Preference for Plants in an Office Environment

Plants in the workplace are known to bring a number of benefits including psychological as well as aesthetic and air quality benefits. Therefore, plants can have an impact on overall organisational performance. However, findings of previous studies have rarely been applied in the FM context and yet strategic FM delivery in improving workplace productivity is essential for business survival. The paper explores the importance of interior plants in maintaining the physical and psychological well-being of office occupants utilising a survey of participants’ perceptions of photographs of an office with various levels of planting installed from no plants up to very high levels of planting. The paper provides preliminary results of a longer programme of research into the benefits of plants within the FM context. The work demonstrates that a reasonable level of interior planting in offices is preferred over offices with no plants. These perceived benefits may have a direct impact on overall organisational performance and therefore incorporating elements of nature within building design and management may in future be considered imperative to achieving the desired strategic outcomes of the organisation

Total Quality Facilities Management and Innovation: A Synergistic Approach

The ideas of quality and performance management and innovation in facilities management service provision are not new. Total Quality Management (TQM) is widely recognised throughout the world as a concept capable of providing competitive advantage. Innovation has also received considerable attention as having a crucial role in securing sustainable competitive advantage. However, there has been little consideration of the potential for integration of TQM practices with innovation principles in determining facilities management performance. TQM and innovation appear to corroborate each other and are becoming increasingly important in facilities management. This study takes a theoretical approach to critically review the relationship between TQM and innovation and to determine the relationship between TQM and Innovation in regard to facilities service provision. The theoretical implication is that FM service providers may adopt a synergistic approach to TQM and innovation, leading to sustained competitive advantage in terms of better positioning themselves within the saturated FM marketplace

Stochastic abstraction of programs: towards performance-driven development

Distributed computer systems are becoming increasingly prevalent, thanks to modern technology, and this leads to significant challenges for the software developers of these systems. In particular, in order to provide a certain service level agreement with users, the performance characteristics of the system are critical. However, developers today typically consider performance only in the later stages of development, when it may be too late to make major changes to the design. In this thesis, we propose a performance driven approach to development — based around tool support that allows developers to use performance modelling techniques, while still working at the level of program code. There are two central themes to the thesis. The first is to automatically relate performance models to program code. We define the Simple Imperative Remote Invocation Language (SIRIL), and provide a probabilistic semantics that interprets a program as a Markov chain. To make such an interpretation both computable and efficient, we develop an abstract interpretation of the semantics, from which we can derive a Performance Evaluation Process Algebra (PEPA) model of the system. This is based around abstracting the domain of variables to truncated multivariate normal measures. The second theme of the thesis is to analyse large performance models by means of compositional abstraction. We use two abstraction techniques based on aggregation of states — abstract Markov chains, and stochastic bounds — and apply both of them compositionally to PEPA models. This allows us to model check properties in the three-valued Continuous Stochastic Logic (CSL), on abstracted models. We have implemented an extension to the Eclipse plug-in for PEPA, which provides a graphical interface for specifying which states in the model to aggregate, and for performing the model checking

Online survey into the development of a model legal framework for a cannabis market in the United Kingdom

Background Despite rescheduling of cannabis to Schedule 2 and amendments to the law permitting legal availability of cannabis for the treatment of medical conditions, access to cannabis for medical use remains challenging for patients in the United Kingdom (UK). Recreational use is widespread despite laws stating users can be sentenced to prison for up to 5 years for possession. Objective The aim of the study was to develop a model for a legal cannabis market in the UK building upon the results of a preceding study in which a UK population sample determined that pharmacies are the most suitable primary legal vendor of cannabis as opposed to regulated shops or the black market. Methods An online survey was developed using Qualtrics software and advertised via the Multidisciplinary Association for Psychedelic Studies’ Facebook, Twitter and Instagram social media accounts and monthly newsletter. Results Three hundred and ninety seven individuals, a majority having used cannabis at least once, consented to participate in the study. The participants concluded that there is enough evidence for cannabis to be prescribed to treat a range of medical conditions. In addition to pharmacies providing cannabis to patients with a prescription, a majority of participants supported cannabis being sold in pharmacies for harm reduction purposes and allowing access to medicinal cannabis in cases where supporting evidence is insufficient to merit a prescription. Participants supported greater integration between dispensing pharmacies and mental health services. Overall, the participants did not oppose a consultation or screening for potential cannabis users prior to obtaining access from licensed vendors. UK participants were supportive of the concept of a cannabis card, which users can present to licensed vendors such as pharmacies, with specific recommendations (such as strains relevant to a patient’s medical condition) being coded into the card. A majority of participants supported the existence of shisha-type bars for the purchase and onsite consumption of cannabis and determined that such vendors should not be part of a pharmacy chain of stores or regulated by pharmacy regulators. The participants generally preferred that laws regarding public consumption are in line with existing smoking legislation. Participants determined that it should be legally permitted to grow cannabis at home for personal medical and non-medical purposes but not to sell for profit. Conclusion The results are suggestive of a regulatory system that medical and non-medical cannabis users can use which aims to maximise therapeutic applications, minimise harms and respect individual liberty

The Causes and Consequences of Nonenzymatic Protein Acylation.

Thousands of protein acyl modification sites have now been identified in vivo. However, at most sites the acylation stoichiometry is low, making functional enzyme-driven regulation in the majority of cases unlikely. As unmediated acylation can occur on the surface of proteins when acyl-CoA thioesters react with nucleophilic cysteine and lysine residues, slower nonenzymatic processes likely underlie most protein acylation. Here, we review how nonenzymatic acylation of nucleophilic lysine and cysteine residues occurs; the factors that enhance acylation at particular sites; and the strategies that have evolved to limit protein acylation. We conclude that protein acylation is an unavoidable consequence of the central role of reactive thioesters in metabolism. Finally, we propose a hypothesis for why low-stoichiometry protein acylation is selected against by evolution and how it might contribute to degenerative processes such as aging

Updates to the RMAP short-read mapping software

Summary: We report on a major new version of the RMAP software for mapping reads from short-read sequencing technology. General improvements to accuracy and space requirements are included, along with novel functionality. Included in the RMAP software package are tools for mapping paired-end reads, mapping using more sophisticated use of quality scores, collecting ambiguous mapping locations and mapping bisulfite-treated reads

Exercise Fails to Improve Neurocognition in Depressed Middle-Aged and Older Adults

Purpose: Although cross-sectional studies have demonstrated an association between higher levels of aerobic fitness and improved neurocognitive function, there have been relatively few interventional studies investigating this relationship, and results have been inconsistent. We assessed the effects of aerobic exercise on neurocognitive function in a randomized controlled trial of patients with major depressive disorder (MDD). Methods: Two-hundred and two sedentary men (n = 49) and women (n = 153), aged 40 yr and over and who met diagnostic criteria for MDD, were randomly assigned to the following: a) supervised exercise, b) home-based exercise, c) sertraline, or d) placebo pill. Before and after 4 months of treatment, participants completed measures of: Executive Function (Trail Making Test BA difference score, Stroop Color/Word, Ruff 2 & 7 Test, Digit Symbol), Verbal Memory (Logical Memory, Verbal Paired Associates), and Verbal Fluency/Working Memory (Animal Naming, Controlled Oral Word Association Test, Digit Span). Multivariate analyses of covariance were performed to test the effects of treatment on posttreatment neuropsychological test scores, with baseline neuropsychological test scores, age, education, and change in depression scores entered as covariates. Results: The performance of exercise participants was no better than participants receiving placebo across all neuropsychological tests. Exercise participants performed better than participants receiving sertraline on tests of executive function but not on tests of verbal memory or verbal fluency/ working memory. Conclusions: We found little evidence to support the benefits of an aerobic exercise intervention on neurocognitive performance in patients with MDD. Originally published Medicine and Science in Sport and Exercise, Vol. 40, No. 7, July 200