Age Determination at Death from Osteon Counting by Means of Interactive Computer Graphics

The purpose of this study is to show the feasibility of doing osteon counting on the computer. A sample of 11 specimens were prepared by thin section techniques in order to be photographed through a Reichert transmitted-light interface contrast Zetopan research microscope. After the photographs were mosaiced into a single representative picture of the field of vision, the picture was digitized and processed for age by the computer. Digitizing the specimens is accomplished by the use of interactive computer graphics. Using a tablet with a cursor or pen, the picture is digitized and stored in a file of x and y coordinates on a magnetic disk by the computer. This file of stored data is used in other computer programs to measure dmax, centroid plots, area information on the individual features and calculate age at death for the specimen. Kerley and Ubelaker\u27s (1978) regression formulas were utilized. The major findings of the research concerned percent of circumferential lamellar bone and individual fields of vision. The regression formula for percent of circumferential lamellar bone as determined by the Kerley technique (1965) was not reliable with measured data of the computer. A new regression formula was calculated based on the measured data of the sample with eight out of eleven cases having the age range score bracketing the known age of the specimen. All three cases which were aged incorrectly were within plus or minus 10 years of the actual age. Another finding revealed that one field of vision is not superior to another. Some anthropologists had implied that the posterior field of vision, because of muscle attachment to the linea aspera, would yield faulty scores. My results show that the worst field is the medial view and not the posterior. When comparing individual field statistics to the four field total the results demonstrate that one field may be selected. The resulting age range calculated by the computer is as satisfactory as those age ranges produced from the four field total. Since no special training is required to operate the computer and cost of the equipment is economical, a large group of researchers wanting to do osteon counting could utilize my procedure

Electromyogram (EMG) Removal by Adding Sources of EMG (ERASE) -- A novel ICA-based algorithm for removing myoelectric artifacts from EEG -- Part 2

Extraction of the movement-related high-gamma (80 - 160 Hz) in electroencephalogram (EEG) from traumatic brain injury (TBI) patients who have had hemicraniectomies, remains challenging due to a confounding bandwidth overlap with surface electromyogram (EMG) artifacts related to facial and head movements. In part 1, we described an augmented independent component analysis (ICA) approach for removal of EMG artifacts from EEG, and referred to as EMG Reduction by Adding Sources of EMG (ERASE). Here, we tested ERASE on EEG recorded from six TBI patients with hemicraniectomies while they performed a thumb flexion task. ERASE removed a mean of 52 +/- 12% (mean +/- S.E.M) (maximum 73%) of EMG artifacts. In contrast, conventional ICA removed a mean of 27 +/- 19\% (mean +/- S.E.M) of EMG artifacts from EEG. In particular, high-gamma synchronization was significantly improved in the contralateral hand motor cortex area within the hemicraniectomy site after ERASE was applied. We computed fractal dimension (FD) of EEG high-gamma on each channel. We found relative FD of high-gamma over hemicraniectomy after applying ERASE were strongly correlated to the amplitude of finger flexion force. Results showed that significant correlation coefficients across the electrodes related to thumb flexion averaged 0.76, while the coefficients across the homologous electrodes in non-hemicraniectomy areas were nearly 0. Across all subjects, an average of 83% of electrodes significantly correlated with force was located in the hemicraniectomy areas after applying ERASE. After conventional ICA, only 19% of electrodes with significant correlations were located in the hemicraniectomy. These results indicated that the new approach isolated electrophysiological features during finger motor activation while selectively removing confounding EMG artifacts

Artifactual log-periodicity in finite size data: Relevance for earthquake aftershocks

The recently proposed discrete scale invariance and its associated log-periodicity are an elaboration of the concept of scale invariance in which the system is scale invariant only under powers of specific values of the magnification factor. We report on the discovery of a novel mechanism for such log-periodicity relying solely on the manipulation of data. This ``synthetic'' scenario for log-periodicity relies on two steps: (1) the fact that approximately logarithmic sampling in time corresponds to uniform sampling in the logarithm of time; and (2) a low-pass-filtering step, as occurs in constructing cumulative functions, in maximum likelihood estimations, and in de-trending, reddens the noise and, in a finite sample, creates a maximum in the spectrum leading to a most probable frequency in the logarithm of time. We explore in detail this mechanism and present extensive numerical simulations. We use this insight to analyze the 27 best aftershock sequences studied by Kisslinger and Jones [1991] to search for traces of genuine log-periodic corrections to Omori's law, which states that the earthquake rate decays approximately as the inverse of the time since the last main shock. The observed log-periodicity is shown to almost entirely result from the ``synthetic scenario'' owing to the data analysis. From a statistical point of view, resolving the issue of the possible existence of log-periodicity in aftershocks will be very difficult as Omori's law describes a point process with a uniform sampling in the logarithm of the time. By construction, strong log-periodic fluctuations are thus created by this logarithmic sampling.Comment: LaTeX, JGR preprint with AGU++ v16.b and AGUTeX 5.0, use packages graphicx, psfrag and latexsym, 41 eps figures, 26 pages. In press J. Geophys. Re

Direct Classification of All American English Phonemes Using Signals From Functional Speech Motor Cortex

Although brain-computer interfaces (BCIs) can be used in several different ways to restore communication, communicative BCI has not approached the rate or efficiency of natural human speech. Electrocorticography (ECoG) has precise spatiotemporal resolution that enables recording of brain activity distributed over a wide area of cortex, such as during speech production. In this study, we investigated words that span the entire set of phonemes in the General American accent using ECoG with 4 subjects. We classified phonemes with up to 36% accuracy when classifying all phonemes and up to 63% accuracy for a single phoneme. Further, misclassified phonemes follow articulation organization described in phonology literature, aiding classification of whole words. Precise temporal alignment to phoneme onset was crucial for classification success. We identified specific spatiotemporal features that aid classification, which could guide future applications. Word identification was equivalent to information transfer rates as high as 3.0 bits/s (33.6 words min), supporting pursuit of speech articulation for BCI control

Comparative study of nonlinear properties of EEG signals of a normal person and an epileptic patient

Background: Investigation of the functioning of the brain in living systems has been a major effort amongst scientists and medical practitioners. Amongst the various disorder of the brain, epilepsy has drawn the most attention because this disorder can affect the quality of life of a person. In this paper we have reinvestigated the EEGs for normal and epileptic patients using surrogate analysis, probability distribution function and Hurst exponent. Results: Using random shuffled surrogate analysis, we have obtained some of the nonlinear features that was obtained by Andrzejak \textit{et al.} [Phys Rev E 2001, 64:061907], for the epileptic patients during seizure. Probability distribution function shows that the activity of an epileptic brain is nongaussian in nature. Hurst exponent has been shown to be useful to characterize a normal and an epileptic brain and it shows that the epileptic brain is long term anticorrelated whereas, the normal brain is more or less stochastic. Among all the techniques, used here, Hurst exponent is found very useful for characterization different cases. Conclusions: In this article, differences in characteristics for normal subjects with eyes open and closed, epileptic subjects during seizure and seizure free intervals have been shown mainly using Hurst exponent. The H shows that the brain activity of a normal man is uncorrelated in nature whereas, epileptic brain activity shows long range anticorrelation.Comment: Keywords:EEG, epilepsy, Correlation dimension, Surrogate analysis, Hurst exponent. 9 page

Tunneling Between Parallel Two-Dimensional Electron Gases

The tunneling between two parallel two-dimensional electron gases has been investigated as a function of temperature $T$, carrier density $n$, and the applied perpendicular magnetic field $B$. In zero magnetic field the equilibrium resonant lineshape is Lorentzian, reflecting the Lorentzian form of the spectral functions within each layer. From the width of the tunneling resonance the lifetime of the electrons within a 2DEG has been measured as a function of $n$ and $T$, giving information about the density dependence of the electron-impurity scattering and the temperature dependence of the electron-electron scattering. In a magnetic field there is a general suppression of equilibrium tunneling for fields above $B=0.6$ T. A gap in the tunneling density of states has been measured over a wide range of magnetic fields and filling factors, and various theoretical predictions have been examined. In a strong magnetic field, when there is only one partially filled Landau level in each layer, the temperature dependence of the conductance characteristics has been modeled with a double-Gaussian spectral density.Comment: LaTeX requires REVTeX macros. Eighteen pages. Fourteen postscript figures are included. (All figures have been bitmapped to save space. The original can be requested by email from [email protected]). Accepted for publication in Phys. Rev.

Somatostatin and dopamine receptors as targets for medical treatment of Cushing's Syndrome

Somatostatin (SS) and dopamine (DA) receptors are widely expressed in neuroendocrine tumours that cause Cushing's Syndrome (CS). Increasing knowledge of specific subtype expression within these tumours and the ability to target these receptor subtypes with high-affinity compounds, has driven the search for new SS- or DA-based medical therapies for the various forms of CS. In Cushing's disease, corticotroph adenomas mainly express dopamine receptor subtype 2 (D2) and somatostatin receptor subtype 5 (sst5), whereas sst2is expressed at lower levels. Activation of these receptors can inhibit ACTH-release in primary cultured corticotroph adenomas and compounds that target either sst5(pasireotide, or SOM230) or D2(cabergoline) have shown significant efficacy in subsets of patients in recent clinical studies. Combination therapy, either by administration of both types of compounds separately or by treatment with novel somatostatin-dopamine chimeric molecules (e.g. BIM-23A760), appears to be a promising approach in this respect. In selected cases of Ectopic ACTH-producing Syndrome (EAS), the sst2-preferring compound octreotide is able to reduce cortisol levels effectively. A recent study showed that D2receptors are also significantly expressed in the majority of EAS and that cabergoline may decrease cortisol levels in subsets of these patients. In both normal adrenal tissue as well as in adrenal adenomas and carcinomas that cause CS, sst and DA receptor expression has been demonstrated. Although selected cases of adrenal CS may benefit from sst or DA-targeted treatment, its total contribution to the treatment of these patients is likely to be low as surgery is effective in most cases