5,203 research outputs found
Management and treatment outcomes of patients enrolled in MDR-TB treatment in Viet Nam.
SETTING: The programmatic management of drug-resistant tuberculosis (TB) in Viet Nam has been rapidly scaled up since 2009. OBJECTIVES: To document the annual numbers of patients enrolled for multidrug-resistant tuberculosis (MDR-TB) treatment during 2010-2014 and to determine characteristics and treatment outcomes of patients initiating treatment during 2010-2012. DESIGN: A retrospective cohort study using national reports and data from the national electronic data system for drug-resistant TB. RESULTS: The number of patients enrolled annually for MDR-TB treatment increased from 97 in 2010 to 1522 in 2014. The majority of patients were middle-aged men who had pulmonary disease and had failed a retreatment regimen; 77% had received ⩾2 courses of TB treatment. Favourable outcomes (cured and treatment completed) were attained in 73% of patients. Unfavourable outcomes included loss to follow-up (12.5%), death (8%) and failure (6.3%). Having had ⩾2 previous treatment courses and being human immunodeficiency virus-positive were associated with unfavourable outcomes. CONCLUSION: Increasing numbers of patients are being treated for MDR-TB each year with good treatment outcomes under national programme management in Viet Nam. However, there is a need to increase case detection-currently at 30% of the estimated 5100 MDR-TB cases per year, reduce adverse outcomes and improve monitoring and evaluation
Geographical variation in the high-duty cycle echolocation of the cryptic common mustached bat Pteronotus cf. rubiginosus (Mormoopidae)
The use of bioacoustics as a tool for bat research is rapidly increasing worldwide. There is substantial evidence that environmental factors such as weather conditions or habitat structure can affect echolocation call structure in bats and thus compromise proper species identification. However, intraspecific differences in echolocation due to geographical variation are poorly understood, which poses a number of issues in terms of method standardization. We examined acoustic data for Pteronotus cf. rubiginosus from the Central Amazon and the Guiana Shield. We provide the first evidence of intraspecific geographic variation in bat echolocation in the Neotropics, with calls significantly differing in almost all standard acoustic parameters for the two lineages of this clade. We complement our bioacoustic data with molecular and morphological data for both species. Considerable overlap in trait values prevents reliable discrimination between the two sympatric Pteronotus based on morphological characters. On the other hand, significant divergence in the frequency of maximum energy suggests that bioacoustics can be used to readily separate both taxa despite extensive intraspecific variability in their echolocation across the Amazon. Given the relative lack of barriers preventing contact between bat populations from the Central Amazon and French Guiana, the documented acoustic variation needs to be further studied in geographically intermediate locations to understand the potential isolation processes that could be causing the described divergence in echolocation and to determine whether this variation is either discrete or continuous
Improving the lens design and performance of a contemporary electromagnetic shock wave lithotripter.
The efficiency of shock wave lithotripsy (SWL), a noninvasive first-line therapy for millions of nephrolithiasis patients, has not improved substantially in the past two decades, especially in regard to stone clearance. Here, we report a new acoustic lens design for a contemporary electromagnetic (EM) shock wave lithotripter, based on recently acquired knowledge of the key lithotripter field characteristics that correlate with efficient and safe SWL. The new lens design addresses concomitantly three fundamental drawbacks in EM lithotripters, namely, narrow focal width, nonidealized pulse profile, and significant misalignment in acoustic focus and cavitation activities with the target stone at high output settings. Key design features and performance of the new lens were evaluated using model calculations and experimental measurements against the original lens under comparable acoustic pulse energy (E+) of 40 mJ. The -6-dB focal width of the new lens was enhanced from 7.4 to 11 mm at this energy level, and peak pressure (41 MPa) and maximum cavitation activity were both realigned to be within 5 mm of the lithotripter focus. Stone comminution produced by the new lens was either statistically improved or similar to that of the original lens under various in vitro test conditions and was significantly improved in vivo in a swine model (89% vs. 54%, P = 0.01), and tissue injury was minimal using a clinical treatment protocol. The general principle and associated techniques described in this work can be applied to design improvement of all EM lithotripters
Anisotropic interactions of a single spin and dark-spin spectroscopy in diamond
The nitrogen-vacancy (N-V) center in diamond is a promising atomic-scale
system for solid-state quantum information processing. Its spin-dependent
photoluminescence has enabled sensitive measurements on single N-V centers,
such as: electron spin resonance, Rabi oscillations, single-shot spin readout
and two-qubit operations with a nearby 13C nuclear spin. Furthermore, room
temperature spin coherence times as long as 58 microseconds have been reported
for N-V center ensembles. Here, we have developed an angle-resolved
magneto-photoluminescence microscopy apparatus to investigate the anisotropic
electron spin interactions of single N-V centers at room temperature. We
observe negative peaks in the photoluminescence as a function of both magnetic
field magnitude and angle that are explained by coherent spin precession and
anisotropic relaxation at spin level anti-crossings. In addition, precise field
alignment unmasks the resonant coupling to neighboring dark nitrogen spins that
are not otherwise detected by photoluminescence. The latter results demonstrate
a means of investigating small numbers of dark spins via a single bright spin
under ambient conditions.Comment: 13 pages, 4 figure
MAESTRI Toolkit for Industrial Symbiosis: overview, lessons learnt and implications
This paper presents a structured approach to support the development of self-organized industrial symbiosis, the Toolkit for Industrial Symbiosis. Developed within MAESTRI project, it provides a set of tools and methods to help companies gain value from wasted resources and contributes to MAESTRI goal of advancing the sustainability of European manufacturing and process industry. A participatory approach was taken for its development. The ultimate objective of this work is to encourage companies to change their attitude and consider waste as a resource and potential source for value creation
Cough and its importance in COPD
Patients with COPD most frequently complain of breathlessness and cough and these are both increased during exacerbations. Studies have generally focused on quality of life during end-stage disease, where breathlessness becomes dominant and cough less important. There are very little data on the frequency and severity of cough in COPD or its impact on quality of life at different stages of disease. Little is known about the factors that influence objective cough counts in COPD. Cough may be a marker for progressive disease in milder COPD patients who continue to smoke, and it may be useful in case-finding for milder disease in the community. The cough reflex sensitivity is heightened in COPD compared with healthy volunteers and similar to that in subjects with asthma. The degree of airflow obstruction does not predict cough reflex sensitivity or objective cough counts, implying an independent process. Effective treatments for cough in COPD have not yet been identified. Improved outcome measures of cough, a better understanding of cough in the natural history of COPD, and its importance to patients are needed
Composition and distribution of the peracarid crustacean fauna along a latitudinal transect off Victoria Land (Ross Sea, Antarctica) with special emphasis on the Cumacea
The following study was the first to describe composition and structure of the peracarid fauna systematically along a latitudinal transect off Victoria Land (Ross Sea, Antarctica). During the 19th Antarctic expedition of the Italian research vessel “Italica” in February 2004, macrobenthic samples were collected by means of a Rauschert dredge with a mesh size of 500 m at depths between 85 and 515 m. The composition of peracarid crustaceans, especially Cumacea was investigated. Peracarida contributed 63% to the total abundance of the fauna. The peracarid samples were dominated by amphipods (66%), whereas cumaceans were represented with 7%. Previously, only 13 cumacean species were known, now the number of species recorded from the Ross Sea increased to 34. Thus, the cumacean fauna of the Ross Sea, which was regarded as the poorest in terms of species richness, has to be considered as equivalent to that of other high Antarctic areas. Most important cumacean families concerning abundance and species richness were Leuconidae, Nannastacidae, and Diastylidae. Cumacean diversity was lowest at the northernmost area (Cape Adare). At the area off Coulman Island, which is characterized by muddy sediment, diversity was highest. Diversity and species number were higher at the deeper stations and abundance increased with latitude. A review of the bathymetric distribution of the Cumacea from the Ross Sea reveals that most species distribute across the Antarctic continental shelf and slope. So far, only few deep-sea records justify the assumption of a shallow-water–deep-sea relationship in some species of Ross Sea Cumacea, which is discussed from an evolutionary point of view
Atomic excitation during recollision-free ultrafast multi-electron tunnel ionization
Modern intense ultrafast pulsed lasers generate an electric field of
sufficient strength to permit tunnel ionization of the valence electrons in
atoms. This process is usually treated as a rapid succession of isolated
events, in which the states of the remaining electrons are neglected. Such
electronic interactions are predicted to be weak, the exception being
recollision excitation and ionization caused by linearly-polarized radiation.
In contrast, it has recently been suggested that intense field ionization may
be accompanied by a two-stage `shake-up' reaction. Here we report a unique
combination of experimental techniques that enables us to accurately measure
the tunnel ionization probability for argon exposed to 50 femtosecond laser
pulses. Most significantly for the current study, this measurement is
independent of the optical focal geometry, equivalent to a homogenous electric
field. Furthermore, circularly-polarized radiation negates recollision. The
present measurements indicate that tunnel ionization results in simultaneous
excitation of one or more remaining electrons through shake-up. From an atomic
physics standpoint, it may be possible to induce ionization from specific
states, and will influence the development of coherent attosecond XUV radiation
sources. Such pulses have vital scientific and economic potential in areas such
as high-resolution imaging of in-vivo cells and nanoscale XUV lithography.Comment: 17 pages, 4 figures, original format as accepted by Nature Physic
The small GTPase Rab29 is a common regulator of immune synapse assembly and ciliogenesis
Acknowledgements We wish to thank Jorge Galán, Gregory Pazour, Derek Toomre, Giuliano Callaini, Joel Rosenbaum, Alessandra Boletta and Francesco Blasi for generously providing reagents and for productive discussions, and Sonia Grassini for technical assistance. The work was carried out with the financial support of Telethon (GGP11021) and AIRC.Peer reviewedPostprin
Attenuation Imaging with Pulse-Echo Ultrasound based on an Acoustic Reflector
Ultrasound attenuation is caused by absorption and scattering in tissue and
is thus a function of tissue composition, hence its imaging offers great
potential for screening and differential diagnosis. In this paper we propose a
novel method that allows to reconstruct spatial attenuation distribution in
tissue based on computed tomography, using reflections from a passive acoustic
reflector. This requires a standard ultrasound transducer operating in
pulse-echo mode, thus it can be implemented on conventional ultrasound systems
with minor modifications. We use calibration with water measurements in order
to normalize measurements for quantitative imaging of attenuation. In contrast
to earlier techniques, we herein show that attenuation reconstructions are
possible without any geometric prior on the inclusion location or shape. We
present a quantitative evaluation of reconstructions based on simulations,
gelatin phantoms, and ex-vivo bovine skeletal muscle tissue, achieving
contrast-to-noise ratio of up to 2.3 for an inclusion in ex-vivo tissue.Comment: Accepted at MICCAI 2019 (International Conference on Medical Image
Computing and Computer Assisted Intervention
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