32,888 research outputs found

    A new quaternary phase observed in a laser treated Zn-Al-Mg-Si coating

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    The microstructure of laser resurfaced Zn-55Al-2Mg-1.5Si coating produced on a hot-dip simulator was characterised by transmission electron microscopy. A new quaternary phase was observed and its crystal structure was determined by electron diffraction

    Deletion within the Src homology domain 3 of Bruton's tyrosine kinase resulting in X-linked agammaglobulinemia (XLA).

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    The gene responsible for X-linked agammaglobulinemia (XLA) has been recently identified to code for a cytoplasmic tyrosine kinase (Bruton's agammaglobulinemia tyrosine kinase, BTK), required for normal B cell development. BTK, like many other cytoplasmic tyrosine kinases, contains Src homology domains (SH2 and SH3), and catalytic kinase domain. SH3 domains are important for the targeting of signaling molecules to specific subcellular locations. We have identified a family with XLA whose affected members have a point mutation (g-->a) at the 5' splice site of intron 8, resulting in the skipping of coding exon 8 and loss of 21 amino acids forming the COOH-terminal portion of the BTK SH3 domain. The study of three generations within this kinship, using restriction fragment length polymorphism and DNA analysis, allowed identification of the mutant X chromosome responsible for XLA and the carrier status in this family. BTK mRNA was present in normal amounts in Epstein-Barr virus-induced B lymphoblastoid cell lines established from affected family members. Although the SH3 deletion did not alter BTK protein stability and kinase activity of the truncated BTK protein was normal, the affected patients nevertheless have a severe B cell defect characteristic for XLA. The mutant protein was modeled using the normal BTK SH3 domain. The deletion results in loss of two COOH-terminal beta strands containing several residues critical for the formation of the putative SH3 ligand-binding pocket. We predict that, as a result, one or more crucial SH3 binding proteins fail to interact with BTK, interrupting the cytoplasmic signal transduction process required for B cell differentiation

    The Development of the WISE (Writing to Inspire Successful Education) Writing Mentoring Program: A University-School Collaboration

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    Abstract This paper describes the development of a service learning writing mentoring program designed to close the achievement gap in writing proficiency for economically disadvantaged seventh grade students. Compared to writing mentoring studies found in the published literature, this program has three distinguishing components. First, it focused on economically disadvantaged middle school students. Second, it provided writing mentoring through a university-school partnership in which college students provided the intervention in collaboration with a seventh-grade teacher. Third, the program used technology to facilitate the mentoring process. Over the course of an academic year, mentors created videos with feedback on 19 writing assignments. The writing mentoring program was associated with a four-fold increase in the percentage of students who were graded as ‘proficient’ on a state standardized writing exam. These results suggest that semi-virtual, intensive writing mentoring and individualized feedback from college students can close the achievement gap and improve the quality of middle level education provided to economically disadvantaged students

    A note on cluster methods for strongly correlated electron systems

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    We develop, clarify and test various aspects of cluster methods dynamical mean field methods using a soluble toy model as a benchmark. We find that the Cellular Dynamical Mean Field Theory (C-DMFT) converges very rapidly and compare its convergence properties with those of the Dynamical Cluster Approximation (DCA). We propose and test improved estimators for the lattice self energy within C-DMFT.Comment: 5 pages, 3 figures; major change

    Global Phase Diagram of the Kondo Lattice: From Heavy Fermion Metals to Kondo Insulators

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    We discuss the general theoretical arguments advanced earlier for the T=0 global phase diagram of antiferromagnetic Kondo lattice systems, distinguishing between the established and the conjectured. In addition to the well-known phase of a paramagnetic metal with a "large" Fermi surface (P_L), there is also an antiferromagnetic phase with a "small" Fermi surface (AF_S). We provide the details of the derivation of a quantum non-linear sigma-model (QNLsM) representation of the Kondo lattice Hamiltonian, which leads to an effective field theory containing both low-energy fermions in the vicinity of a Fermi surface and low-energy bosons near zero momentum. An asymptotically exact analysis of this effective field theory is made possible through the development of a renormalization group procedure for mixed fermion-boson systems. Considerations on how to connect the AF_S and P_L phases lead to a global phase diagram, which not only puts into perspective the theory of local quantum criticality for antiferromagnetic heavy fermion metals, but also provides the basis to understand the surprising recent experiments in chemically-doped as well as pressurized YbRh2Si2. We point out that the AF_S phase still occurs for the case of an equal number of spin-1/2 local moments and conduction electrons. This observation raises the prospect for a global phase diagram of heavy fermion systems in the Kondo-insulator regime. Finally, we discuss the connection between the Kondo breakdown physics discussed here for the Kondo lattice systems and the non-Fermi liquid behavior recently studied from a holographic perspective.Comment: (v3) leftover typos corrected. (v2) Published version. 32 pages, 4 figures. Section 7, on the connection between the Kondo lattice systems and the holographic models of non-Fermi liquid, is expanded. (v1) special issue of JLTP on quantum criticalit

    Effect of Background Evolution on the Curvaton Non-Gaussianity

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    We investigate how the background evolution affects the curvature perturbations generated by the curvaton, assuming a curvaton potential that may deviate slightly from the quadratic one, and parameterizing the background fluid density as \rho\propto a^{-\alpha}, where a is the scale factor, and \alpha depends on the background fluid. It turns out that the more there is deviation from the quadratic case, the more pronounced is the dependence of the curvature perturbation on \alpha. We also show that the background can have a significant effect on the nonlinearity parameters f_NL and g_NL. As an example, if at the onset of the curvaton oscillation there is a dimension 6 contribution to the potential at 5 % level and the energy fraction of the curvaton to the total one at the time of its decay is at 1 %, we find variations \Delta f_NL \sim \mathcal{O}(10) and \Delta g_NL \sim \mathcal{O}(10^4) between matter and radiation dominated backgrounds. Moreover, we demonstrate that there is a relation between f_NL and g_NL that can be used to probe the form of the curvaton potential and the equation of state of the background fluid.Comment: 14 pages, 8 figure
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