Самостоятельная работа студентов в профессиональных учебных заведениях

The reform of education in Russia has led to emergence of new learning pattern. Today, among numerous changes that have occurred in competence-based approach context, we note tendencies towards changes in teacher’s role in a student’s life, reduction in classroom hours and increase in the share of students’ independent work. In order to preserve and increase effectiveness of student learning, educational institutions should aim at finding new ways to use classroom hours to organize students' independent work. Insufficient knowledge of this topic actualizes the process of its further development. The purpose of our research was to verify the structure of independent work developed by the authors at a technical school in order to increase student training level. For this, the authors conducted an experiment in which two groups of second-year students of 25 people each took part. The results of the differentiated classification of two groups in the course "Engineering Graphics" were compared. The first group of students studied according to the structure available in the college, the second - with the help of the pattern developed by the authors. As a result, it was found that the second group has a higher level of training. The results of the experiment allowed us to conclude that the structure of independent work developed by the authors is very effective and its implementation will allow achieving positive results in students' competences development and in future graduates training.La reforma de la educación en Rusia ha llevado a la aparición de un nuevo patrón de aprendizaje. Hoy, entre los numerosos cambios que se han producido en el contexto del enfoque basado en la competencia, observamos tendencias hacia cambios en el papel del maestro en la vida de un estudiante, reducción en las horas de clase y aumento en la parte del trabajo independiente de los estudiantes. Para preservar y aumentar la efectividad del aprendizaje de los estudiantes, las instituciones educativas deben apuntar a encontrar nuevas formas de usar las horas de clase para organizar el trabajo independiente de los estudiantes. El conocimiento insuficiente de este tema actualiza el proceso de su desarrollo posterior. El propósito de nuestra investigación fue verificar la estructura del trabajo independiente desarrollado por los autores en una escuela técnica para aumentar el nivel de capacitación de los estudiantes. Para ello, los autores realizaron un experimento en el que participaron dos grupos de estudiantes de segundo año de 25 personas cada uno. Se compararon los resultados de la clasificación diferenciada de dos grupos en el curso "Gráficos de ingeniería". El primer grupo de estudiantes estudió de acuerdo con la estructura disponible en la universidad, el segundo, con la ayuda del patrón desarrollado por los autores. Como resultado, se encontró que el segundo grupo tiene un mayor nivel de entrenamiento. Los resultados del experimento nos permitieron concluir que la estructura del trabajo independiente desarrollado por los autores es muy efectiva y su implementación permitirá lograr resultados positivos en el desarrollo de competencias de los estudiantes y en la formación de futuros graduados.Реформа образования в России привела к появлению новой модели обучения. Сегодня среди многочисленных изменений, произошедших в контексте компетентностного подхода, мы отмечаем тенденции к изменению роли педагога в жизни студента, сокращению аудиторных часов и увеличению доли самостоятельной работы студентов. Чтобы сохранить и повысить эффективность обучения студентов, учебные заведения должны стремиться найти новые способы использования аудиторных часов для организации самостоятельной работы студентов. Недостаточная разработка этой темы актуализирует процесс ее дальнейшего развития. Целью нашего исследования была проверка структуры самостоятельной работы, разработанной авторами в техникуме с целью повышения уровня подготовки студентов. Для этого авторы провели эксперимент, в котором приняли участие две группы студентов второго курса по 25 человек в каждой. Результаты дифференцированной классификации двух групп по курсу «Инженерная графика» сравнивались. Первая группа студентов обучалась по структуре, имеющейся в колледже, вторая - по схеме, разработанной авторами. В результате выяснилось, что вторая группа имеет более высокий уровень подготовки. Результаты эксперимента позволили сделать вывод о том, что разработанная авторами структура самостоятельной работы имеет высокую результативность, а ее реализация позволит достичь положительных результатов в развитии компетенций студентов и в подготовке будущих выпускников

Eligibility for social services: social policy development in an international context

The article provides a frame of reference for reviewing the basic processes underlying the development of formal social policy. The bases for the article were provided by: (1) review of the literature in related social services policy development areas; (2) analyses and review of the literature specific to service eligibility; (3) analyses of related socio-economic data from international organizations and registries. Eligibility is proposed as an essential element of social services within the context of citizens’ rights, cultural mores and customs, political processes and economic conditions of the six contributing countries. These data sources were augmented by review of summary narratives of the history and status of social services development.O artigo apresenta um quadro de referência para a revisão dos processos fundamentais subjacentes ao desenvolvimento de políticas sociais formais. O artigo baseia-se em: (1) revisão de literatura das áreas de desenvolvimento das políticas de serviço social; 2) análise e revisão de literatura específica sobre a elegibilidade dos serviços; 3) análise de registos e dados socioeconómicos de organizações internacionais e registos. A elegibilidade é proposta como um elemento essencial dos serviços sociais no contexto dos direitos dos cidadãos, costumes culturais e valores, processos políticos e condições económicas dos seis países contribuintes. Estas fontes de informação foram ampliadas pela revisão de resumos de narrativas da história e estado de desenvolvimento dos serviços sociais.Cet article présente un canevas pour la révision des processus fondamentaux qui sous-tendent la mise en œuvre de politiques sociales formelles, en se basant sur : (1) la révision de la littérature des domaines de développement des politiques de protection sociale ; 2) l’analyse et la révision de la littérature spécifique sur l’éligibilité aux prestations ; 3) l’analyse des fichiers et des données socioéconomiques d’organisations internationales. L’éligibilité est proposée comme un élément essentiel des prestations sociales dans le contexte des droits des citoyens, des habitudes culturelles et des valeurs, des processus politiques et des conditions économiques des six pays contributeurs. Ces sources d’information ont été élargies par la révision de résumés de récits de l’histoire et de l’état de développement des services sociaux.El artículo presenta un marco de referencia para la revisión de los procesos fundamentales subyacentes al desarrollo de políticas sociales formales. El artículo se basa en: (1) revisión de literatura de las áreas de desarrollo de las políticas de servicio social; 2) análisis de la revisión de literatura específica sobre la elegibilidad de los servicios; 3) Análisis de registros y datos socioeconómicos de organizaciones internacionales y registros. La elegibilidad es propuesta como un elemento esencial de los servicios sociales en el contexto de los derechos de los ciudadanos, costumbres culturales  y valores, procesos políticos y condiciones económicas de sus países contribuyentes. Estas fuentes de información fueron ampliadas por la revisión de resúmenes de narrativas de la historia y estado de desarrollo de los servicios sociales

Staphylococcus aureus Panton‐Valentine Leukocidin triggers an alternative NETosis process targeting mitochondria

Panton-Valentine Leukocidin (PVL) is a bicomponent leukotoxin produced by 3%-10% of clinical Staphylococcus aureus (SA) strains involved in the severity of hospital and community-acquired infections. Although PVL was long known as a pore-forming toxin, recent studies have challenged the formation of a pore at the plasma membrane, while its endocytosis and the exact mode of action remain to be defined. In vitro immunolabeling of human neutrophils shows that Neutrophil Extracellular Traps (NETosis) is triggered by the action of purified PVL, but not by Gamma hemolysin CB (HlgCB), a structurally similar SA leukotoxin. PVL causes the ejection of chromatin fibers (NETs) decorated with antibacterial peptides independently of the NADPH oxidase oxidative burst. Leukotoxin partially colocalizes with mitochondria and enhances the production of reactive oxygen species from these organelles, while showing an increased autophagy, which results unnecessary for NETs ejection. PVL NETosis is elicited through Ca2+-activated SK channels and Myeloperoxidase activity but is abolished by Allopurinol pretreatment of neutrophils. Moreover, massive citrullination of the histone H3 is performed by peptidyl arginine deiminases. Inhibition of this latter enzymes fails to abolish NET extrusion. Unexpectedly, PVL NETosis does not seem to involve Src kinases, which is the main kinase family activated downstream the binding of PVL F subunit to CD45 receptor, while the specific kinase pathway differs from the NADPH oxidase-dependent NETosis. PVL alone causes a different and specific form of NETosis that may rather represent a bacterial strategy conceived to disarm and disrupt the immune response, eventually allowing SA to spread

Brazilian Portuguese-Russian (BraPoRus) Corpus: Automatic transcription and acoustic quality of elderly speech during Covid-19 pandemic

This article presents the Brazilian Portuguese-Russian (BraPoRus) corpus, whose goal is to collect, analyze, and preserve for posterity the spoken heritage Russian still used today in Brazil by approximately 1,500 elderly bilingual heritage Russian–Brazilian Portuguese speakers. Their unique 100-year-old variety of moribund Russian is disappearing because it has not been passed to their descendants born in Brazil. During the COVID-19 pandemic, we remotely collected 170 h of speech samples in heritage Russian from 26 participants (Mage = 75.7 years) in naturalistic settings using Zoom or a phone call. To estimate the quality of collected data, we focus on two methodological challenges, automatic transcription and acoustic quality of remote recordings. First, we find that among commercially available transcription programs, Sonix far outperforms Google Transcribe and Vocalmatic on the measure of word error rate (WER). Second, we also establish that the acoustic quality of the remote recordings was adequate for intonational and speech rate analysis. Moreover, this remote method of collecting and analyzing speech samples works successfully with elderly bilingual participants who speak a heritage language different from their dominant societal language, and it can become a new norm when face-to-face communication with elderly participants is not possible

Refinement of Animal Experiments: Replacing Traumatic Methods of Laboratory Animal Marking with Non-Invasive Alternatives

Reliable methods for identifying rodents play an important role in ensuring the success of preclinical studies. However, animal identification remains a trivial laboratory routine that is not often discussed, despite the fact that more than 6 million rodents are used in animal studies each year. Currently, there are extensive regulations in place to ensure adequate anesthesia and to reduce animal suffering during experiments. At the same time, not enough attention is paid to the comfort of rodents during routine identification procedures, which can be painful and cause some complications. In order to achieve the highest ethical standards in laboratory research, we must minimize animal discomfort during the identification phase. In this article, we discuss traumatic methods of identification and describe several painless methods for marking in long-term experimental studies. The use of non-traumatic and non-invasive methods requires the renewal of marks as they fade and additional handling of the rodents. Laboratory personnel must be trained in stress-minimizing handling techniques to make mark renewal less stressful