Integration with Ontologies

One of today’s hottest IT topics is integration, as bringing together information from different sources and structures is not completely solved. The approach outlined here wants to illustrate how ontologies [Gr93] could help to support the integration process

Native Diasporas

The arrival of European settlers in the Americas disrupted indigenous lifeways, and the effects of colonialism shattered Native communities. Forced migration and human trafficking created a diaspora of cultures, languages, and people. Gregory D. Smithers and Brooke N. Newman have gathered the work of leading scholars, including Bill Anthes, Duane Champagne, Daniel Cobb, Donald Fixico, and Joy Porter, among others, in examining an expansive range of Native peoples and the extent of their influences through reaggregation. These diverse and wide-ranging essays uncover indigenous understandings of self-identification, community, and culture through the speeches, cultural products, intimate relations, and political and legal practices of Native peoples. Native Diasporas explores how indigenous peoples forged a sense of identity and community amid the changes wrought by European colonialism in the Caribbean, the Pacific Islands, and the mainland Americas from the seventeenth through the twentieth century. Broad in scope and groundbreaking in the topics it explores, this volume presents fresh insights from scholars devoted to understanding Native American identity in meaningful and methodologically innovative ways

Native Diasporas

The arrival of European settlers in the Americas disrupted indigenous lifeways, and the effects of colonialism shattered Native communities. Forced migration and human trafficking created a diaspora of cultures, languages, and people. Gregory D. Smithers and Brooke N. Newman have gathered the work of leading scholars, including Bill Anthes, Duane Champagne, Daniel Cobb, Donald Fixico, and Joy Porter, among others, in examining an expansive range of Native peoples and the extent of their influences through reaggregation. These diverse and wide-ranging essays uncover indigenous understandings of self-identification, community, and culture through the speeches, cultural products, intimate relations, and political and legal practices of Native peoples. Native Diasporas explores how indigenous peoples forged a sense of identity and community amid the changes wrought by European colonialism in the Caribbean, the Pacific Islands, and the mainland Americas from the seventeenth through the twentieth century. Broad in scope and groundbreaking in the topics it explores, this volume presents fresh insights from scholars devoted to understanding Native American identity in meaningful and methodologically innovative ways

Syk tyrosine kinase is critical for B cell antibody responses and memory B cell survival

Signals from the BCR are required for Ag-specific B cell recruitment into the immune response. Binding of Ag to the BCR induces phosphorylation of immune receptor tyrosine-based activation motifs in the cytoplasmic domains of the CD79a and CD79b signaling subunits, which subsequently bind and activate the Syk protein tyrosine kinase. Earlier work with the DT40 chicken B cell leukemia cell line showed that Syk was required to transduce BCR signals to proximal activation events, suggesting that Syk also plays an important role in the activation and differentiation of primary B cells during an immune response. In this study, we show that Syk-deficient primary mouse B cells have a severe defect in BCR-induced activation, proliferation, and survival. Furthermore, we demonstrate that Syk is required for both T-dependent and T-independent Ab responses, and that this requirement is B cell intrinsic. In the absence of Syk, Ag fails to induce differentiation of naive B cells into germinal center B cells and plasma cells. Finally, we show that the survival of existing memory B cells is dependent on Syk. These experiments demonstrate that Syk plays a critical role in multiple aspects of B cell Ab responses

Brd2/4 and Myc regulate alternative cell lineage programmes during early osteoclast differentiation in vitro

Osteoclast (OC) development in response to nuclear factor kappa-Β ligand (RANKL) is critical for bone homeostasis in health and in disease. The early and direct chromatin regulatory changes imparted by the BET chromatin readers Brd2-4 and OC-affiliated transcription factors (TFs) during osteoclastogenesis are not known. Here, we demonstrate that in response to RANKL, early OC development entails regulation of two alternative cell fate transcriptional programmes, OC vs macrophage, with repression of the latter following activation of the former. Both programmes are regulated in a non-redundant manner by increased chromatin binding of Brd2 at promoters and of Brd4 at enhancers/super-enhancers. Myc, the top RANKL-induced TF, regulates OC development in co-operation with Brd2/4 and Max and by establishing negative and positive regulatory loops with other lineage-affiliated TFs. These insights into the transcriptional regulation of osteoclastogenesis suggest the clinical potential of selective targeting of Brd2/4 to abrogate pathological OC activation

Improving Teacher Recruitment and Retention: The Importance of workload and Pupil Behaviour

The shortage of teachers in England and Wales continues to be a high profile area of scrutiny. Particular subjects (including mathematics; science and English) are categorized by the Training and Development Agency (TDA)for schools as priority or shortage subjects, and London especially has experienced particular shortages in teacher numbers over recent years

Common data elements to standardize genomics studies in cerebral palsy

Aim To define clinical common data elements (CDEs) and a mandatory minimum data set (MDS) for genomic studies of cerebral palsy (CP). Method Candidate data elements were collated following a review of the literature and existing CDEs. An online, three-round Delphi survey was used to rate each data element as either ‘core’, ‘recommended’, ‘exploratory’, or ‘not required’. Members of the International Cerebral Palsy Genomics Consortium (ICPGC) rated the core CDEs as either mandatory or not, to form the MDS. For both the CDEs and the MDS, a data element was considered to have reached consensus if more than 75% of respondents agreed. Results Forty-six individuals from around the world formed the Delphi panel: consumers (n=2), scientists/researchers (n=17), medical (n=19), and allied health professionals (n=8). The CDEs include 107 data elements across six categories: demographics, diagnostics, family history, antenatal and neonatal details, clinical traits, and CP-specific assessments. Of these, 10 are mandatory, 42 core, 41 recommended, and 14 are exploratory. Interpretation The ICPGC CDEs provide a foundation for the standardization of phenotype data captured in CP genomic studies and will benefit international collaborations and pooling of data, particularly in rare conditions

Education Can Compensate for Society - a Bit

In this paper I reflect on the findings of a number of loosely related research projects undertaken with colleagues over the last ten years. Their common theme is equity, in formal education and beyond, in wider family and social settings, and with inequity expressed as the stratification of a variety of educational outcomes. The projects are based on a standard mixture of pre-existing records, official documents, large-scale surveys, observations, interviews and focus groups. The numeric data were largely used to create biographical models of educational experiences, and the in-depth data were used to try to explain individual decisions and disparities at each stage of the model. Data have been collected for England and Wales, in five other countries of the European Union and for Japan. A meta-view of these various findings suggests that national school intakes tend to be at least moderately segregated by prior attainment and socio-economic factors, and that learning outcomes as assessed by formal means, such as examinations, are heavily stratified by these same factors. There is no convincing evidence that compulsory schooling does very much to overcome the initial disparity in the resources and attainment of school intakes. On the other hand, there are indications that the nature of a national school system and the social experiences of young people in schools can begin to equalise educational outcomes as more widely envisaged, including learning to trust and willingness to help others, aspirations, and attitudes to continuing in education and training. The cost-free implications of the argument in this paper, if accepted, are that everything possible should be done to make school intakes comprehensive, and that explicit consideration, by teachers and leaders, of the applied principles of equity could reduce potentially harmful misunderstandings in educational contexts