The search for novel analgesics: re-examining spinal cord circuits with new tools

In this perspective, we propose the absence of detailed information regarding spinal cord circuits that process sensory information remains a major barrier to advancing analgesia. We highlight recent advances showing that functionally discrete populations of neurons in the spinal cord dorsal horn play distinct roles in processing sensory information. We then discuss new molecular, electrophysiological, and optogenetic techniques that can be employed to understand how dorsal horn circuits process tactile and nociceptive information. We believe this information can drive the development of entirely new classes of pharmacotherapies that target key elements in spinal circuits to selectively modify sensory function and blunt pain

Micro-CT Characterization of Human Trabecular Bone in Osteogenesis Imperfecta

Osteogenesis imperfecta (OI) is a genetic syndrome affecting collagen synthesis and assembly. Its symptoms vary widely but commonly include bone fragility, reduced stature, and bone deformity. Because of the small size and paucity of human specimens, there is a lack of biomechanical data for OI bone. Most literature has focused on histomorphometric analyses, which rely on assumptions to extrapolate 3-D properties. In this study, a micro-computed tomography (μCT) system was used to directly measure structural and mineral properties in pediatric OI bone collected during routine surgical procedures. Surface renderings suggested a poorly organized, plate-like orientation. Patients with a history of bone-augmenting drugs exhibited increased bone volume fraction (BV/TV), trabecular number (Tb.N), and connectivity density (Eu.Conn.D). The latter two parameters appeared to be related to OI severity. Structural results were consistently higher than those reported in a previous histomorphometric study, but these differences can be attributed to factors such as specimen collection site, drug therapy, and assumptions associated with histomorphometry. Mineral testing revealed strong correlations with several structural parameters, highlighting the importance of a dual approach in trabecular bone testing. This study reports some of the first quantitative μCT data of human OI bone, and it suggests compelling possibilities for the future of OI bone assessment

Decay estimates for variable coefficient wave equations in exterior domains

In this article we consider variable coefficient, time dependent wave equations in exterior domains. We prove localized energy estimates if the domain is star-shaped and global in time Strichartz estimates if the domain is strictly convex.Comment: 15 pages. In the new version, some typos are fixed and a minor correction was made to the proof of Lemma 1

The Environmental Condition of Tan Brook and Campus Pond, A Community and University Concern

Small streams have the unfortunate ability to be greatly impacted by human intervention. Civilizations for centuries have attempted to alter the natural state of their environment, and Amherst\u27s own Tan Brook is a local example of the consequences of human alterations on a stream. The brook flows over and under what many local citizens call home, and where many UMass students go to learn. A healthier Tan Brook would be expected to provide for improvement of ecosystem services such as flood control and nutrient processing, resulting in a cleaner campus pond and a better connection between the stream and the local community. The purpose of this study is to examine and compare previously recorded biochemical characteristics with current conditions in the Tan Brook and campus pond to determine if the health of this system has changed. Additional parameters related to the geomorphology and biology of the Tan Brook will also be characterized. Community concern in concurrence with the fact that the majority of the stream is piped underground through culverts indicates that the Tan Brook is currently impacted. The data collected can provide clues about levels of ecological impairment in Tan Brook and the source of these impairments. With interpretation, the information gathered could eventually lead to the development of infrastructure to remediate the sources of impairment, consequently leading to a cleaner Tan Brook. This is an optimistic transformation that would aid both the town of Amherst and the University

Brief analysis of the Tan Brook watershed in Amherst, Massachusetts

The Tan Brook is a small 3.91 square kilometer watershed that runs through and encompasses the highly urbanized areas of Amherst, MA. It is part of the Connecticut River basin and the Mill River sub-basin. In order to meet the high demands of the local middle and high school, and heavy runoff from high amounts of impervious cover from downtown Amherst and the University of Massachusetts, the Tan Brook has been highly culverted