa. New insights indicate that mepyramine is effective in protecting against irritating agents when administered centrally. By destroying the source of endogenous projections of brainstem dopamine neurons to the amygdala, stress lesions are exacerbated. Furthermore, protecting the gastric mucosa from ischemia-reperfusion injury and preconditioning is dependent on glucocorticoids. New therapeutic options for Hp are necessary today as increasing bacterial resistance develops. BQT is bringing more and more results as an effective therapeutic option. Hspp, often overlooked by clinicians, have shown pH dependence, where higher pH decreased their viability. PD-MSC has shown great potential in solving the problem of chronic atrophic gastritis. In the future, gastric adenocarcinomas could be treated with isocyanates alone or in combination with other chemotherapeutics. Also, ivermectin has shown the potential to treat adenocarcinoma via the WNT/B-catenin molecular pathway. NSAIDs in combination with "gaseous" mediators of cytoprotection could truly maintain the functionality of NSAIDs while reducing their complications. Pentadecapeptide BPC 157 repeatedly shows in clinical and preclinical studies its effectiveness in diseases of various etiopathogenesis, which supports the theory that the digestive system is one of the fundamental integrators of the reaction against threats to homeostasis

Molecular effects of stable gastric pentadecapeptide BPC 157 on psoriasis

Psoriasis is a chronic, relapsing, immune-mediated skin disease. Etiopathogeniesis of psoriasis includes pro-inflammatory cytokines such as: TNF-alpha, IL-12, IL-17, IL-23 etc. IL-17 exerts its effect by binding to IL-17R (Interleukin-17 receptor) on keratinocytes. Keratinocytes then in response produce β2-defensin. β-defensins have multiple antimicrobial and pro-inflammatory effects that are observed in psoriasis. Since stable gastric pentadecapeptide BPC 157 has shown anti-inflammatory effects in several studies, in this research we explored antiinflammatory effects of BPC 157 on molecular level in psoriasis

Potential role of peripheral and central vascular failure in neuroleptic, amphetamine and domperidone pharmacodynamics and toxicolog

Vascular failure is a pathological entity that seems to be antecedent to various pathological processes. This investigation theorized that vascular failure-related phenomena would be apparent in early phases after the application of neuroleptics, amphetamine, and domperidone before their expected behavioral and neurological symptoms. BPC-157 pentadecapeptide (BPC157) showed vascular failure mitigating properties in previous investigations and was used to further elaborate findings