Studying Conceptual Models for Publishing Library Data to the Semantic Web

This thesis studies the library data and the way that linked data technologies may affect libraries. The thesis aims to contribute to the research regarding the devel-opment and implementation of a framework for the integration of bibliographic data in the semantic web. It seeks to make sound propositions for the interopera-bility of conceptual bibliographic models, as well as for future library systems and search environments integrating bibliographic information

Distribution of the surface energy budget: Preliminary analysis on the incoming solar radiation. the case study of the Forni Glacier (Italy)

This study represents a contribution to distribution of the surface energy budget of the Forni Glacier (Ortles-Cevedale Group, Upper Valtellina, Italy). The analyses are based on data acquired at S. Caterina Valfurva (a village in the glacier valley at 1768 m ellipsoidal elevation WGS84) by an Automatic Weather Station (AWS) installed and managed by the Lombardy Agency for the Environment ("ARPA Lombardia"). We focus on the two most important meteorological parameters affecting surface energy budget: air temperature (T) and incoming shortwave radiation (SWin). Data collected from the ARPA AWS are used to evaluate these parameters at the glacier surface during the meteorological summer 2009 (from 1st June to 31st August 2009) and then the computations are validated through comparison with data recorded by an AWS installed at the surface of Forni Glacier tongue ("AWS1 Forni", 2669 m ellipsoidal elevation WGS84). The analysis of the distributed air temperature data enabled identification of the lowest value (-11.9 degrees C), found at the Mount S. Matteo peak (3669 m) on 22nd June at 8: 00 pm, and the highest value (+16.1 degrees C), recorded at the glacier terminus (2497 m) on 23 rd July at 2: 00 pm. The seasonal temperature amplitude (Tmax-Tmin) was 28 degrees C. The hottest week was 20th-26th July 2009 and the coldest was 1st-7th June 2009. Regarding daily SWin distribution, the maximum value (406.9 Wm(-2)) was recorded on 13th June and the minimum (28.5 Wm(-2)) on 6th June. From the analysis of hourly SWin values we could distinguish between days with clear sky conditions and days with intense cloud cover. Weekly mean SWin data showed the greatest value (327.1 Wm(-2)) from 20th-26th July 2009 and the lowest (207.8 Wm(-2)) from 22nd-28th June 2009. Furthermore, in analysing SWin it is critical to take into account the problem of shading. Using the Hillshade tool of ArcGIS, which takes into account only the slope and the aspect of each grid cell neglecting the surrounding topography effect, we compiled 66 shadow maps. Finally this study represents a first approach in modelling the distributed incoming solar radiation. In fact the considered driving factors are the elevation, the slope and the aspect of each grid cell. The next step will consist in taking into account the surrounding topography and the actual atmosphere conditions as well

Preserving Bibliographic Relationships in Mappings from FRBR to BIBFRAME 2.0

In the environment of the World Wide Web large volumes of library data have been pub-lished following different conceptual models. The navigation through these volumes and the data interlinking require the development of mappings between the conceptual models. Library conceptual models provide constructs for the representation of bibliographic families and the relationships between Works. A key requirement for successful map-pings between different conceptual models is to preserve such content relationships. This paper studies a set of cases (Work with single Expression, Work with multiple Expres-sions, translation, adaptation) to examine if and how bibliographic content relationships and families could be preserved in mappings from FRBR to BIBFRAME 2.0. Even though, relationships between Works of the same bibliographic family may be preserved, the progenitor Work is not always represented in BIBFRAME after mappings

2008-2011 snow covered area (SCA) variability over 18 watersheds of the central Chile through MODIS data

Snowmelt contributes largely to water budget of several Chilean mountain watersheds. To describe snow covered area (SCA) variability within 18 watersheds in Central Chile during 2008\u20132011 we used MODIS data (i.e. MOD10A2-V5 maximum snow cover extent in eight-day periods). The study area was divided into three different zones (Northern, Central, and Southern), due to its large extent (~205,000 km2), and according to former studies performed by the Direcc\uedon General de Aguas (DGA) of the Chilean Government covering the time window 2000\u20132007. After georeferencing our data to the WGS84 Datum (UTM Projection, zone 19S), the scenes were cropped to fit the study area. We selected and set a threshold for cloud coverage (<30%) in order to discard the images with too cloud cover, so losing only 2% of the sample. Hypsographic and aspect analyses were performed using the SRTM3 elevation model. We found largest values of SCA during 2008\u20132011 in the Central Zone, while the topographic and climatic features (i.e. lower altitudes in the South, and a drier climate in the North) limit snow deposition elsewhere. Similarly, snow line is higher in the Northern zone (due to the presence of the plateau), and lower moving southwards. In the North the minimum SCA is reached sooner than elsewhere, lasting for a longer period (November to March). West side showed the maximum of SCA in all zones throughout the study period. The present work extends in time the dataset of SCA in the Central Chile, adding information for statistic assessment, and trend analysis of snow cover in this area

Debris cover and surface melt at a temperate maritime alpine glacier: Franz Josef Glacier, New Zealand

Melt rates on glaciers are strongly influenced by the presence of supraglacial debris, which can either enhance or reduce ablation relative to bare ice. Most recently, Franz Josef Glacier has entered into a phase of strong retreat and downwasting, with the increasing emergence of debris on the surface in the ablation zone. Previously at Franz Josef Glacier, melt has only been measured on bare ice. During February 2012, a network of 11 ablation stakes was drilled into locations of varying supraglacial debris thickness on the lower glacier. Mean ablation rates over 9 days varied over the range 1.2–10.1 cm d−1, and were closely related to debris thickness. Concomitant observations of air temperature allowed the application of a degree-day approach to the calculation of melt rates, with air temperature providing a strong indicator of melt. Degree-day factors (d f) varied over the range 1.1–8.1 mm d−1 °C−1 (mean of 4.4 mm d−1 °C−1), comparable with rates reported in other studies. Mapping of the current debris cover revealed 0.7 km2 of the 4.9 km2 ablation zone surface was debris-covered, with thicknesses ranging 1–50 cm. Based on measured debris thicknesses and d f, ablation on debris-covered areas of the glacier is reduced by a total of 41% which equates to a 6% reduction in melt overall across the entire ablation zone. This study highlights the usefulness of a short-term survey to gather representative ablation data, consistent with numerous overseas ablation studies on debris-covered glaciers

Restriction landmark genomic scanning (RLGS) spot identification by second generation virtual RLGS in multiple genomes with multiple enzyme combinations.

BackgroundRestriction landmark genomic scanning (RLGS) is one of the most successfully applied methods for the identification of aberrant CpG island hypermethylation in cancer, as well as the identification of tissue specific methylation of CpG islands. However, a limitation to the utility of this method has been the ability to assign specific genomic sequences to RLGS spots, a process commonly referred to as "RLGS spot cloning."ResultsWe report the development of a virtual RLGS method (vRLGS) that allows for RLGS spot identification in any sequenced genome and with any enzyme combination. We report significant improvements in predicting DNA fragment migration patterns by incorporating sequence information into the migration models, and demonstrate a median Euclidian distance between actual and predicted spot migration of 0.18 centimeters for the most complex human RLGS pattern. We report the confirmed identification of 795 human and 530 mouse RLGS spots for the most commonly used enzyme combinations. We also developed a method to filter the virtual spots to reduce the number of extra spots seen on a virtual profile for both the mouse and human genomes. We demonstrate use of this filter to simplify spot cloning and to assist in the identification of spots exhibiting tissue-specific methylation.ConclusionThe new vRLGS system reported here is highly robust for the identification of novel RLGS spots. The migration models developed are not specific to the genome being studied or the enzyme combination being used, making this tool broadly applicable. The identification of hundreds of mouse and human RLGS spot loci confirms the strong bias of RLGS studies to focus on CpG islands and provides a valuable resource to rapidly study their methylation

Airborne Radio Echo Sounding (RES) measures on Alpine Glaciers to evaluate ice thickness and bedrock geometry: preliminary results from pilot tests performed in the Ortles Cevedale Group (Italian Alps)

Radar exploration supports glaciological studies playing several roles in ice exploration such as determining ice thickness and volume, describing ice and snow internal layering and characterizing crevassed areas. The method, widely used with full success on Polar areas, encounters more difficulties when applied to survey mountain glaciers like the Alpine and Himalayan ones. Among them, these difficulties can be addressed to the different physical characteristics of temperate ice and to logistic difficulties related to performing field operations at high elevations on areas where crevasses, seracs and ice-falls are present, making more complicate and complex the glacier surface. In the framework of the SHARE-PAPRIKA and the SHARE-STELVIO Projects, we performed some preliminary measurements on Careser, Sforzellina and Forni glaciers (Ortles-Cevedale Group, Italy), to evaluate efficiency and applicability of a Radio Echo Sounding (RES) instrument specifically designed, developed and modified by the INGV (Istituto Nazionale di Geofisica e Vulcanologia) laboratories. This paper reports the results we obtained investigating each glacier, the hampering factors and the cost to benefit ratio introduced by the airborne survey

Reviewing, indicating, and counting books for modern research evaluation systems

In this chapter, we focus on the specialists who have helped to improve the conditions for book assessments in research evaluation exercises, with empirically based data and insights supporting their greater integration. Our review highlights the research carried out by four types of expert communities, referred to as the monitors, the subject classifiers, the indexers and the indicator constructionists. Many challenges lie ahead for scholars affiliated with these communities, particularly the latter three. By acknowledging their unique, yet interrelated roles, we show where the greatest potential is for both quantitative and qualitative indicator advancements in book-inclusive evaluation systems.Comment: Forthcoming in Glanzel, W., Moed, H.F., Schmoch U., Thelwall, M. (2018). Springer Handbook of Science and Technology Indicators. Springer Some corrections made in subsection 'Publisher prestige or quality

Identification of the Transgenic Integration Site in Immunodeficient tgε26 Human CD3ε Transgenic Mice

A strain of human CD3ε transgenic mice, tgε26, exhibits severe immunodeficiency associated with early arrest of T cell development. Complete loss of T cells is observed in homozygous tgε26 mice, but not in heterozygotes, suggesting that genomic disruption due to transgenic integration may contribute to the arrest of T cell development. Here we report the identification of the transgenic integration site in tgε26 mice. We found that multiple copies of the human CD3ε transgene are inserted between the Sstr5 and Metrn loci on chromosome 17, and that this is accompanied by duplication of the neighboring genomic region spanning 323 kb. However, none of the genes in this region were abrogated. These results suggest that the severe immunodeficiency seen in tgε26 mice is not due to gene disruption resulting from transgenic integration

Promoter Methylation in Head and Neck Squamous Cell Carcinoma Cell Lines Is Significantly Different than Methylation in Primary Tumors and Xenografts

Studies designed to identify novel methylation events related to cancer often employ cancer cell lines in the discovery phase of the experiments and have a relatively low rate of discovery of cancer-related methylation events. An alternative algorithm for discovery of novel methylation in cancer uses primary tumor-derived xenografts instead of cell lines as the primary source of nucleic acid for evaluation. We evaluated DNA extracted from primary head and neck squamous cell carcinomas (HNSCC), xenografts grown from these primary tumors in nude mice, HNSCC-derived cell lines, normal oral mucosal samples, and minimally transformed oral keratinocyte-derived cell lines using Illumina Infinum Humanmethylation 27 genome-wide methylation microarrays. We found >2,200 statistically significant methylation differences between cancer cell lines and primary tumors and when comparing normal oral mucosa to keratinocyte cell lines. We found no statistically significant promoter methylation differences between primary tumor xenografts and primary tumors. This study demonstrates that tumor-derived xenografts are highly accurate representations of promoter methylation in primary tumors and that cancer derived cell lines have significant drawbacks for discovery of promoter methylation alterations in primary tumors. These findings also support use of primary tumor xenografts for the study of methylation in cancer, drug discovery, and the development of personalized cancer treatments