Ki67 expression levels are a better marker of reduced melanoma growth following MEK inhibitor treatment than phospho-ERK levels

The loss of tumour phospho-extracellular responsive kinase (pERK) positivity is the major treatment biomarker for mitogen-activated protein kinase/extracellular responsive kinase (MEK) inhibitors. Here, we demonstrate that there is a poor correlation between pERK inhibition and the anti-proliferative effects of MEK inhibitors in melanoma cells. We suggest that Ki67 is a better biomarker for future clinical studies

Perfect hypermomentum fluid: variational theory and equations of motion

The variational theory of the perfect hypermomentum fluid is developed. The new type of the generalized Frenkel condition is considered. The Lagrangian density of such fluid is stated, and the equations of motion of the fluid and the Weyssenhoff-type evolution equation of the hypermomentum tensor are derived. The expressions of the matter currents of the fluid (the canonical energy-momentum 3-form, the metric stress-energy 4-form and the hypermomentum 3-form) are obtained. The Euler-type hydrodynamic equation of motion of the perfect hypermomentum fluid is derived. It is proved that the motion of the perfect fluid without hypermomentum in a metric-affine space coincides with the motion of this fluid in a Riemann space.Comment: REVTEX, 23 pages, no figure

In-Line-Test of Variability and Bit-Error-Rate of HfOx-Based Resistive Memory

Spatial and temporal variability of HfOx-based resistive random access memory (RRAM) are investigated for manufacturing and product designs. Manufacturing variability is characterized at different levels including lots, wafers, and chips. Bit-error-rate (BER) is proposed as a holistic parameter for the write cycle resistance statistics. Using the electrical in-line-test cycle data, a method is developed to derive BERs as functions of the design margin, to provide guidance for technology evaluation and product design. The proposed BER calculation can also be used in the off-line bench test and build-in-self-test (BIST) for adaptive error correction and for the other types of random access memories.Comment: 4 pages. Memory Workshop (IMW), 2015 IEEE Internationa

The reaction of chlorotetrafluorophosphorane with trimethylamine

The reaction of chlorotetrafluorophosphorane with trimethylamine affords a 1:1 Lewis acid-base complex of composition ClF4P[middle dot]NMe3. It has been established by 1H and 19F NMR spectroscopy that the Cl and Me3N ligands occupy mutually trans positions in a locally octahedral geometry around phosphorus.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/23385/1/0000330.pd

Spectral analysis of Kepler SPB and Beta Cep candidate stars

We determine the fundamental parameters of SPB and Beta Cep candidate stars observed by the Kepler satellite mission and estimate the expected types of non-radial pulsators by comparing newly obtained high-resolution spectra with synthetic spectra computed on a grid of stellar parameters assuming LTE and check for NLTE effects for the hottest stars. For comparison, we determine Teff independently from fitting the spectral energy distribution of the stars obtained from the available photometry. We determine Teff, log(g), micro-turbulent velocity, vsin(i), metallicity, and elemental abundance for 14 of the 16 candidate stars, two of the stars are spectroscopic binaries. No significant influence of NLTE effects on the results could be found. For hot stars, we find systematic deviations of the determined effective temperatures from those given in the Kepler Input Catalogue. The deviations are confirmed by the results obtained from ground-based photometry. Five stars show reduced metallicity, two stars are He-strong, one is He-weak, and one is Si-strong. Two of the stars could be Beta Cep/SPB hybrid pulsators, four SPB pulsators, and five more stars are located close to the borders of the SPB instability region.Comment: 10 pages, 10 figures, 10 table

Self-directed growth of AlGaAs core-shell nanowires for visible light applications

Al(0.37)Ga(0.63)As nanowires (NWs) were grown in a molecular beam epitaxy system on GaAs(111)B substrates. Micro-photoluminescence measurements and energy dispersive X-ray spectroscopy indicated a core-shell structure and Al composition gradient along the NW axis, producing a potential minimum for carrier confinement. The core-shell structure formed during the growth as a consequence of the different Al and Ga adatom diffusion lengths.Comment: 20 pages, 7 figure

Self-affine Asperity Model for earthquakes

A model for fault dynamics consisting of two rough and rigid brownian profiles that slide one over the other is introduced. An earthquake occurs when there is an intersection between the two profiles. The energy release is proportional to the overlap interval. Our model exhibits some specific features which follow from the fractal geometry of the fault: (1) non-universality of the exponent of the Gutenberg-Richter law for the magnitude distribution; (2) presence of local stress accumulation before a large seismic event; (3) non-trivial space-time clustering of the epicenters. These properties are in good agreement with various observations and lead to specific predictions that can be experimentally tested.Comment: TeX file, 14 pages, 3 figures available from [email protected]