Nieuwe vormen van samenwerking tussen ondernemers

Horizontale samenwerking -de samenwerking tussen ondernemers- is naast verticale samenwerking -de samenwerking in de keten- een manier om bedrijfs- en privédoelen beter te bereiken. Ondernemers die al samenwerken geven aan dat ze veel voordelen ondervinden in hun samenwerking. Die voordelen kunnen zo groot zijn, dat iedere agrarische of MKB-ondernemer toch een keer grondig zou moet overwegen om een samenwerkingsverband aan te gaa

Analysis of pleural fluid in idiopathic spontaneous pneumothorax; correlation of eosinophil percentage with the duration of air in the pleural space

AbstractPleural fluid analysis was performed in patients with idiopathic spontaneous pneumothorax. The objective of the study was to define the cell differentiation, and part of the cytokine profile, in relation to the duration of pneumothorax.In the 23 consecutive patients (19 men, mean age 34·2 years, 17 smokers), pleural fluid was obtained immediately after chest tube drainage (n=6), or during thoracoscopy (n=17). Cytospins were carried out, and supernatant analysis of the different cytokines was performed using sandwich ELISA. All concentrations were corrected for dilution.The duration of the pneumothorax was correlated with the rise in eosinophil percentage (r=0·81, P<0·00001) in pleural fluid. RANTES, platelet-activating factor (PAF), and monocyte chemotactic protein-1 (MCP-1) were detectable but no relationship with eosinophils or duration of the pneumothorax was found. Granulocyte-macrophage colony stimulating factor (GM-CSF) and interluekin-8 (IL-8) were not detectable. Interleukin-5 (IL-5) concentration correlated with the eosinophil concentration (r=0·84, P=0·037) and the eosinophil percentage (r=0·68, P=0·005) in the pleural fluid.Idiopathic spontaneous pneumothorax causes a time-related rise in the eosinophil percentage in the pleural space, which correlates with the level of IL-5

Richting nieuwe bedrijfssystemen : ondernemers en onderzoekers in gesprek over innovatie

In dit rapport hebben ondernemers en onderzoekers gezamenlijk een beeld geschetst van toekomstige ontwikkelingen in bedrijfssystemen in Nederland en per regio. Daarvoor is eerst inzicht gegeven in toekomstige trends, trendbreuken, maatschappelijke randvoorwaarden en verwachte internationale concurrentiepositie. Het rapport sluit af met een aantal innovatieopgaven en suggesties van de wijze waarop dit innovatieproces kan worden aangepakt. In this report, agricultural entrepreneurs and researchers collaborate to paint a picture of future developments in farming systems in the Netherlands and the country's four regions. To do this, the report first offers insight into future trends, breaks against trends, societal limiting conditions and the expected international competitiveness. The report concludes with a number of innovation problems and suggestions on the way in which to approach this innovation process

Carbon-13 magic-angle spinning NMR studies of bathorhodopsin, the primary photoproduct of rhodopsin

Bio-organic Synthesi

Non-linear excitations in Ising-type magnetic chain systems I: Mossbauer relaxation studies of antiferromagnets in zero and applied field

Quantum Matter and Optic

Samen werken aan samenwerking

Op het gebied van horizontale samenwerking is er veel mogelijk qua vorm, intensiteit, werkterrein en juridische constructie, zowel in de agrosector als in het mkb. De vele mogelijkheden bieden veel aangrijpingspunten om privé- en bedrijfsdoelen beter te kunnen bereiken, onder andere door meer denk- en slagkracht, ook financieel, en sociale voordelen als steun en meer vrije tijd. Samenwerking vraagt echter ook veel van de ondernemers en hun competenties. In dit onderzoek is vooral gekeken naar horizontale samenwerking: tussen soortgelijke ondernemers onderlin

Field-dependent Mossbauer relaxation study of domain walls in the quasi 1-d antiferromagnet RbFeCl3.2H2O

Quantum Matter and Optic

The prognostic value of early onset, CT derived loss of muscle and adipose tissue during chemotherapy in metastatic non-small cell lung cancer

Objectives: To evaluate the relationship between early changes in muscle and adipose tissue during chemotherapy and overall survival (OS) in stage IV non-small cell lung cancer (NSCLC). Materials and methods: In this post-hoc analysis of the first line NVALT12 trial (NCT01171170) in stage IV NSCLC, skeletal muscle (SM), radiation attenuation (RA), subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) were assessed at the third lumbar level on CT-images obtained before initiation of chemotherapy and shortly after administration of the second cycle. The contribution of changes in different body compartments to overall survival was assessed. Results: CT scans of 111 patients were included. Analysis of body composition changes between the baseline and the follow-up scan, revealed that overall SM cross sectional area (CSA), radiation attenuation and SAT CSA decreased respectively by −1.2 ± 2.9 cm2 /m2 (p < 0.001), −0.7 ± 3.3 HU (p = 0.026) and −1.9 ± 8.7 cm2 /m2 (p = 0.026), while no significant changes in VAT tissue were observed. Longitudinally, median OS was significantly shorter among patients losing SM compared to patients with preserved SM (9.4 versus 14.2 months; HR 1.9, 95% CI: 1.23, 2.79, p = 0.003). Multivariate analyses showed that proportional loss of muscle mass was associated with poor OS (HR 0.949, 95% CI: 0.915, 0.985, p = 0.006) independent from important clinical prognostic factors including WHO-PS, gender, age and Charlson comorbidity index. Conclusion: Early loss of SM during first line chemotherapy is a poor prognostic factor in stage IV NSCLC patients. Future studies have to reveal whether early supportive intervention guided by initial CT muscle response to chemotherapy can influence the wasting process and related mortality ris

Chemotherapy for pulmonary large cell neuroendocrine carcinomas: Does the regimen matter?

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Een leven lang leren; Voortdurende ontwikkeling van ondernemerscompetenties in kenniscoalities

Voor ondernemers in de land- en tuinbouw is het ontwikkelen van de eigen ondernemerschapscompetenties urgent als zij de komende jaren een belangrijke beslissing hebben te nemen over de ontwikkelingsrichting van het bedrijf