A Basis for Civility

Give attention, if you will, to the virtue of civility. In this essay I want to define civility, then give a bit of its history, continue by predicting something of its future, and conclude by explaining civility\u27s true ground, at least as I understand it. We are not here interested in politeness or courtesy, though those meanings of civility may be ancillary to our topic. We are thinking instead about the political realm, and we are aware that many voices have been raised to decry the mean-spirited and vicious nature of politics, both in attaining and using public office. \Vise people warn us that democratic governance depends on a kind of self-control, by which the participants in the process guard it against internal meltdown. We ought to give careful attention to civility, for democracy may depend on it. Readers may find much to which they object in this essay, but they will agree that it marks off an interesting topic for discussion. Suggested corrections, at any point, are welcome. The most important thing comes last, for I hope readers will approve of what I say about the ground of civility even if they disagree with my account of what it is, what its history has been, or what its future may be

On Being Us: Who Are We, and What is This Book About? - Chapter 1 of Being at Home in the World: A New Christian Apologetic

This chapter introduces the authors and explains why we have written a book of Christian apologetics. It is important that the authors introduce themselves, because our apologetic procedure is personal. We do not offer a cool, detached, objective argument; instead, we extend an invitation

Book Reviews

Teaching/Communication/Extension/Profession,

OH 1720 MHz Masers in Supernova Remnants --- C-Shock Indicators

Recent observations show that the OH 1720 MHz maser is a powerful probe of the shocked region where a supernova remnant strikes a molecular cloud. We perform a thorough study of the pumping of this maser and find tight constraints on the physical conditions needed for its production. The presence of the maser implies moderate temperatures (50 -- 125 K) and densities ($\sim 10^5 cm^{-3}$), and OH column densities of order $10^{16} cm^{-2}$. We show that these conditions can exist only if the shocks are of C-type. J-shocks fail by such a wide margin that the presence of this maser could become the most powerful indicator of C-shocks. These conditions also mean that the 1720 MHz maser will be inherently weak compared to the other ground state OH masers. All the model predictions are in good agreement with the observations.Comment: 16 pages, 5 Postscript figures (included), uses aaspp4.sty. To appear in the Astrophysical Journa

MObile Technology for Improved Family Planning Services (MOTIF): study protocol for a randomised controlled trial.

BACKGROUND: Providing women with contraceptive methods following abortion is important to reduce repeat abortion rates, yet evidence for effective post-abortion family planning interventions are limited. This protocol outlines the evaluation of a mobile phone-based intervention using voice messages to support post-abortion family planning in Cambodia. METHODS/DESIGN: A single blind randomised controlled trial of 500 participants. Clients aged 18 or over, attending for abortion at four Marie Stopes International clinics in Cambodia, owning a mobile phone and not wishing to have a child at the current time are randomised to the mobile phone-based intervention or control (standard care) with a 1:1 allocation ratio.The intervention comprises a series of six automated voice messages to remind clients about available family planning methods and provide a conduit for additional support. Clients can respond to message prompts to request a phone call from a counsellor, or alternatively to state they have no problems. Clients requesting to talk to a counsellor, or who do not respond to the message prompts, receive a call from a Marie Stopes International Cambodia counsellor who provides individualised advice and support regarding family planning. The duration of the intervention is 3 months. The control group receive existing standard of care without the additional mobile phone-based support.We hypothesise that the intervention will remind clients about contraceptive methods available, identify problems with side effects early and provide support, and therefore increase use of post-abortion family planning, while reducing discontinuation and unsafe method switching.Participants are assessed at baseline and at 4 months. The primary outcome measure is use of an effective modern contraceptive method at 4 months post abortion. Secondary outcome measures include contraception use, pregnancy and repeat abortion over the 4-month post-abortion period.Risk ratios will be used as the measure of effect of the intervention on the outcomes, and these will be estimated with 95% confidence intervals. All analyses will be based on the 'intention to treat' principle. DISCUSSION: This study will provide evidence on the effectiveness of a mobile phone-based intervention using voice messages to support contraception use in a population with limited literacy. Findings could be generalisable to similar populations in different settings. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01823861

Examining the theory of challenge and threat states in athletes: do predictions extend to academic performance?

Challenge and threat responses have been seen to predict success in meaningful performance environments, however, it is not as clear whether challenge and threat states predict academic outcomes. We tested if predictions from the Theory of Challenge and Threat in Athletes (TCTSA) can be extended to an academic context, by considering antecedents and outcomes of challenge and threat states as well as whether cardiovascular markers predicted academic performance. Thirty-six undergraduate students were asked to give speeches on an academic topic, and their cardiovascular responses, overall annual marks, and marks in a specific presentation assessment were recorded. Challenge and threat indexes failed to predict either of the performance measures. Limited support was found for other hypothesised relationships of the TCTSA, with challenge states predicting greater reinvestment, which was opposite to that hypothesised. Results suggest that predictions of the TCTSA may not be as pertinent in understanding goal pursuit in academic settings

Examining the Predictors of Mental Ill Health in Esport Competitors

Few research studies have examined the predictors of mental ill health in esports. This study addresses that gap by investigating stressors, sleep, burnout, social phobia anxiety and mental ill health in esport athletes. An online survey was disseminated to competitive student esport athletes (n = 313) residing in the UK. The survey included measures of stressors resulting from competing in esports, sleep quality, burnout, and social phobia, as well as outcome measures of mental ill health. Hierarchical regression analyses examined these relationships. All the hypotheses were supported, with stressors significantly predicting sleep quality, burnout, and social phobia anxiety, and stressors, sleep quality, burnout, and social phobia anxiety were all significant positive predictors of mental ill health. The strength of these predictions varied, for example, the daytime dysfunction subscale of sleep was a strong predictor of all outcome variables; two subscales of burnout, reduced sense of accomplishment and exhaustion significantly predicted each of the three mental ill health outcome variables, and two subscales of social phobia anxiety, fear and avoidance, significantly predicted mental ill health. Our study has important implications for player health in esports, highlighting interventions that could target specific aspects of stress, sleep, burnout, and social phobia anxiety to improve the mental health of those who compete in esports

Effect of a mobile phone-based intervention on post-abortion contraception: a randomized controlled trial in Cambodia.

OBJECTIVE: To assess the effect of a mobile phone-based intervention (mHealth) on post-abortion contraception use by women in Cambodia. METHODS: The Mobile Technology for Improved Family Planning (MOTIF) study involved women who sought safe abortion services at four Marie Stopes International clinics in Cambodia. We randomly allocated 249 women to a mobile phone-based intervention, which comprised six automated, interactive voice messages with counsellor phone support, as required, whereas 251 women were allocated to a control group receiving standard care. The primary outcome was the self-reported use of an effective contraceptive method, 4 and 12 months after an abortion. FINDINGS: Data on effective contraceptive use were available for 431 (86%) participants at 4 months and 328 (66%) at 12 months. Significantly more women in the intervention than the control group reported effective contraception use at 4 months (64% versus 46%, respectively; relative risk, RR: 1.39; 95% confidence interval, CI: 1.17-1.66) but not at 12 months (50% versus 43%, respectively; RR: 1.16; 95% CI: 0.92-1.47). However, significantly more women in the intervention group reported using a long-acting contraceptive method at both follow-up times. There was no significant difference between the groups in repeat pregnancies or abortions at 4 or 12 months. CONCLUSION: Adding a mobile phone-based intervention to abortion care services in Cambodia had a short-term effect on the overall use of any effective contraception, while the use of long-acting contraceptive methods lasted throughout the study period

A bioluminescent microbial biosensor for in vitro pretreatment assessment of cytarabine efficacy in leukemia

BACKGROUND: The nucleoside analog cytarabine (Ara-C [cytosine arabinoside]) is the key agent for treating acute myeloid leukemia (AML); however, up to 30% of patients fail to respond to treatment. Screening of patient blood samples to determine drug response before commencement of treatment is needed. This project aimed to construct and evaluate a self-bioluminescent reporter strain of Escherichia coli for use as an Ara-C biosensor and to design an in vitro assay to predict Ara-C response in clinical samples. METHODS: Weused transposition mutagenesis to create a cytidine deaminase (cdd)-deficient mutant of E. coli MG1655 that responded to Ara-C. The strain was transformed with the luxCDABE operon and used as a whole-cell biosensor for development an 8-h assay to determine Ara-C uptake and phosphorylation by leukemic cells. RESULTS: Intracellular concentrations of 0.025 μmol/L phosphorylated Ara-C were detected by significantly increased light output (P < 0.05) from the bacterial biosensor. Results using AML cell lines with known response to Ara-C showed close correlation between the 8-h assay and a 3-day cytotoxicity test for Ara-C cell killing. In retrospective tests with 24 clinical samples of bone marrow or peripheral blood, the biosensor-based assay predicted leukemic cell response to Ara-C within 8 h. CONCLUSIONS: The biosensor-based assay may offer a predictor for evaluating the sensitivity of leukemic cells to Ara-C before patients undergo chemotherapy and allow customized treatment of drug-sensitive patients with reduced Ara-C dose levels. The 8-h assay monitors intracellular Ara-CTP (cytosine arabinoside triphosphate) levels and, if fully validated, may be suitable for use in clinical settings. © 2010 American Association for Clinical Chemistry

Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly surgical patients

This is the protocol for a review and there is no abstract. The objectives are as follows: To compare maintenance of general anaesthesia for elderly surgical patients using total intravenous anaesthesia (TIVA) or inhalational anaesthesia on postoperative cognitive function, mortality, risk of hypotension, length of stay in the postanaesthetic care unit (PACU), and hospital stay