3,432 research outputs found
TRADITION, CULTURE, AND THE PROBLEM OF INCLUSION IN PHILOSOPHY
Many today agree that philosophy, as an academic discipline, must, for the sake of its very survival, become more inclusive of a wider range of perspectives, coming from a more diverse pool of philosophers. Yet there has been little serious reflection on how our very idea of what philosophy is might be preventing this change from taking place. In this essay I would like to consider the ways in which our ideas about philosophy\u27s relation to tradition, and its relation to other dimensions of human culture, influence efforts to promote greater diversity in the field
Press One for Warrant: Reinventing the Fourth Amendment\u27s Search Warrant Requirement Through Electronic Procedures
Numerous rulings by the Supreme Court have confirmed the long-held assertion that the Fourth Amendment\u27s warrant requirement is a centerpiece for the law of search and seizure, and that prescreening by neutral and detached magistrates is [at] the heart of citizens\u27 protection against police overreaching. On September 21, 1994, however, these assertions proved inaccurate and painfully hollow for Betty Ingram, a fifty-three-year-old diabetic who awoke to the sound of armed police officers charging through her front door. The officers, who were searching for a suspect involved in a buy- and-bust operation, had neither obtained a search warrant nor knocked and announced their presence. Mistaking Ingram\u27s son for the suspect, they proceeded to handcuff and place him on the floor while pointing their guns at his head. When Ingram\u27s daughter asked what was happening, the officers told her to shut up, lacing their language with expletives. Ingram was hit in the face and knocked down, then handcuffed and shaken so violently that her head struck the couch repeatedly.
Given the Fourth Amendment\u27s general prohibition on unreasonable searches and seizures, and its associated requirement that no Warrants shall issue, but upon probable cause, one might wonder how Ingram found herself in such appalling circumstances. Under what authority did the police forcefully, and perhaps wrongfully, intrude into the home of an innocent citizen? The answer lies in a subtle jurisprudential shift away from the Fourth Amendment\u27s warrant requirement that transpired during the latter part of the twentieth century. Over several decades, the Supreme Court has routinely narrowed the range of cases to which the warrant requirement applies so that, in practice, warrants have become an exception rather than the rule. One scholar catalogued almost twenty such exemptions as of 1985, including searches incident to arrest, automobile searches, border searches, administrative searches of regulated businesses, exigent circumstances, searches incident to nonarrest when there is probable cause to arrest, boat boarding for document checks, welfare searches, inventory searches, airport searches, school searches, searches of government employees\u27 offices, and mobile home searches
La génération spontanée et le problème de la reproduction des espèces avant et après Descartes
Dans cet article je mets en évidence quelques problèmes conceptuels importants posés par le prétendu phénomène de la génération spontanée, en montrant comment ils étaient liés historiquement à la question théorique des origines et de l’ontologie des espèces biologiques. Au XVIe et XVIIe siècle tout particulièrement, la possibilité que des formes organiques soient générées dans la matière inorganique supposait la possibilité que le hasard gouverne non seulement l’apparition d’une anguille ou d’une souris, mais qu’il gouverne l’apparition originelle de leurs espèces mêmes. En outre, dans la conception de la reproduction sexuelle que le mécanisme parvient à répandre, toute génération, des êtres humains aussi bien que des anguilles, menace de ne plus s’expliquer autrement que par ce que Descartes appelle « les causes mineures ». Ainsi, comme je tenterai de le prouver, les problèmes théoriques que la génération spontanée, telle que le début de la modernité la concevait, posaient à la compréhension de l’ontologie des espèces, n’étaient pas essentiellement différents de ceux soulevés par l’explication mécaniste de la reproduction sexuelle, et si nous n’accordons pas à ce fait l’attention nécessaire, nous perdons de vue, je pense, un facteur important dans le rejet ultime de la génération spontanée.In this article I shall draw out some of the important conceptual problems posed by the purported phenomenon of spontaneous generation, showing how these problems were historically connected with the theoretical question of the origins and nature of biological species, and above all with the problem of their boundaries. In the 16th- and 17th- centuries in particular, the possibility of organic forms arising from inorganic matter carried with it the possibility that chance governs not only the emergence of an individual eel or mouse, but indeed governs the original emergence of the mouse- and eel-kinds. Moreover, on the newly ascendant mechanist understanding of sexual reproduction, all generation, whether of eels or of horses and men, now threatened to be exhaustively accounted for in terms of what Descartes called ‘minor causes’. Thus, I argue, the sort of problems that spontaneous generation was perceived to bring about for the early modern understanding of the ontology of species were not in principle any different from the problems posed by the mechanist account of sexual reproduction, and if we fail to note this, I show, we overlook an important factor in the eventual demise of spontaneous-generation theory
Consumer Protection—Exploring Private Causes of Action for Victims of Data Breaches
Data breaches are becoming a norm in modern life. Every year it seems that bigger and bigger attacks are launched, and more and more individuals are harmed. The law has responded by increasing states’ ability to prosecute cybercriminals. A glaring hole exists in this protection though. The state is largely an unharmed party. The real harm is done to individual citizens affected by the breaches. Their data is compromised, their identities are stolen, and their livelihoods are placed at risk. This Article will analyze the issue and propose a solution for increased consumer protection in addition to the current criminal punishments
CONSUMER PROTECTION—EXPLORING PRIVATE CAUSES OF ACTION FOR VICTIMS OF DATA BREACHES
Data breaches are becoming a norm in modern life. Every year it seems that bigger and bigger attacks are launched, and more and more individuals are harmed. The law has responded by increasing states’ ability to prosecute cybercriminals. A glaring hole exists in this protection though. The state is largely an unharmed party. The real harm is done to individual citizens affected by the breaches. Their data is compromised, their identities are stolen, and their livelihoods are placed at risk. This Article will analyze the issue and propose a solution for increased consumer protection in addition to the current criminal punishments
Nuance and behavioral cogency: How the Visible Burrow System inspired the Stress-Alternatives Model and conceptualization of the continuum of anxiety
By creating the Visible Burrow System (VBS) Bob Blanchard found a way to study the interaction of genetics, physiology, environment, and adaptive significance in a model with broad validity. The VBS changed the way we think about anxiety and affective disorders by allowing the mechanisms which control them to be observed in a dynamic setting. Critically, Blanchard used the VBS and other models to show how behavioral systems like defense are dependent upon context and behavioral elements unique to the individual. Inspired by the VBS, we developed a Stress Alternatives Model (SAM) to further explore the multifaceted dynamics of the stress response with a dichotomous choice condition. Like the VBS, the SAM is a naturalistic model built upon risk assessment and defensive behavior, but with a choice of response: escape or submission to a large conspecific aggressor. The anxiety of novelty during the first escape must be weighed against fear of the aggressor, and a decision must be made. Both outcomes are adaptively significant, evidenced by a 50/50 split in outcome across several study systems. By manipulating the variables of the SAM, we show that a gradient of anxiety exists that spans the contextual settings of escaping an open field, escaping from aggression, and submitting to aggression. These findings correspond with increasing levels of corticosterone and increasing levels of NPS and BDNF in the central amygdala as the context changes.Whereas some anxiolytics were able to reduce the latency to escape for some animals, only with the potent anxiolytic drug antalarmin (CRF1R-blocker) and the anxiogenic drug yohimbine (α2 antagonist) were we able to reverse the outcome for a substantial proportion of individuals. Our findings promote a novel method for modeling anxiety, offering a distinction between low-and-high levels, and accounting for individual variability. The translational value of the VBS is immeasurable, and it guided us and many other researchers to seek potential clinical solutions through a deeper understanding of regional neurochemistry and gene expression in concert with an ecological behavioral model
Susceptibility Provision Enhances Effective De-escalation (SPEED): utilizing rapid phenotypic susceptibility testing in Gram-negative bloodstream infections and its potential clinical impact
Abstract
Objectives
We evaluated the performance and time to result for pathogen identification (ID) and antimicrobial susceptibility testing (AST) of the Accelerate Phenoâ„¢ system (AXDX) compared with standard of care (SOC) methods. We also assessed the hypothetical improvement in antibiotic utilization if AXDX had been implemented.
Methods
Clinical samples from patients with monomicrobial Gram-negative bacteraemia were tested and compared between AXDX and the SOC methods of the VERIGENE® and Bruker MALDI Biotyper® systems for ID and the VITEK® 2 system for AST. Additionally, charts were reviewed to calculate theoretical times to antibiotic de-escalation, escalation and active and optimal therapy
Results
ID mean time was 21 h for MALDI-TOF MS, 4.4 h for VERIGENE® and 3.7 h for AXDX. AST mean time was 35 h for VITEK® 2 and 9.0 h for AXDX. For ID, positive percentage agreement was 95.9% and negative percentage agreement was 99.9%. For AST, essential agreement was 94.5% and categorical agreement was 93.5%. If AXDX results had been available to inform patient care, 25% of patients could have been put on active therapy sooner, while 78% of patients who had therapy optimized during hospitalization could have had therapy optimized sooner. Additionally, AXDX could have reduced time to de-escalation (16 versus 31 h) and escalation (19 versus 31 h) compared with SOC.
Conclusions
By providing fast and reliable ID and AST results, AXDX has the potential to improve antimicrobial utilization and enhance antimicrobial stewardship
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