Hadronic Spectral Moments in Semileptonic B Decays With a Lepton Energy Cut

We compute the first two moments of the final hadronic invariant mass in inclusive semileptonic B decay, in the presence of a cut on the charged lepton energy. These moments may be measured directly by experiments at the Upsilon(4S) using the neutrino reconstruction technique, which requires such a cut. Measurement of these moments will place constraints on the nonperturbative parameters \bar\Lambda and \lambda_1, which are relevant for extracting the quark masses m_b and m_c, as well as the CKM angle V_cb. We include terms of order \alpha_s^2\beta_0 and 1/m_b^3 in the operator product expansion, and use the latter to estimate the theoretical uncertainty in the extraction of \bar\Lambda and \lambda_1.Comment: 13 pages, 5 figures, REVTe

Hadron Spectra for Semileptonic Heavy Quark Decay

We calculate the leading perturbative and power corrections to the hadronic invariant mass and energy spectra in semileptonic heavy hadron decays. We apply our results to the $B$ system. Moments of the invariant mass spectrum, which vanish in the parton model, probe gluon bremsstrahlung and nonperturbative effects. Combining our results with recent data on $B$ meson branching ratios, we obtain a lower bound $\bar\Lambda>410\,{\rm MeV}$ and an upper bound $m_b^{\rm pole}<4.89\,$GeV. The Brodsky-Lepage-Mackenzie scale setting procedure suggests that higher order perturbative corrections are small for bottom decay, and even tractable for charm decay.Comment: 24 pages, uses REVTeX, 5 EPS figures embedded with epsf.sty, slightly modified version to appear in Phys. Rev.

SARS-CoV-2 Wastewater Genomic Surveillance: Approaches, Challenges, and Opportunities

During the SARS-CoV-2 pandemic, wastewater-based genomic surveillance (WWGS) emerged as an efficient viral surveillance tool that takes into account asymptomatic cases and can identify known and novel mutations and offers the opportunity to assign known virus lineages based on the detected mutations profiles. WWGS can also hint towards novel or cryptic lineages, but it is difficult to clearly identify and define novel lineages from wastewater (WW) alone. While WWGS has significant advantages in monitoring SARS-CoV-2 viral spread, technical challenges remain, including poor sequencing coverage and quality due to viral RNA degradation. As a result, the viral RNAs in wastewater have low concentrations and are often fragmented, making sequencing difficult. WWGS analysis requires advanced computational tools that are yet to be developed and benchmarked. The existing bioinformatics tools used to analyze wastewater sequencing data are often based on previously developed methods for quantifying the expression of transcripts or viral diversity. Those methods were not developed for wastewater sequencing data specifically, and are not optimized to address unique challenges associated with wastewater. While specialized tools for analysis of wastewater sequencing data have also been developed recently, it remains to be seen how they will perform given the ongoing evolution of SARS-CoV-2 and the decline in testing and patient-based genomic surveillance. Here, we discuss opportunities and challenges associated with WWGS, including sample preparation, sequencing technology, and bioinformatics methods.Comment: V Munteanu and M Saldana contributed equally to this work A Smith and S Mangul jointly supervised this work For correspondence: [email protected]

Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications.

Analysis of DNA methylation patterns relies increasingly on sequencing-based profiling methods. The four most frequently used sequencing-based technologies are the bisulfite-based methods MethylC-seq and reduced representation bisulfite sequencing (RRBS), and the enrichment-based techniques methylated DNA immunoprecipitation sequencing (MeDIP-seq) and methylated DNA binding domain sequencing (MBD-seq). We applied all four methods to biological replicates of human embryonic stem cells to assess their genome-wide CpG coverage, resolution, cost, concordance and the influence of CpG density and genomic context. The methylation levels assessed by the two bisulfite methods were concordant (their difference did not exceed a given threshold) for 82% for CpGs and 99% of the non-CpG cytosines. Using binary methylation calls, the two enrichment methods were 99% concordant and regions assessed by all four methods were 97% concordant. We combined MeDIP-seq with methylation-sensitive restriction enzyme (MRE-seq) sequencing for comprehensive methylome coverage at lower cost. This, along with RNA-seq and ChIP-seq of the ES cells enabled us to detect regions with allele-specific epigenetic states, identifying most known imprinted regions and new loci with monoallelic epigenetic marks and monoallelic expression

Measurement of Interfering K^*+K^- and K^*-K^+ Amplitudes in the Decay D^0 --> K^+K^-pi^0

We have studied the Cabibbo-suppressed decay mode D^0 into K^+ K^- pi^0 using a Dalitz plot technique and find the strong phase difference delta_D [defined as delta_(K*^- K^+) - delta_(K*^+ K^-)] = 332 degrees +- 8 degrees +- 11 degrees and relative amplitude r_D [defined as a_(K*^- K^+) / a_(K*^+ K^-)] = 0.52 +- 0.05 +- 0.04. This measurement indicates significant destructive interference between D^0 into K^+ (K^- pi^0)_K*^- and D^0 into K^- (K^+ pi^0)_K*^+ in the Dalitz plot region where these two modes overlap. This analysis uses 9.0 fb^(-1) of data collected at s^(1/2) of approximately 10.58 GeV with the CLEO III detector.Comment: 10 pages postscript,also available through http://www.lns.cornell.edu/public/CLNS/2006/, Submitted to Phys. Rev. D (Rapid Communications

Update of the measurement of the cross section for e^+e^- -> psi(3770) -> hadrons

We have updated our measurement of the cross section for e^+e^- -> psi(3770) -> hadrons, our publication "Measurement of sigma(e^+e^- -> psi(3770) -> hadrons) at E_{c.m.} = 3773 MeV", arXiv:hep-ex/0512038, Phys.Rev.Lett.96, 092002 (2006). Simultaneous with this arXiv update, we have published an erratum in Phys.Rev.Lett.104, 159901 (2010). There, and in this update, we have corrected a mistake in the computation of the error on the difference of the cross sections for e^+e^- -> psi(3770) -> hadrons and e^+e^- -> psi(3770) -> DDbar. We have also used a more recent CLEO measurement of cross section for e^+e^- -> psi(3770) -> DDbar. From this, we obtain an upper limit on the branching fraction for psi(3770) -> non-DDbar of 9% at 90% confidence level.Comment: 3 pages, 0 figures. This is an erratum to Phys.Rev.Lett.96:092002,2006. Added a reference

A Study of Exclusive Charmless Semileptonic B Decays and Extraction of |V_{ub}| at CLEO

We have studied semileptonic B decay to the exclusive charmless states pi, rho/omega, eta and eta' using the full 15.5 fb^-1 CLEO Upsilon(4S) sample, with measurements performed in subregions of phase space to minimize dependence on a priori knowledge of the form factors involved. We find total branching fractions B(B^0 -> pi^-l^+nu) = (1.37 +- 0.15_stat +- 0.11_sys) x 10^-4 and B(B^0 -> rho^- l^+ nu) = (2.93 +- 0.37_stat +- 0.37_sys) x 10^-4. We find evidence for B^+ -> eta' l^+ nu, with B(B^+ -> eta' l^+ nu) = (2.66 +- 0.80_stat +- 0.56_sys) x 10^-4 and 1.20 x 10^-4 eta' l^+ nu) < 4.46 x 10^-4 (90% CL). We also limit B(B^+ -> eta l^+ nu) < 1.01 x 10^-4 (90% CL). By combining our B -> pi l nu information with unquenched lattice calculations, we find |V_ub| = (3.6 +- 0.4 +- 0.2 +0.6 -0.4) x 10^-3, where the errors are statistical, experimental systematic, and theoretical systematic, respectively.Comment: 35 pages, 15 figures; revise

Search for Radiative Decays of Upsilon(1S) into eta and eta'

We report on a search for the radiative decay of Upsilon(1S) to the pseudoscalar mesons eta and etaprime in 21.2 +/- 0.2 times 10^6 Upsilon(1S) decays collected with the CLEO III detector at the Cornell Electron Storage Ring (CESR). The eta meson was reconstructed in the three modes eta to gamma-gamma, eta to pi+pi-pi0 and eta to 3pi0. The etaprime meson was reconstructed in the mode etaprime to pi+ pi- eta with eta decaying through any of the above three modes, and also etaprime to gamma rho, where rho decays to pi^+ pi^-. Five out of the seven sub-modes are found to be virtually background-free. In four of them we find no signal candidates and in one Upsilon(1S) to gamma-etaprime, etaprime to pi+ pi- eta, eta to pi+pi-pi0 there are two good signal candidates, which is insufficient evidence to claim a signal. The other two sub-modes eta to gamma-gamma and etaprime to gamma rho are background limited, and show no excess of events in their signal regions. We combine the results from different channels and obtain upper limits at the 90% C.L. which are B(Upsilon(1S) to gamma eta) < 1.0 times 10^-6 and B(Upsilon(1S) to gamma etaprime) < 1.9 times 10^-6. Our limits are an order of magnitude tighter than the previous ones and below the predictions made by some theoretical models.Comment: 14 pages postscript,also available through http://www.lns.cornell.edu/public/CLNS/2007/, Submitted to PR

Absolute Branching Fraction Measurements for D^+ and D^0 Inclusive Semileptonic Decays

We present measurements of the inclusive branching fractions for the decays D^+ -> X e^+ nu_e and D^0 -> X e^+ nu_e, using 281 pb^-1 of data collected on the psi(3770) resonance with the CLEO-c detector. We find Br(D^0 ->Xe^+\nu_e) = (6.46 \pm 0.17 \pm 0.13)% and Br((D^+ -> Xe^+nu_e) = (16.13 \pm 0.20 \pm 0.33)%. Using the known D meson lifetimes, we obtain the ratio Gamma{D^+}^sl/Gamma_{D^0}^sl= 0.985\pm 0.028\pm 0.015, confirming isospin invariance at the level of 3%. The positron momentum spectra from D^+ and D^0 have consistent shapes.Comment: 6 pages postscript,also available through this http://www.lns.cornell.edu/public/CLNS/2006

A Study of the Semileptonic Charm Decays D^0 --> pi^- e^+ nu_e, D^+ --> pi^0 e^+ nu_e, D^0 --> K^- e^+ nu_e, and D^+ --> barK^0 e^+ nu_e

Using a sample of 1.8 million DDbar meson pairs collected at the psi(3770) with the CLEO-c detector, we study the semileptonic decays D^0 -> pi^- e^+ nu_e, D^+ -> pi^0 e^+ \nu_e, D^0 -> K^- e^+ \nu_e, and D^+ -> Kbar^0 e^+ nu_e. For the total branching fractions we find B(D^0 -> pi^- e^+ \nu_e) = 0.299(11)(9)%, B(D^+ -> pi^0 e^+ \nu_e) = 0.373(22)(13)%, B(D^0 -> K^- e^+ nu_e) = 3.56(3)(9)%, and B(D^+ -> Kbar^0 e^+ nu_e) = 8.53(13)(23)%, where the first error is statistical and the second systematic. In addition, form factors are studied through fits to the partial branching fractions obtained in five q^2 ranges. By combining our results with recent unquenched lattice calculations, we obtain |Vcd| = 0.217(9)(4)(23) and |Vcs| = 1.015(10)(11)(106), where the final error is theoretical.Comment: 18 pages, postscript also available through http://www.lns.cornell.edu/public/CLNS/2006/, submitted to PR