Keck Planet Finder: preliminary design

The Keck Planet Finder (KPF) is a fiber-fed, high-resolution, high-stability spectrometer in development for the W.M. Keck Observatory. The instrument recently passed its preliminary design review and is currently in the detailed design phase. KPF is designed to characterize exoplanets using Doppler spectroscopy with a single measurement precision of 0.5 m s^(−1) or better; however, its resolution and stability will enable a wide variety of other astrophysical pursuits. KPF will have a 200 mm collimated beam diameter and a resolving power greater than 80,000. The design includes a green channel (445 nm to 600 nm) and red channel (600 nm to 870 nm). A novel design aspect of KPF is the use of a Zerodur optical bench, and Zerodur optics with integral mounts, to provide stability against thermal expansion and contraction effects

Spectroelectrochemical responses of thin-film conducting copolymers prepared electrochemically from mixtures of 3,4- ethylenedioxythiophene and 2,2’-bithiophene

Here we have studied the electrocopolymerisation of binary mixtures of functionalised thiophenes in varying compositions and determined independently for each copolymer the 15 spectroelectrochemical responses and the composition of the material using x-ray photoelectron spectroscopy. We have observed strong correlations between the composition of the copolymer material and the composition of the binary solution from which the polymer was grown. In addition, we have shown that the spectroelectrochemical properties of the copolymers indicate the presence of random copolymer material where the λMax values of the neutral, undoped, polymer 20 scales with composition but also suggest that there may be small amounts of block copolymer or phase-separated mixtures of the homopolymer components

A new potential for radiation studies of borosilicate glass

Borosilicate glass containing 70 mol% SiO2 and 30 mol% B2O3 is investigated theoretically using fixed charge potentials. An existing potential parameterisation for borosilicate glass is found to give good agreement for the bond angle and bond length distributions compared to experimental values but the optimal density is 30% higher than experiment. Therefore the potential parameters are refitted to give an optimal density of 2.1 g=cm3, in line with experiment. To determine the optimal density, a series of random initial structures are quenched at a rate of 5 1012 K/s using constant volume molecular dynamics. An average of 10 such quenches is carried out for each fixed volume. For each quenched structure, the bond angles, bond lengths, mechanical properties and melting points are determined. The new parameterisation is found to give the density, bond angles, bond lengths and Young’s modulus comparable with experimental data, however, the melting points and Poisson’s ratio are higher than the reported experimental values. The displacement energy thresholds are computed to be similar to those determined with the earlier parameterisation, which is lower than those for ionic crystalline materials

Report of the panel on geopotential fields: Gravity field, section 8

The objective of the Geopotential Panel was to develop a program of data acquisition and model development for the Earth's gravity and magnetic fields that meet the basic science requirements of the solid Earth and ocean studies. Presented here are the requirements for gravity information and models through the end of the century, the present status of our knowledge, data acquisition techniques, and an outline of a program to meet the requirements

Relaxin family peptide receptors in GtoPdb v.2023.1

Relaxin family peptide receptors (RXFP, nomenclature as agreed by the NC-IUPHAR Subcommittee on Relaxin family peptide receptors [23, 119]) may be divided into two pairs, RXFP1/2 and RXFP3/4. Endogenous agonists at these receptors are heterodimeric peptide hormones structurally related to insulin: relaxin-1, relaxin, relaxin-3 (also known as INSL7), insulin-like peptide 3 (INSL3) and INSL5. Species homologues of relaxin have distinct pharmacology and relaxin interacts with RXFP1, RXFP2 and RXFP3, whereas mouse and rat relaxin selectively bind to and activate RXFP1 [260]. relaxin-3 is the ligand for RXFP3 but it also binds to RXFP1 and RXFP4 and has differential affinity for RXFP2 between species [259]. INSL5 is the ligand for RXFP4 but is a weak antagonist of RXFP3. relaxin and INSL3 have multiple complex binding interactions with RXFP1 [267] and RXFP2 [132] which direct the N-terminal LDLa modules of the receptors together with a linker domain to act as a tethered ligand to direct receptor signaling [262]. INSL5 and relaxin-3 interact with their receptors using distinct residues in their B-chains for binding, and activation, respectively [321, 152]

Evidence that Fetal Death is Associated with Placental Aging

Background: The risk of unexplained fetal death or stillbirth increases late in pregnancy, suggesting that placental aging is an etiological factor. Aging is associated with oxidative damage to DNA, RNA, and lipids. We hypothesized that placentas at >41 completed weeks of gestation (late-term) would show changes consistent with aging that would also be present in placentas associated with stillbirths. Objective: We sought to determine whether placentas from late-term pregnancies and unexplained stillbirth show oxidative damage and other biochemical signs of aging. We also aimed to develop an in vitro term placental explant culture model to test the aging pathways. Study Design: We collected placentas from women at 37-39 weeks’ gestation (early-term and term), late-term, and with unexplained stillbirth. We used immunohistochemistry to compare the 3 groups for: DNA/RNA oxidation (8-hydroxy-deoxyguanosine), lysosomal distribution (lysosome-associated membrane protein 2), lipid oxidation (4-hydroxynonenal), and autophagosome size (microtubule-associated proteins 1A/1B light chain 3B, LC3B). The expression of aldehyde oxidase 1 was measured by real-time polymerase chain reaction. Using a placental explant culture model, we tested the hypothesis that aldehyde oxidase 1 mediates oxidative damage to lipids in the placenta. Results: Placentas from late-term pregnancies show increased aldehyde oxidase 1 expression, oxidation of DNA/RNA and lipid, perinuclear location of lysosomes, and larger autophagosomes compared to placentas from women delivered at 37-39 weeks. Stillbirth-associated placentas showed similar changes in oxidation of DNA/RNA and lipid, lysosomal location, and autophagosome size to placentas from late-term. Placental explants from term deliveries cultured in serum-free medium also showed evidence of oxidation of lipid, perinuclear lysosomes, and larger autophagosomes, changes that were blocked by the G-protein-coupled estrogen receptor 1 agonist G1, while the oxidation of lipid was blocked by the aldehyde oxidase 1 inhibitor raloxifene. Conclusion: Our data are consistent with a role for aldehyde oxidase 1 and G-protein-coupled estrogen receptor 1 in mediating aging of the placenta that may contribute to stillbirth. The placenta is a tractable model of aging in human tissue

Keck Planet Finder: preliminary design

The Keck Planet Finder (KPF) is a fiber-fed, high-resolution, high-stability spectrometer in development for the W.M. Keck Observatory. The instrument recently passed its preliminary design review and is currently in the detailed design phase. KPF is designed to characterize exoplanets using Doppler spectroscopy with a single measurement precision of 0.5 m s^(−1) or better; however, its resolution and stability will enable a wide variety of other astrophysical pursuits. KPF will have a 200 mm collimated beam diameter and a resolving power greater than 80,000. The design includes a green channel (445 nm to 600 nm) and red channel (600 nm to 870 nm). A novel design aspect of KPF is the use of a Zerodur optical bench, and Zerodur optics with integral mounts, to provide stability against thermal expansion and contraction effects

Managing pest species under climate change: risks and opportunities

Human activity is driving significant changes in global and regional climate systems through the enhanced greenhouse effect (IPCC 2007). Global climate models predict that this anthropogenic forcing will alter both mean climate parameters and the frequency and magnitude of extreme meteorological events (e.g. heat waves, severe storm events and droughts). Such changes may have significant destabilizing effects, decoupling existing relationships between species, altering species distributions and challenging current management regimes. However, they may also provide significant management opportunities. Many pest species are expected to expand their geographical range in a warmer, more extreme, climate. Despite this, there is likely to be great variation both in pest species responses to changing climatic conditions and impacts on ecological and production systems, and in the effectiveness of current pest management strategies. This implies a need for ongoing monitoring and assessment of pest species responses to environmental change and management at local and regional scales. It also indicates a need for research aimed at identifying potential tipping points (or critical thresholds) in relation to significant meteorological events. This presentation will focus on the role of risk assessment in decision-making for pest species management under uncertainty. Probabilistic modelling approaches, such as Bayesian Belief networks, provide a valuable adjunct to monitoring and evaluation programs. They facilitate the synthesis of current knowledge (including expert opinion), highlight critical knowledge gaps, and provide a basis for both targeted research and adaptive management. Integrated modelling to predict invasive species response to management under variable climatic conditions can be used to identify key opportunities for management which will contribute disproportionately to effective pest species control. Pest species management programs under future climatic regimes are likely to require the capacity for more adaptive and strategic response, and will need to be supported by flexible investment strategies which enable timely (adaptive) responses at critical periods

High Density Circumstellar Interaction in the Luminous Type IIn SN 2010jl: The first 1100 days

HST and ground based observations of the Type IIn SN 2010jl are analyzed, including photometry, spectroscopy in the ultraviolet, optical and NIR bands, 26-1128 days after first detection. At maximum the bolometric luminosity was $\sim 3\times10^{43}$ erg/s and even at 850 days exceeds $10^{42}$ erg/s. A NIR excess, dominating after 400 days, probably originates in dust in the circumstellar medium (CSM). The total radiated energy is $> 6.5\times10^{50}$ ergs, excluding the dust component. The spectral lines can be separated into one broad component due to electron scattering, and one narrow with expansion velocity $\sim 100$ km/s from the CSM. The broad component is initially symmetric around zero velocity but becomes blueshifted after $\sim 50$ days, while remaining symmetric about a shifted centroid velocity. Dust absorption in the ejecta is unlikely to explain the line shifts, and we attribute the shift instead to acceleration by the SN radiation. From the optical lines and the X-ray and dust properties, there is strong evidence for large scale asymmetries in the CSM. The ultraviolet lines indicate CNO processing in the progenitor, while the optical shows a number of narrow coronal lines excited by the X-rays. The bolometric light curve is consistent with a radiative shock in an $r^{-2}$ CSM with a mass loss rate of $\sim 0.1$ M_sun/yr. The total mass lost is $> 3$ M_sun. These properties are consistent with the SN expanding into a CSM characteristic of an LBV progenitor with a bipolar geometry. The apparent absence of nuclear processing is attributed to a CSM still opaque to electron scattering.Comment: ApJ in press. Updated and changed after referees comment

Electrostatically Directed Self-Assembly of Ultrathin Supramolecular Polymer Microcapsules.

Supramolecular self-assembly offers routes to challenging architectures on the molecular and macroscopic scale. Coupled with microfluidics it has been used to make microcapsules-where a 2D sheet is shaped in 3D, encapsulating the volume within. In this paper, a versatile methodology to direct the accumulation of capsule-forming components to the droplet interface using electrostatic interactions is described. In this approach, charged copolymers are selectively partitioned to the microdroplet interface by a complementary charged surfactant for subsequent supramolecular cross-linking via cucurbit[8]uril. This dynamic assembly process is employed to selectively form both hollow, ultrathin microcapsules and solid microparticles from a single solution. The ability to dictate the distribution of a mixture of charged copolymers within the microdroplet, as demonstrated by the single-step fabrication of distinct core-shell microcapsules, gives access to a new generation of innovative self-assembled constructs.This work was supported by the Engineering Physical Sciences Research Council, Institutional Sponsorship 2012-University of Cambridge EP/K503496/1, and the Translational Grant EP/H046593/1; Y.Z. and R.P. were also funded from the Starting Investigator grant ASPiRe (No. 240629) from the European Research Council and the Isaac Newton Trust research grant No. 13.7(c). A.S. was supported by the Nano Doctoral Training Centre (NanoDTC).This is the final version of the article. It first appeared from Wiley at http://dx.doi.org/10.1002/adfm.20150107