5 research outputs found
Extinction threat of Butia yatay palm groves as a result of the progress of forestry activities at Colonia Pando (San Roque, Corrientes)
La transformación de paisajes naturales en Sudamérica surge como consecuencia del desarrollo humano, relacionado al crecimiento espacial de las ciudades o a la expansión agrícola, ya que ambas implican grandes superficies del territorio y más aún cuando los mismos se encuentran en constante crecimiento. En la provincia de Corrientes, la forestación de Pinus sp. y Eucaliptus sp. es en la actualidad la actividad económica de mayor desarrollo espacial sobre un paisaje local de lomadas arenosas. No obstante, si bien el crecimiento es sumamente significativo, existen muy pocos antecedentes de cómo la actividad forestal impacta sobre este paisaje, principalmente sobre especies autóctonas como los palmares de Butia yatay (Mart.) Becc. En este marco, el objetivo de este trabajo es dar a conocer cómo la expansión de la deforestación pone en riesgo los palmares naturales de Butia yatay, potenciando su extinción si no se regula esta actividad y se protegen especies en peligro. En este trabajo se propone enfatizar los estudios referidos al avance de la actividad forestal, dejando como antecedente la pérdida de uno de los principales componentes fitogeográficos del paisaje.Landscape transformation of natural landscapes in South America rise up as a consequence of human development, related to the spatial growth of cities or agricultural expansion, since both involve large areas of the territory and even more so when they are constantly growing. In the Corrientes province, Eucalyptus and Pinus forestry. is at the present the economic activity with the greatest spatial development over a local landscape of sandy hills. Although the growth is extremely significant, there is very little previous on how forest activity impacts on this landscape, principally on native species such as the palms groves of Butia yatay (Mart.) Becc. In this context, the aim of this paper is to know how the expansion of forestry activity place the natural palm groves of Butia yatay at significant risk. This activity may bring them to extinction if this activity is not regulated and endangered species are not protected. In this paper it is proposed to emphasize the studies referring to the advancement of forestry activity, leaving as a precedent the loss of one of the main phytogeographic components of the landscape.Fil: Contreras, Félix Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Centro de Ecología Aplicada del Litoral. Universidad Nacional del Nordeste. Centro de Ecología Aplicada del Litoral; Argentina. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas y Naturales y Agrimensura; ArgentinaFil: Baruzzo, Mariana Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Centro de Ecología Aplicada del Litoral. Universidad Nacional del Nordeste. Centro de Ecología Aplicada del Litoral; ArgentinaFil: Smichowski, Humberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Centro de Ecología Aplicada del Litoral. Universidad Nacional del Nordeste. Centro de Ecología Aplicada del Litoral; ArgentinaFil: Milano, Micaela. Universidad Autónoma de Entre Ríos; ArgentinaFil: Contreras, Silvina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Centro de Ecología Aplicada del Litoral. Universidad Nacional del Nordeste. Centro de Ecología Aplicada del Litoral; Argentina. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas y Naturales y Agrimensura; Argentin
Metalloproteomics analysis in human mammary cell lines treated with inorganic mercury
The interest in inorganic Hg toxicity and carcinogenicity has been pointed to target organs such as kidney, brain or placenta, but only a few studies have focused on the mammary gland. In this work, analytical combination techniques (SDS-PAGE followed by CV-AFS, and nanoUPLC-ESI-MS/MS) were used to determine proteins that could bind Hg in three human mammary cell lines. Two of them were tumorigenic (MCF-7 and MDA-MB-231) and the other one was the non-tumorigenic cell line (MCF-10A). There are no studies that provide this kind of information in breast cell lines with IHg treatment. Previously, we described the viability, uptake and the subcellular distribution of Hg in human breast cells and analysis of RNA-seq about the genes that encode proteins which are related to cytotoxicity of Hg. This work provides important protein candidates for further studies of Hg toxicity in the mammary gland, thus expanding our understanding of how environmental contaminants might affect tumor progression and contribute with future therapeutic methods.Fil: Ávila Maniero, Mariángeles. Universidad "Juan Agustín Maza"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Interdisciplinario de Ciencias Básicas. - Universidad Nacional de Cuyo. Instituto Interdisciplinario de Ciencias Básicas; ArgentinaFil: Wuilloud, Rodolfo German. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Interdisciplinario de Ciencias Básicas. - Universidad Nacional de Cuyo. Instituto Interdisciplinario de Ciencias Básicas; ArgentinaFil: Callegari, Eduardo Alberto. University of South Dakota; Estados UnidosFil: Smichowski, Patricia Nora. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; ArgentinaFil: Fanelli, Mariel Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentin
Atmospheric stability of arsines and the determination of their oxidative
Biovolatilisation of arsenic as their arsines in the form of AsH 3, and mono-, di and trimethylarsine has often been determined under laboratory conditions. Although environmental point sources such as landfill sites or hot springs have been characterised, only limited knowledge is available on how widespread the formation of volatile methylated arsenic compounds are in the environment. Here we studied the atmospheric stability of the different arsines and quantified their oxidation products in atmospheric particulate matter (PM10) in two locations in Argentina. The atmospheric half-life of the arsines range from 19 weeks for AsH3 to 2 d for trimethylarsine (TMAs) at 20 °C in the dark, while during simulated daytime conditions the stability is reduced for all arsines and in particular for the methylated arsines by three orders of magnitude which suggests that TMAs can only be dispersed at night. At both locations the arsenic concentration was in all samples below 1 ng As m-3, which is considered as rural background for arsenic. The oxidation products, i.e. methylarsonate (MA), dimethylarsinate (DMA) and trimethylarsine oxide (TMAO) were identified by using HPLC-ICP-MS/ES-MS in more than 90% of the 49 PM10 samples taken from 8 sampling points at the two geographically different locations. TMAO was the predominate organoarsenicals in both locations (66 and 69%, respectively) while DMA was determined to be between 13 and 19% of all organoarsenicals at the two locations. The concentration of the organoarsenicals ranged from 4 to 60 pg As as TMAO m-3, while the maximum concentration for DMA and MA were 16 and 6 pg As m-3, respectively. No difference in terms of the concentration or distribution of the organoarsenicals in the PM10 samples was identified as significant. Since the two locations were different in climate and industrial impact and sampled in different seasons, these data suggest that methylated arsenicals do occur as background chemicals in the environment. Due to the low atmospheric stability of the methylated arsines, it is suggested that biovolatilization of arsenic as methylated arsines is a widespread phenomenon. More studies however are necessary to identify the major sources and determine the flux of the volatilization process in order to determine whether or not the process has environmental significance.Fil: Jakob, Ronit. University of Aberdeen; Reino UnidoFil: Roth, Anja. University of Aberdeen; Reino UnidoFil: Haas, Karsten. University of Aberdeen; Reino UnidoFil: Krupp, Eva M.. University of Aberdeen; Reino UnidoFil: Raab, Andrea. University of Aberdeen; Reino UnidoFil: Smichowski, Patricia Nora. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gomez, Dario Gustavo. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Feldmann, Jörg. University of Aberdeen; Reino Unid
Changing rate of serious infections in biologic-exposed rheumatoid arthritis patients : data from South American registries BIOBADABRASIL and BIOBADASAR
Most reports on serious infections (SI) in rheumatoid arthritis (RA) patients treated with biological disease-modifying antirheumatic drugs (bDMARDs) are from the USA and Western Europe. Data from other regions are largely missing. We report data from South American countries with different backgrounds and health-care systems but similar registries. We merged 2010-2016 data from two registries, BIOBADABRASIL (Brazil) and BIOBADASAR (Argentina), which share the same protocol, online platform and data monitoring process. Patients with active RA were included when they began the first bDMARD or a conventional synthetic DMARD (csDMARD, control group). The SI incidence rate (IR) per 1000 patient/years and adjusted IR ratio (aIRR) were estimated for bDMARDs and csDMARDs. Data were analysed for 3717 RA patients with an exposure of 13,380 patient/years. The 2591 patients treated with bDMARDs (64% tumour necrosis factor-alpha inhibitors (TNFi)) had a follow-up of 9300years, and the 1126 treated with csDMARDs had an exposure of 4081 patient/years. The SI IR was 30.54 (CI 27.18-34.30) for all bDMARDs and 5.15 (CI 3.36-7.89) for csDMARDs. The aIRR between the two groups was 2.03 ([1.05, 3.9] p=0.034) for the first 6months of treatment but subsequently increased to 8.26 ([4.32, 15.76] p<0.001). The SI IR for bDMARDs decreased over time in both registries, dropping from 36.59 (28.41-47.12) in 2012 to 7.27 (4.79-11.05) in 2016. While SI remains a major concern in South American patients with RA treated with bDMARDs, a favourable trend toward a reduction was observed in the last years3882129213