Questioning, exploring, narrating and playing in the control room to maintain system safety

Systems whose design is primarily aimed at ensuring efficient, effective and safe working, such as control rooms, have traditionally been evaluated in terms of criteria that correspond directly to those values: functional correctness, time to complete tasks, etc. This paper reports on a study of control room working that identified other factors that contributed directly to overall system safety. These factors included the ability of staff to manage uncertainty, to learn in an exploratory way, to reflect on their actions, and to engage in problem-solving that has many of the hallmarks of playing puzzles which, in turn, supports exploratory learning. These factors, while currently difficult to measure or explicitly design for, must be recognized and valued in design

Photoactivatable metal complexes : from theory to applications in biotechnology and medicine

This short review highlights some of the exciting new experimental and theoretical developments in the field of photoactivatable metal complexes and their applications in biotechnology and medicine. The examples chosen are based on some of the presentations at the Royal Society Discussion Meeting in June 2012, many of which are featured in more detail in other articles in this issue. This is a young field. Even the photochemistry of well-known systems such as metal–carbonyl complexes is still being elucidated. Striking are the recent developments in theory and computation (e.g. time-dependent density functional theory) and in ultrafast-pulsed radiation techniques which allow photochemical reactions to be followed and their mechanisms to be revealed on picosecond/nanosecond time scales. Not only do some metal complexes (e.g. those of Ru and Ir) possess favourable emission properties which allow functional imaging of cells and tissues (e.g. DNA interactions), but metal complexes can also provide spatially controlled photorelease of bioactive small molecules (e.g. CO and NO)—a novel strategy for site-directed therapy. This extends to cancer therapy, where metal-based precursors offer the prospect of generating excited-state drugs with new mechanisms of action that complement and augment those of current organic photosensitizers

Compression properties of polymeric syntactic foam composites under cyclic loading

Syntactic foams are composite materials frequently used in applications requiring the properties of low density and high damage tolerance. In the present work, polymer-based syntactic foams were studied under cyclic compression in order to investigate their compressibility, recoverability, energy dissipation and damage tolerance. These syntactic foams were manufactured by adding hollow polymer microspheres of various sizes and wall thicknesses into a polyurethane matrix. The associated loading and unloading curves during cyclic testing were recorded, revealing the viscoelastic nature of the materials. SEM images of the samples were obtained in order to study potential damage mechanisms during compression. It was observed that these syntactic foams exhibit high elastic recovery and energy dissipation over a wide range of compressional strains and the addition of polymer microspheres mitigate the damage under compressional loading.Comment: 25 pages, 13 figure

XTE J1739-302 as a Supergiant Fast X-ray Transient

XTE J1739-302 is a transient X-ray source with unusually short outbursts, lasting on the order of hours. Here we give a summary of X-ray observations we have made of this object in outburst with the Rossi X-ray Timing Explorer (RXTE) and at a low level of activity with the Chandra X-ray Observatory, as well as observations made by other groups. Visible and infrared spectroscopy of the mass donor of XTE J1739-302 are presented in a companion paper. The X-ray spectrum is hard both at low levels and in outburst, but somewhat variable, and there is strong variability in the absorption column from one outburst to another. Although no pulsation has been observed, the outburst data from multiple observatories show a characteristic timescale for variability on the order of 1500-2000 s. The Chandra localization (right ascension 17h 39m 11.58s, declination -30o 20' 37.6'', J2000) shows that despite being located less than 2 degrees from the Galactic Center and highly absorbed, XTE J1739-302 is actually a foreground object with a bright optical counterpart. The combination of a very short outburst timescale and a supergiant companion is shared with several other recently-discovered systems, forming a class we designate as Supergiant Fast X-ray Transients (SFXTs). Three persistently bright X-ray binaries with similar supergiant companions have also produced extremely short, bright outbursts: Cyg X-1, Vela X-1, and 1E 1145.1-6141.Comment: 16 pages, 7 figures, 2 tables, in press in The Astrophysical Journal; see also the companion paper by Negueruela et a

The Very Massive Star Content of the Nuclear Star Clusters in NGC 5253

The blue compact dwarf galaxy NGC 5253 hosts a very young starburst containing twin nuclear star clusters, separated by a projected distance of 5 pc. One cluster (#5) coincides with the peak of the H-alpha emission and the other (#11) with a massive ultracompact H II region. A recent analysis of these clusters shows that they have a photometric age of 1+/-1 Myr, in apparent contradiction with the age of 3-5 Myr inferred from the presence of Wolf-Rayet features in the cluster #5 spectrum. We examine Hubble Space Telescope ultraviolet and Very Large Telescope optical spectroscopy of #5 and show that the stellar features arise from very massive stars (VMS), with masses greater than 100 Msun, at an age of 1-2 Myr. We further show that the very high ionizing flux from the nuclear clusters can only be explained if VMS are present. We investigate the origin of the observed nitrogen enrichment in the circum-cluster ionized gas and find that the excess N can be produced by massive rotating stars within the first 1 Myr. We find similarities between the NGC 5253 cluster spectrum and those of metal poor, high redshift galaxies. We discuss the presence of VMS in young, star-forming galaxies at high redshift; these should be detected in rest frame UV spectra to be obtained with the James Webb Space Telescope. We emphasize that population synthesis models with upper mass cut-offs greater than 100 Msun are crucial for future studies of young massive star clusters at all redshifts.Comment: 11 pages, 7 figures, accepted for publication in Astrophysical Journa

Realistic Ionizing Fluxes for Young Stellar Populations from 0.05 to twice solar metallicity

We present a new grid of ionizing fluxes for O and Wolf-Rayet stars for use with evolutionary synthesis codes and single star H II region analyses. A total of 230 expanding, non-LTE, line-blanketed model atmospheres have been calculated for five metallicities (0.05, 0.2, 0.4, 1 and 2 solar) using the WM-basic code of Pauldrach et al. (2001) and the CMFGEN code of Hillier & Miller (1998). The stellar wind parameters are scaled with metallicity for both O and W-R stars. We incorporate the new models into Starburst99 (Leitherer et al. 1999) and compare the ionizing outputs with Schaerer & Vacca (1998) and Leitherer et al. (1999). The changes in the output ionizing fluxes are dramatic, particularly below 228 A. We also find lower fluxes in the He I continuum for Z > 0.4 solar and ages < 7 Myr because of the increased line blanketing. We test the accuracy of the new models by constructing photoionization models. We show that for the dwarf O star grid, He I 5876/H beta decreases between Z = 1 and twice solar in a similar manner to observations (e.g. Bresolin et al. 1999) due to the increased effect of line blanketing. We therefore suggest that a lowering of the upper mass limit at high abundances is not required to explain the observations. For the case of an instantaneous burst, we plot the softness parameter "eta prime" against the abundance indicator R_23. The new models are coincident with the data of Bresolin et al. (1999), particularly during the W-R phase, unlike previous models which over-predict the hardness of the ionizing radiation.Comment: 21 pages, 15 postscript colour figures, includes mn2e.cls. To be published in MNRAS. Revised version containing modifications to Tables 1-

Propagation of sound through a sheared flow

Sound generated in a moving fluid must propagate through a shear layer in order to be measured by a fixed instrument. These propagation effects were evaluated for noise sources typically associated with single and co-flowing subsonic jets and for subcritical flow over airfoils in such jets. The techniques for describing acoustic propagation fall into two categories: geometric acoustics and wave acoustics. Geometric acoustics is most convenient and accurate for high frequency sound. In the frequency range of interest to the present study (greater than 150 Hz), the geometric acoustics approach was determined to be most useful and practical

Coulomb interactions in single, charged self-assembled quantum dots: radiative lifetime and recombination energy

We present results on the charge dependence of the radiative recombination lifetime, Tau, and the emission energy of excitons confined to single self-assembled InGaAs quantum dots. There are significant dot-to-dot fluctuations in the lifetimes for a particular emission energy. To reach general conclusions, we present the statistical behavior by analyzing data recorded on a large number of individual quantum dots. Exciton charge is controlled with extremely high fidelity through an n-type field effect structure, providing access to the neutral exciton (X0), the biexciton (2X0) and the positively (X1+) and negatively (X1-) charged excitons. We find significant differences in the recombination lifetime of each exciton such that, on average, Tau(X1-) / Tau(X0) = 1.25, Tau(X1+) / Tau(X0) = 1.58 and Tau(2X0) / Tau(X0) = 0.65. We attribute the change in lifetime to significant changes in the single particle hole wave function on charging the dot, an effect more pronounced on charging X0 with a single hole than with a single electron. We verify this interpretation by recasting the experimental data on exciton energies in terms of Coulomb energies. We show directly that the electron-hole Coulomb energy is charge dependent, reducing in value by 5-10% in the presence of an additional electron, and that the electron-electron and hole-hole Coulomb energies are almost equal.Comment: 8 pages, 7 figures, submitted to Phys. Rev.