Early increases in plasminogen activator activity following partial hepatectomy in humans

Background Increases in urokinase-like plasminogen activator (uPA) activity are reported to be amongst the earliest events occurring in remnant liver following partial hepatectomy in rats, and have been proposed as a key component of the regenerative response. Remodelling of the extracellular matrix, conversion of single chain hepatocyte growth factor to the active two-chain form and a possible activation of a mitogenic signalling pathway have all been ascribed to the increased uPA activity. The present study aimed to determine whether similar early increases in uPA activity could be detected in the remnant liver following resection of metastatic tumours in surgical patients. Results Eighteen patients undergoing partial hepatectomy for the removal of hepatic metastases secondary to primary colonic tumours were studied. Increased plasminogen activator activity was found in the final liver samples for the group of patients in whom the resection size was at least 50%. For smaller resections, the increased activity was not observed. The increased activity did not correlate with the age of the patient or with the time between the start of resection and the end of the operation. There was, however, a negative correlation between plasminogen activator activity and the time for which blood supply to the liver was clamped. Conclusions Our findings are in accordance with those from experimental animal models and show, for the first time, that rapid increases in plasminogen activator activity can occur following similarly large liver resection in humans. Thus, increases in plasminogen activator activity are an early event in the remnant liver following major liver resection in man. Our observations provide support for the contention that increases in plasminogen activators play a key role in the initiation of hepatic regeneration in man

Development of a High Temperature Heater using an Yttria Stabilized Zirconia Cored Brick Matrix

The Ames pilot heater is a ceramic regenerative heater that provides high temperature air for aerodynamic and combustion experiments. The development of this heater to provide a heat storage bed with temperature capability of about 4600 R is described. A bed was designed and installed having cored brick elements of yttria-stabilized zirconia. The bed dimensions were 14 inches in diameter by 10 feet high. The thermal stress limitations of the bed were studied and maximum air flow rates based upon these limits were established. A combustion reheat system was designed and installed to provide the necessary control over the bed temperature distribution. The revised heater system was successfully operated at a maximum bed temperature of 4600 R. The successful operation demonstrated that yttria-stabilized zirconia cored brick can satisfy the high temperature-long duration requirement for storage heater applications

Comparison of mass limiting two-phase flow in a straight tube and in a nozzle

Mass-limiting and near mass-limiting two-phase flow in straight tube and nozzle of refrigerant flow loop syste

A reference atmosphere for patrick afb, florida, annual /1963 revision/

Reference atmosphere for cape kennedy based on statistical parameters of pressure-height, temperature, and relative humidity at constant pressure level

Anomalous accelerations of the Pageos spacecraft

Anomalous accelerations of Pageos satellite and application of theory to predict perturbations in mean motio

Global Hot Gas in and around the Galaxy

The hot interstellar medium traces the stellar feedback and its role in regulating the eco-system of the Galaxy. I review recent progress in understanding the medium, based largely on X-ray absorption line spectroscopy, complemented by X-ray emission and far-UV OVI absorption measurements. These observations enable us for the first time to characterize the global spatial, thermal, chemical, and kinematic properties of the medium. The results are generally consistent with what have been inferred from X-ray imaging of nearby galaxies similar to the Galaxy. It is clear that diffuse soft X-ray emitting/absorbing gas with a characteristic temperature of $\sim 10^6$ K resides primarily in and around the Galactic disk and bulge. In the solar neighborhood, for example, this gas has a characteristic vertical scale height of $\sim 1$ kpc. This conclusion does not exclude the presence of a larger-scale, probably much hotter, and lower density circum-Galactic hot medium, which is required to explain observations of various high-velocity clouds. This hot medium may be a natural product of the stellar feedback in the context of the galaxy formation and evolution.Comment: 11 pages, invited talk in the workshop "The Local Bubble and Beyond II

Distributed Detection over Fading MACs with Multiple Antennas at the Fusion Center

A distributed detection problem over fading Gaussian multiple-access channels is considered. Sensors observe a phenomenon and transmit their observations to a fusion center using the amplify and forward scheme. The fusion center has multiple antennas with different channel models considered between the sensors and the fusion center, and different cases of channel state information are assumed at the sensors. The performance is evaluated in terms of the error exponent for each of these cases, where the effect of multiple antennas at the fusion center is studied. It is shown that for zero-mean channels between the sensors and the fusion center when there is no channel information at the sensors, arbitrarily large gains in the error exponent can be obtained with sufficient increase in the number of antennas at the fusion center. In stark contrast, when there is channel information at the sensors, the gain in error exponent due to having multiple antennas at the fusion center is shown to be no more than a factor of (8/pi) for Rayleigh fading channels between the sensors and the fusion center, independent of the number of antennas at the fusion center, or correlation among noise samples across sensors. Scaling laws for such gains are also provided when both sensors and antennas are increased simultaneously. Simple practical schemes and a numerical method using semidefinite relaxation techniques are presented that utilize the limited possible gains available. Simulations are used to establish the accuracy of the results.Comment: 21 pages, 9 figures, submitted to the IEEE Transactions on Signal Processin

High-power ac/dc variable load simulator

Design of medium-power dynamic electrical load simulator has been extended to permit simulation of ac as well as dc loads and to provide for operation at higher power levels. Simulator is internally protected against reverse voltage, overvoltage, overcurrent, and overload conditions