Neuromedin U partially mediates leptin-induced hypothalamo-pituitary adrenal (HPA) stimulation and has a physiological role in the regulation of the HPA axis in the rat.

Intracerebroventricular (ICV) administration of the hypothalamic neuropeptide neuromedin U (NMU) or the adipostat hormone leptin increases plasma ACTH and corticosterone. The relationship between leptin and NMU in the regulation of the hypothalamo-pituitary adrenal (HPA) axis is currently unknown. In this study, leptin (1 nM) significantly increased the release of CRH from ex vivo hypothalamic explants by 207 ± 8.4% (P < 0.05 vs. basal), an effect blocked by the administration of anti-NMU IgG. The ICV administration of leptin (10 μg, 0.625 nmol) increased plasma ACTH and corticosterone 20 min after injection [plasma ACTH (picograms per milliliter): vehicle, 63 ± 20, leptin, 135 ± 36, P < 0.05; plasma corticosterone (nanograms per milliliter): vehicle, 285 ± 39, leptin, 452 ± 44, P < 0.01]. These effects were partially attenuated by the prior administration of anti-NMU IgG. Peripheral leptin also stimulated ACTH release, an effect attenuated by prior ICV administration of anti-NMU IgG. We examined the diurnal pattern of hypothalamic NMU mRNA expression and peptide content, plasma leptin, and plasma corticosterone. The diurnal changes in hypothalamic NMU mRNA expression were positively correlated with hypothalamic NMU peptide content, plasma corticosterone, and plasma leptin. The ICV administration of anti-NMU IgG significantly attenuated the dark phase rise in corticosterone [corticosterone (nanograms per milliliter): vehicle, 493 ± 38; NMU IgG, 342 ± 47 (P < 0.05)]. These studies suggest that NMU may play a role in the regulation of the HPA axis and partially mediate leptin-induced HPA stimulation. Copyright © 2006 by The Endocrine Society

Good practice in food-related neuroimaging

The use of neuroimaging tools, especially functional magnetic resonance imaging, in nutritional research has increased substantially over the past 2 decades. Neuroimaging is a research tool with great potential impact on the field of nutrition, but to achieve that potential, appropriate use of techniques and interpretation of neuroimaging results is necessary. In this article, we present guidelines for good methodological practice in functional magnetic resonance imaging studies and flag specific limitations in the hope of helping researchers to make the most of neuroimaging tools and avoid potential pitfalls. We highlight specific considerations for food-related studies, such as how to adjust statistically for common confounders, like, for example, hunger state, menstrual phase, and BMI, as well as how to optimally match different types of food stimuli. Finally, we summarize current research needs and future directions, such as the use of prospective designs and more realistic paradigms for studying eating behavior

The UV-Optical Galaxy Color-Magnitude Diagram. I. Basic Properties

We have analyzed the bivariate distribution of galaxies as a function of ultraviolet-optical colors and absolute magnitudes in the local universe. The sample consists of galaxies with redshifts and optical photometry from the Sloan Digital Sky Survey (SDSS) main galaxy sample matched with detections in the near-ultraviolet (NUV) and far-ultraviolet (FUV) bands in the Medium Imaging Survey being carried out by the Galaxy Evolution Explorer (GALEX) satellite. In the (NUV − r)_(0.1) versus M_(r,0.1) galaxy color-magnitude diagram, the galaxies separate into two well-defined blue and red sequences. The (NUV − r)_(0.1) color distribution at each M_(r,0.1) is not well fit by the sum of two Gaussians due to an excess of galaxies in between the two sequences. The peaks of both sequences become redder with increasing luminosity, with a distinct blue peak visible up to M_(r,0.1) ~ − 23. The r_(0.1)-band luminosity functions vary systematically with color, with the faint-end slope and characteristic luminosity gradually increasing with color. After correcting for attenuation due to dust, we find that approximately one-quarter of the color variation along the blue sequence is due to dust, with the remainder due to star formation history and metallicity. Finally, we present the distribution of galaxies as a function of specific star formation rate and stellar mass. The specific star formation rates imply that galaxies along the blue sequence progress from low-mass galaxies with star formation rates that increase somewhat with time to more massive galaxies with a more or less constant star formation rate. Above a stellar mass of ~10^(10.5) M_☉, galaxies with low ratios of current to past averaged star formation rate begin to dominate

The Young and the Dustless: Interpreting Radio Observations of UltraViolet Luminous Galaxies

Ultraviolet Luminous Galaxies (UVLGs) have been identified as intensely star-forming, nearby galaxies. A subset of these, the supercompact UVLGs, are believed to be local analogs of high redshift Lyman Break Galaxies. Here we investigate the radio continuum properties of this important population for the first time. We have observed 42 supercompact UVLGs with the VLA, all of which have extensive coverage in the UV/optical by GALEX and SDSS. Our analysis includes comparison samples of multiwavelength data from the Spitzer First Look Survey and from the SDSS-Galex matched catalogs. In addition we have Spitzer MIPS data for 24 of our galaxies and find that they fall on the radio-FIR correlation of normal star-forming galaxies. We find that our galaxies have lower radio-to-UV ratios and lower Balmer decrements than other local galaxies with similar (high) star formation rates. Optical spectra show they have lower Dn(4000) and HdeltaA indices, higher Hbeta emission-line equivalents widths, and higher [OIII]5007/Hbeta emission-line ratios than normal star forming galaxies. Comparing these results to galaxy spectral evolution models we conclude that supercompact UVLGs are distinguished from normal star forming galaxies firstly by their high specific star formation rates. Moreover, compared to other types of galaxies with similar star formation rates, they have significantly less dust attenuation. In both regards they are similar to Lyman Break Galaxies. This suggests that the process that causes star formation in the supercompact UVLGs differs from other local star forming galaxies, but may be similar to Lyman Break Galaxies.Comment: 37 pages, 13 figures, accepted and scheduled to appear in ApJS December 2007 (GALEX Special Issue

The Calibration and Data Products of the Galaxy Evolution Explorer

We describe the calibration status and data products pertaining to the GR2 and GR3 data releases of the Galaxy Evolution Explorer (GALEX). These releases have identical pipeline calibrations that are significantly improved over the GR1 data release. GALEX continues to survey the sky in the Far Ultraviolet (FUV, ~154 nm) and Near Ultraviolet (NUV, ~232 nm) bands, providing simultaneous imaging with a pair of photon counting, microchannel plate, delay line readout detectors. These 1.25 degree field-of-view detectors are well-suited to ultraviolet observations because of their excellent red rejection and negligible background. A dithered mode of observing and photon list output pose complex requirements on the data processing pipeline, entangling detector calibrations and aspect reconstruction algorithms. Recent improvements have achieved photometric repeatability of 0.05 and 0.03 mAB in the FUV and NUV, respectively. We have detected a long term drift of order 1% FUV and 6% NUV over the mission. Astrometric precision is of order 0.5" RMS in both bands. In this paper we provide the GALEX user with a broad overview of the calibration issues likely to be confronted in the current release. Improvements are likely as the GALEX mission continues into an extended phase with a healthy instrument, no consumables, and increased opportunities for guest investigations.Comment: Accepted to the ApJS (a special GALEX issue

Ly alpha-emitting galaxies at 0.2 < z < 0.35 from GALEX spectroscopy

We have used the GALEX (Galaxy Evolution Explorer) spectroscopic survey mode, with a resolution of similar to 8 angstrom in the far-ultraviolet (FUV; 1350-1750 angstrom) and similar to 20 angstrom in the near-ultraviolet (NUV; 1950-2750 angstrom) for a systematic search of Ly alpha-emitting galaxies at low redshift. Our aim is to fill a gap between high-redshift surveys and a small set of objects studied in detail in the nearby universe. A blind search of 7018 spectra extracted in five deep exposures (5.65 deg(2)) has resulted in 96 Ly alpha-emitting galaxy candidates in the FUV domain after accounting for broad-line AGNs. The Ly alpha equivalent widths (EWs) are consistent with stellar population model predictions and show no trends as a function of UV color or UV luminosity, with the exception of a possible decrease in the most luminous objects that may be due to small-number statistics. The objects' distribution in EW is similar to that at z similar to 3, but their fraction among star-forming galaxies is smaller. Avoiding uncertain candidates, a subsample of 66 objects in the range 0.2 < z < 0.35 has been used to build a Ly alpha luminosity function (LF). The incompleteness due to objects with significant Ly alpha emission but a UV continuum too low for spectral extraction has been evaluated. A comparison with H alpha LFs in the same redshift domain is consistent with an average Ly alpha/H alpha of similar to 1 in about 15% of the star-forming galaxies. A comparison with high-redshift Ly alpha LFs implies an increase of the Ly alpha luminosity density by a factor of about 16 from z similar to 0.3 to z similar to 3. By comparison with the factor of 5 increase in the UV luminosity density in the same redshift range, this suggests an increase of the average Ly alpha escape fraction with redshift