Probabilistic lower bounds on maximal determinants of binary matrices

Let ${\mathcal D}(n)$ be the maximal determinant for $n \times n$ $\{\pm 1\}$-matrices, and $\mathcal R(n) = {\mathcal D}(n)/n^{n/2}$ be the ratio of ${\mathcal D}(n)$ to the Hadamard upper bound. Using the probabilistic method, we prove new lower bounds on ${\mathcal D}(n)$ and $\mathcal R(n)$ in terms of $d = n-h$, where $h$ is the order of a Hadamard matrix and $h$ is maximal subject to $h \le n$. For example, $\mathcal R(n) > (\pi e/2)^{-d/2}$ if $1 \le d \le 3$, and $\mathcal R(n) > (\pi e/2)^{-d/2}(1 - d^2(\pi/(2h))^{1/2})$ if $d > 3$. By a recent result of Livinskyi, $d^2/h^{1/2} \to 0$ as $n \to \infty$, so the second bound is close to $(\pi e/2)^{-d/2}$ for large $n$. Previous lower bounds tended to zero as $n \to \infty$ with $d$ fixed, except in the cases $d \in \{0,1\}$. For $d \ge 2$, our bounds are better for all sufficiently large $n$. If the Hadamard conjecture is true, then $d \le 3$, so the first bound above shows that $\mathcal R(n)$ is bounded below by a positive constant $(\pi e/2)^{-3/2} > 0.1133$.Comment: 17 pages, 2 tables, 24 references. Shorter version of arXiv:1402.6817v4. Typos corrected in v2 and v3, new Lemma 7 in v4, updated references in v5, added Remark 2.8 and a reference in v6, updated references in v

The Social Costs of an MTBE Ban in California

Resource /Energy Economics and Policy,

Incontinence-specific quality of life measures used in trials of treatments for female urinary incontinence: a systematic review.

This systematic review examined the use of incontinence-specific QOL measures in clinical trials of female incontinence treatments, and systematically evaluated their quality using a standard checklist. Of 61 trials included in the review, 58 (95.1%) used an incontinence-specific QOL measure. The most commonly used were IIQ (19 papers), I-QoL (12 papers) and UDI (9 papers). Eleven papers (18.0%) used measures which were not referenced or were developed specifically for the study. The eight QOL measures identified had good clinical face validity and measurement properties. We advise researchers to evaluate carefully the needs of their specific study, and select the QOL measure that is most appropriate in terms of validity, utility and relevance, and discourage the development of new measures. Until better evidence is available on the validity and comparability of measures, we recommend that researchers consider using IIQ or I-QOL with or without UDI in trials of incontinence treatments

Reverse Innovation: An Opportunity for Strengthening Health Systems

BACKGROUND: Canada, when compared to other OECD countries, ranks poorly with respect to innovation and innovation adoption while struggling with increasing health system costs. As a result of its failure to innovate, the Canadian health system will struggle to meet the needs and demands of both current and future populations. The purpose of this initiative was to explore if a competition-based reverse innovation challenge could mobilize and stimulate current and future leaders to identify and lead potential reverse innovation projects that address health system challenges in Canada. METHODS: An open call for applications took place over a 4-month period. Applicants were enticed to submit to the competition with a $50,000 prize for the top submission to finance their project. Leaders from a wide cross-section of sectors collectively developed evaluation criteria and graded the submissions. The criteria evaluated: proof of concept, potential value, financial impact, feasibility, and scalability as well as the use of prize money and innovation team. RESULTS: The competition received 12 submissions from across Canada that identified potential reverse innovations from 18 unique geographical locations that were considered developing and/or emerging markets. The various submissions addressed health system challenges relating to education, mobile health, aboriginal health, immigrant health, seniors health and women\u27s health and wellness. Of the original 12 submissions, 5 finalists were chosen and publically profiled, and 1 was chosen to receive the top prize. CONCLUSIONS: The results of this initiative demonstrate that a competition that is targeted to reverse innovation does have the potential to mobilize and stimulate leaders to identify reverse innovations that have the potential for system level impact. The competition also provided important insights into the capacity of Canadian students, health care providers, entrepreneurs, and innovators to propose and implement reverse innovation in the context of the Canadian health system

An improved ontological representation of dendritic cells as a paradigm for all cell types

The Cell Ontology (CL) is designed to provide a standardized representation of cell types for data annotation. Currently, the CL employs multiple is_a relations, defining cell types in terms of histological, functional, and lineage properties, and the majority of definitions are written with sufficient generality to hold across multiple species. This approach limits the CL’s utility for cross-species data integration. To address this problem, we developed a method for the ontological representation of cells and applied this method to develop a dendritic cell ontology (DC-CL). DC-CL subtypes are delineated on the basis of surface protein expression, systematically including both species-general and species-specific types and optimizing DC-CL for the analysis of flow cytometry data. This approach brings benefits in the form of increased accuracy, support for reasoning, and interoperability with other ontology resources. 104. Barry Smith, “Toward a Realistic Science of Environments”, Ecological Psychology, 2009, 21 (2), April-June, 121-130. Abstract: The perceptual psychologist J. J. Gibson embraces a radically externalistic view of mind and action. We have, for Gibson, not a Cartesian mind or soul, with its interior theater of contents and the consequent problem of explaining how this mind or soul and its psychological environment can succeed in grasping physical objects external to itself. Rather, we have a perceiving, acting organism, whose perceptions and actions are always already tuned to the parts and moments, the things and surfaces, of its external environment. We describe how on this basis Gibson sought to develop a realist science of environments which will be ‘consistent with physics, mechanics, optics, acoustics, and chemistry’

Using Syndromic Surveillance to Assess the Impact of Environmental Factors on Asthma- and COPD- Related ED Visits in Douglas County, Nebraska

Background: Asthma and chronic obstructive pulmonary disease (COPD) are chronic diseases associated with health disparities in Douglas County, Nebraska and in the United States. Currently there is a lack of information describing the impact of environmental factors in Nebraska on the burden of emergency department (ED) visits or hospitalizations related to these chronic respiratory (CR) diseases. The aim of this study was to determine if there is an association between the numbers of seasonal viral respiratory (SVR)- related ED visits, outdoor air pollutants, aeroallergens, or meteorological factors on the number of CR- related ED visits in Douglas County, Nebraska. Methods: We analyzed electronic health record (EHR) data from 8 of 9 hospitals in Douglas County, NE for ED visits from February 28, 2016 to December 29, 2018. Syndromic surveillance definitions were used to identify CR- and SVR- related ED visits in EHR ED data. Aeroallergen, outdoor air pollutant and temperature data were obtained. Descriptive statistics were performed on EHR and environmental data. Negative binomial models were used to determine the association between the number of CR- related weekly ED visits and the environmental factors of interest. These models were stratified to account for possible cofounding effect of patient age and season. Patient age was stratified into 3 age groups: \u3c 18 yrs., 18-39 yrs., ≥ 40 yrs. Results: Significant associations were observed between the number of CR- related weekly ED visits and the weekly number of SVR-related ED visits, mean weed pollen counts, mean mold spore counts, mean minimum temperature, mean carbon monoxide levels and mean fine particulate matter (PM2.5) levels. Discrepancies in significant associations between the CR- related weekly ED visits and the environmental variables were observed after stratifying the model by season and age groups. For instance, SVR-related weekly ED visits were significantly associated with an increase in CR-related weekly ED visits among the \u3c 18 yrs. and 18 to 39 yrs. age groups in the summer, the ≥ 40 yrs. age group in the fall, and the 18 to 39 yrs. and the ≥ 40 yrs. age groups in the winter. Minimum temperature was significantly associated with the increase in CR- related weekly ED visits among the \u3c 18 yrs. and 18 to 39 yrs. age groups in the fall. Significant associations with an increase in CR- related weekly ED visits were also observed for PM2.5 among the 18 to 39 yrs. and ≥ 40 yrs. age groups in the spring, and the \u3c 18 yrs. and ≥ 40 yrs. age groups in the fall. Weed pollen and mold spores were also significantly associated with an increase in CR- related weekly ED visits. While significant associations were observed for weed pollen during the summer among the \u3c 18 yrs. age group, significant associations were observed for mold spores among all age groups during spring, and among the ≥ 40 yrs. age group during summer. Carbon monoxide was associated with a decrease in CR-related weekly ED visits for the 18 to 39 yrs. age group in the fall. Conclusions: Results of this study indicate the association between environmental factors and CR- related ED visits in Douglas County, Nebraska could be affected by not only by SVR disease cycles, temperature and other environmental factors, but also by age. Additional analyses may be needed to further explore these associations

DNA damage regulates direct association of TOR kinase with the RNA polymerase II-transcribed HMO1 gene

© 2017 Panday et al. The mechanistic target of rapamycin complex 1 (mTORC1) senses nutrient sufficiency and cellular stress. When mTORC1 is inhibited, protein synthesis is reduced in an intricate process that includes a concerted down-regulation of genes encoding rRNA and ribosomal proteins. The Saccharomyces cerevisiae high-mobility group protein Hmo1p has been implicated in coordinating this response to mTORC1 inhibition. We show here that Tor1p binds directly to the HMO1 gene (but not to genes that are not linked to ribosome biogenesis) and that the presence of Tor1p is associated with activation of gene activity. Persistent induction of DNA double-strand breaks or mTORC1 inhibition by rapamycin results in reduced levels of HMO1 mRNA, but only in the presence of Tor1p. This down-regulation is accompanied by eviction of Ifh1p and recruitment of Crf1p, followed by concerted dissociation of Hmo1p and Tor1p. These findings uncover a novel role for TOR kinase in control of gene activity by direct association with an RNA polymerase II-transcribed gene