Low Progesterone and Low Estradiol Levels Associate with Abdominal Aortic Aneurysms in Men

Context Male sex is a major risk factor for abdominal aortic aneurysms (AAA) but few studies have addressed associations between sex hormone levels and AAA.ObjectiveTo describe the associations between serum sex steroids and early, screening-detected AAA in men.MethodsWe validated a high-sensitivity liquid chromatography-tandem mass spectrometry assay for comprehensive serum sex hormone profiling. This assay was then employed in a case-control study including 147 men with AAA (infrarenal aorta ≥30 mm) and 251 AAA-free controls recruited at the general population-based ultrasound screening for AAA in 65-year-old Swedish men.Outcomes includedAssociations between dehydroepiandrosterone, progesterone, 17α-hydroxyprogesterone, androstenedione, estrone, testosterone, dihydrotestosterone, and estradiol and AAA presence.ResultsDehydroepiandrosterone, progesterone, 17α-hydroxyprogesterone, testosterone, and estradiol, but not the other hormones, were lower in men with AAA. In models with adjustments for known AAA risk factors and comorbidity, only progesterone (odds ratio per SD decrease 1.62 [95% CI 1.18-2.22]) and estradiol (1.40 [95% CI 1.04-1.87]) remained inversely associated with the presence of AAA. Progesterone and estradiol contributed with independent additive information for prediction of AAA presence; compared with men with high (above median) levels, men with low (below median) levels of both hormones had a 4-fold increased odds ratio for AAA (4.06 [95% CI 2.25-7.31]).​​​​​​​ConclusionMeasured by a high-performance sex steroid assay, progesterone and estradiol are inversely associated with AAA in men, independently of known risk factors. Future studies should explore whether progesterone and estradiol, which are important reproductive hormones in women, are protective in human AAA.</p

Abdominal Aortic Aneurysm, aspects on diagnosis and treatment

Background An abdominal aortic aneurysm (AAA) is an abnormal widening of the aorta with a risk of rupture if it grows to a large diameter. Rupture is associated with massive bleeding and a poor prognosis for survival. Aims The aim of this thesis was to evaluate the results of surgical intervention in patients with AAAs detected by population-based screening, including comparisons with the results in patients with aneurysms that were not detected by screening. A further aim was to investigate how common misdiagnosis is in the emergency department in patients seeking care for a ruptured AAA (rAAA), and how misdiagnosis affects the prognosis. A third aim was to investigate whether it is beneficial to treat patients with a primary open abdomen with delayed closure after open repair for rAAA. Methods Patients with AAA were identified in the Swedish Vascular Registry (Studies 1‒4) and the Swedish Cause of Death Registry (Study 4). Additional information was obtained through review of medical charts (Studies 2‒4). In Study 1, mortality, complications, and method of surgical intervention were compared in patients with AAAs detected by screening and in age-matched controls with AAAs that were not detected by screening. In Study 2 and Study 4, the outcome in patients with a ruptured abdominal aortic aneurysm (rAAA) who were misdiagnosed at the first assessment in the emergency department was compared to the outcome in patients who were correctly diagnosed initially. Study 2 included patients who reached surgery and Study 4 included all patients with rAAA, whether or not they reached surgery. In Study 3, mortality and complications in patients treated with a primary open abdomen after open repair for rAAA were compared to a propensity score-matched control group in which the majority of patients had the abdomen closed at the end of the procedure. Results Study 1: A higher proportion of the screening-detected patients were treated with open repair (56% vs. 45% in those with AAAs not detected by screening). The mortality 30 days, 90 days, and 1 year after open repair was similar in patients with screening detected and non screeningdetected aneurysms. Mortality at 30 days and 1 year after Endovascular Aortic Repair (EVAR) was similar in both groups. Mortality at 90 days after EVAR was lower in the screening-detected compared to the non screening-detected patients (0% vs. 3.1%; p = 0.04). The overall 30-day mortality (including patients treated with either open repair or EVAR) was 0.6% in screening-detected patients and 1.4% in non screeningdetected patients. (p = 0.45). The adjusted odds ratio for the primary endpoint (mortality or major complication at 30 days) was 1.64 (95% CI 0.82‒3.25) in non screening-detected patients. Studies 2 and 4: Misdiagnosis was common and occurred in more than one-third of the patients with rAAA. Overall, the mortality was 74.6% in misdiagnosed patients and 62.9% in correctly diagnosed patients (p = 0.01). The adjusted odds ratio for mortality in the whole cohort of misdiagnosed patients was 1.83 (1.13‒2.96). In patients who reached surgery, there was no significant difference in mortality between misdiagnosed patients and correctly diagnosed patients. Study 3: There were no significant differences in mortality or major complications between patients treated with a primary open abdomen with delayed closure and patients treated with primary closure of the abdomen. Conclusion The contemporary mortality after AAA surgery in Sweden was low irrespective of whether or not screening was used for detection. Patients with AAAs detected by screening had the same comorbidities and outcome as those with non screening-detected aneurysms, except for 90- day mortality after EVAR, which was lower in the screening group. Misdiagnosis is common in patients who seek care for a rAAA, and misdiagnosis is associated with a substantially higher risk of dying from the ruptured aneurysm. No survival advantage and no lower frequency of complications was observed in patients treated with a primary open abdomen and delayed closure after open repair for rAAA as compared to a propensity score-matched control group where the majority of patients were treated with primary closure of the abdomen

Routine open abdomen treatment compared with on-demand open abdomen or direct closure following open repair of ruptured abdominal aortic aneurysms: A propensity score–matched study

Objective: To investigate whether a strategy of treatment with a primarily open abdomen improves outcome in terms of mortality and major complications in patients treated with open repair for a ruptured abdominal aortic aneurysm compared to a strategy of primary closure of the abdomen. Design: Retrospective cohort study. Methods: Patients treated with a primarily open abdomen at a centre where this strategy was routine in most ruptured abdominal aortic aneurysm patients were compared to a propensity score–matched control group of patients who had the abdomen closed at the end of the primary operation in a majority of the cases. Results: In total, 79 patients treated with a primarily open abdomen after open repair for ruptured abdominal aortic aneurysm at Sahlgrenska University Hospital were compared to a propensity score–matched control group of 148 patients. The abdomen was closed at the end of the procedure in 108 (73%) of the control patients. There was no difference in 30-day mortality between patients treated with a primarily open abdomen at Sahlgrenska University Hospital and the controls, 21 (26.6%) versus 49 (33.1%), p = 0.37. The adjusted odds ratio for mortality at 30 days was 0.66 (95% confidence interval: 0.35–1.25) in patients treated with a primarily open abdomen at Sahlgrenska University Hospital compared to the controls. No difference was observed between the groups regarding 90-day mortality, postoperative renal failure requiring renal replacement therapy, postoperative intestinal ischaemia necessitating bowel resection or postoperative bleeding requiring reoperation. Conclusions: The study did not show any survival advantage or difference in major complications between patients treated with a primarily open abdomen after open repair for ruptured abdominal aortic aneurysm and propensity-matched controls where the abdomen was primarily closed in a majority of the cases