XLVIII.— Notes on volutharpa perryi

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Heaven Will Protect The Working Girl : A Burlesque Ballad

https://digitalcommons.library.umaine.edu/mmb-vp/1441/thumbnail.jp

Tungsten Hexabromide.

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XXX.— A list of the land and freshwater shells of Barbados

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Chandra X-ray Observatory Arcsecond Imaging of the Young, Oxygen-rich Supernova Remnant 1E0102.2-7219

We present observations of the young, Oxygen-rich supernova remnant 1E0102.2-7219 taken by the Chandra X-ray Observatory during Chandra's Orbital Activation and Checkout phase. The boundary of the blast wave shock is clearly seen for the first time, allowing the diameter of the remnant and the mean blast wave velocity to be determined accurately. The prominent X-ray bright ring of material may be the result of the reverse shock encountering ejecta; the radial variation of O VII vs. O VIII emission indicates an ionizing shock propagating inwards, possibly through a strong density gradient in the ejecta. We compare the X-ray emission to Australia Telescope Compact Array 6 cm radio observations (Amy and Ball) and to archival Hubble Space Telescope [O III] observations. The ring of radio emission is predominantly inward of the outer blast wave, consistent with an interpretation as synchrotron radiation originating behind the blast wave, but outward of the bright X-ray ring of emission. Many (but not all) of the prominent optical filaments are seen to correspond to X-ray bright regions. We obtain an upper limit of ~9e33 erg/s (3 sigma) on any potential pulsar X-ray emission from the central region.Comment: Accepted for pulication in Ap. J. Letters. 4 pages, 6 figures (one color figure). Formatted with emulateapj5. Revised to incorporate copyediting changes. High-resolution postscript (3.02MB) and tiff versions of the color figure are available from http://chandra.harvard.edu/photo/cycle1/0015multi/index.htm

Attitudes Toward Breast Cancer Genetic Testing in Five Special Population Groups

Purpose: This study examined interest in and attitudes toward genetic testing in 5 different population groups. Methods: The survey included African American, Asian American, Latina, Native American, and Appalachian women with varying familial histories of breast cancer. A total of 49 women were interviewed in person. Descriptive and nonparametric statistical techniques were used to assess ethnic group differences. Results: Overall, interest in testing was high. All groups endorsed more benefits than risks. There were group differences regarding endorsement of specific benefits and risks: testing to “follow doctor recommendations” (p=0.017), “concern for effects on family” (p=0.044), “distrust of modern medicine” (p=0.036), “cost” (p=0.025), and “concerns about communication of results to others” (p=0.032). There was a significant inverse relationship between interest and genetic testing cost (p Conclusion: Cost may be an important barrier to obtaining genetic testing services, and participants would benefit by genetic counseling that incorporates the unique cultural values and beliefs of each group to create an individualized, culturally competent program. Further research about attitudes toward genetic testing is needed among Asian Americans, Native Americans, and Appalachians for whom data are severely lacking. Future study of the different Latina perceptions toward genetic testing are encouraged

OPTN recruitment to a Golgi-proximal compartment regulates immune signalling and cytokine secretion

Optineurin (OPTN) is a multifunctional protein involved in autophagy, secretion as well as NF-κB and IRF3 signalling and OPTN mutations are associated with several human diseases. Here we show that, in response to viral RNA, OPTN translocates to foci in the perinuclear region, where it negatively regulates NF-κB and IRF3 signalling pathways and downstream pro-inflammatory cytokine secretion. These OPTN foci consist of a tight cluster of small membrane vesicles, which are positive for ATG9A. Disease mutations linked to POAG cause aberrant foci formation in the absence of stimuli, which correlates with the ability of OPTN to inhibit signalling. Using proximity labelling proteomics, we identify the LUBAC complex, CYLD and TBK1 as part of the OPTN interactome and show that these proteins are recruited to this OPTN-positive perinuclear compartment. Our work uncovers a crucial role for OPTN in dampening NF-κB and IRF3 signalling through the sequestration of LUBAC and other positive regulators in this viral RNA-induced compartment leading to altered pro-inflammatory cytokine secretion