Spectroscopically resolving the Algol triple system

Algol (β Persei) is the prototypical semidetached eclipsing binary and a hierarchical triple system. From 2006 to 2010 we obtained 121 high-resolution and high signal-to-noise ratio échelle spectra of this object. Spectral disentangling yields the individual spectra of all three stars, and greatly improved elements both the inner and outer orbits. We find masses of M_A = 3.39 ± 0.06 M⊙, M_B = 0.770 ± 0.009 M⊙ and M_C = 1.58 ± 0.09 M⊙. The disentangled spectra also give the light ratios between the components in the B and V bands. Atmospheric parameters for the three stars are determined, including detailed elemental abundances for Algol A and Algol C. We find the following effective temperatures: T_A = 12 550 ± 120 K, T_B = 4900 ± 300 K and T_C = 7550 ± 250 K. The projected rotational velocities are v_A sin i_A = 50.8 ± 0.8  km/s, v_B sin i_B = 62 ± 2 km/s and v_C sin i_C = 12.4 ± 0.6 km/s. This is the first measurement of the rotational velocity for Algol B, and confirms that it is synchronous with the orbital motion. The abundance patterns of components A and C are identical to within the measurement errors, and are basically solar. They can be summarized as mean metal abundances: [M/H]_A = −0.03 ± 0.08 and [M/H]_C = 0.04 ± 0.09. A carbon deficiency is confirmed for Algol A, with tentative indications for a slight overabundance of nitrogen. The ratio of their abundances is (C/N)_A = 2.0 ± 0.4, half of the solar value of (C/N)⊙ = 4.0 ± 0.7. The new results derived in this study, including detailed abundances and metallicities, will enable tight constraints on theoretical evolutionary models for this complex system

Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7×10-8, HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4×10-8, HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4×10-8, HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific associat

Potential role for Streptococcus gordonii-derived hydrogen peroxide in heme acquisition by Porphyromonas gingivalis

Streptococcus gordonii, an accessory pathogen and early colonizer of plaque, co‐aggregates with many oral species including Porphyromonas gingivalis. It causes α‐hemolysis on blood agar, a process mediated by H2O2 and thought to involve concomitant oxidation of hemoglobin (Hb). Porphyromonas gingivalis has a growth requirement for heme, which is acquired mainly from Hb. The paradigm for Hb heme acquisition involves the initial oxidation of oxyhemoglobin (oxyHb) to methemoglobin (metHb), followed by heme release and extraction through the actions of K‐gingipain protease and/or the HmuY hemophore‐like protein. The ability of S. gordonii to mediate Hb oxidation may potentially aid heme capture during co‐aggregation with P. gingivalis. Hemoglobin derived from zones of S. gordonii α‐hemolysis was found to be metHb. Generation of metHb from oxyHb by S. gordonii cells was inhibited by catalase, and correlated with levels of cellular H2O2 production. Generation of metHb by S. gordonii occurred through the higher Hb oxidation state of ferrylhemoglobin. Heme complexation by the P. gingivalis HmuY was employed as a measure of the ease of heme capture from metHb. HmuY was able to extract iron(III)protoporphyrin IX from metHb derived from zones of S. gordonii α‐hemolysis and from metHb generated by the action of S. gordonii cells on isolated oxyHb. The rate of HmuY‐Fe(III)heme complex formation from S. gordonii‐mediated metHb was greater than from an equivalent concentration of auto‐oxidized metHb. It is concluded that S. gordonii may potentially aid heme acquisition by P. gingivalis by facilitating metHb formation in the presence of oxyHb

Structure-dependent hydrostatic deformation potentials of individual single-walled carbon nanotubes

Summary: The hydrostatic pressure coefficients of interband transition energies of a number of single-walled carbon nanotubes with different chiralities were measured. Both optical absorption and photoluminescence experiments were performed on de-bundled, single-walled carbon nanotube suspensions with hydrostatic pressure applied by diamond anvil cells. The pressure coefficients of the first van Hove transition (bandgap) energies are negative and dependent on the nanotube structure, while the second van Hove transitions are much less sensitive to hydrostatic pressure. The hydrostatic deformation potentials of individual nanotubes are deduced within an elastic model. An empirical equation that relates the pressure coefficients to nanotube structure is presented and discussed