Enhancing the Quality of Life of Nursing Home Residents with Late Stage Alzheimer\u27s Disease and Related Disorders

Educational Objectives 1. Discuss the growing need for special programming and activities to improve the quality of life of nursing home residents with dementing illnesses. 2. Discuss program and activity options that have a positive impact on quality of life as measured by the resident\u27s mood, behavioral symptoms, cognitive skills, physical condition and medication use. 3. Review the responses of a resident to our unit’s therapeutic interventions

The invention of an international order: lessons from 1814

In 1814, an alliance of European empires captured Paris and exiled Napoleon Bonaparte. Drawing on a new book, Glenda Sluga explains how this coalition planted the seeds for today’s international order, wedding the idea of a durable peace to multilateralism, diplomacy, philanthropy, and rights, and making Europe its centre

Kinematic Performances Comparisons Between Galileo, GPS And Glonass Satellite Positioning Systems

The initial Galileo satellite positioning services, starting from the 15 December 2016, became available with a formal announcement of the European Commission. This was the first step toward the Galileo system Full Operational Capability (FOC) and allowed many researchers to test the new system. The aim of this paper is to show some results of kinematic tests involving a GNSS multi-constellation receiver able to acquire the Galileo Open Service (OS) signal. The acquired data were compared with the outputs obtained by a Mobile Mapping System (MMS) implementing integrated high-performance GPS/INS measurements. Using GrafNav software version 8.80 all the possible operative combinations were tested and analyzed. The results, referred to the performed experimental test, show that the new European system is characterized by a better planimetric performance with respect to the other systems whereas, from an altimetric point of view, the GPS and Glonass systems perform bette

Heterogeneous computing architecture for fast detection of SNP-SNP interactions

The extent of data in a typical genome-wide association study (GWAS) poses considerable computational challenges to software tools for gene-gene interaction discovery. Exhaustive evaluation of all interactions among hundreds of thousands to millions of single nucleotide polymorphisms (SNPs) may require weeks or even months of computation. Massively parallel hardware within a modern Graphic Processing Unit (GPU) and Many Integrated Core (MIC) coprocessors can shorten the run time considerably. While the utility of GPU-based implementations in bioinformatics has been well studied, MIC architecture has been introduced only recently and may provide a number of comparative advantages that have yet to be explored and tested. We have developed a heterogeneous, GPU and Intel MIC-accelerated software module for SNP-SNP interaction discovery to replace the previously single-threaded computational core in the interactive web-based data exploration program SNPsyn. We report on differences between these two modern massively parallel architectures and their software environments. Their utility resulted in an order of magnitude shorter execution times when compared to the single-threaded CPU implementation. GPU implementation on a single Nvidia Tesla K20 runs twice as fast as that for the MIC architecture-based Xeon Phi P5110 coprocessor, but also requires considerably more programming effort. General purpose GPUs are a mature platform with large amounts of computing power capable of tackling inherently parallel problems, but can prove demanding for the programmer. On the other hand the new MIC architecture, albeit lacking in performance reduces the programming effort and makes it up with a more general architecture suitable for a wider range of problems

Heterogeneous computing architecture for fast detection of SNP-SNP interactions

The extent of data in a typical genome-wide association study (GWAS) poses considerable computational challenges to software tools for gene-gene interaction discovery. Exhaustive evaluation of all interactions among hundreds of thousands to millions of single nucleotide polymorphisms (SNPs) may require weeks or even months of computation. Massively parallel hardware within a modern Graphic Processing Unit (GPU) and Many Integrated Core (MIC) coprocessors can shorten the run time considerably. While the utility of GPU-based implementations in bioinformatics has been well studied, MIC architecture has been introduced only recently and may provide a number of comparative advantages that have yet to be explored and tested. We have developed a heterogeneous, GPU and Intel MIC-accelerated software module for SNP-SNP interaction discovery to replace the previously single-threaded computational core in the interactive web-based data exploration program SNPsyn. We report on differences between these two modern massively parallel architectures and their software environments. Their utility resulted in an order of magnitude shorter execution times when compared to the single-threaded CPU implementation. GPU implementation on a single Nvidia Tesla K20 runs twice as fast as that for the MIC architecture-based Xeon Phi P5110 coprocessor, but also requires considerably more programming effort. General purpose GPUs are a mature platform with large amounts of computing power capable of tackling inherently parallel problems, but can prove demanding for the programmer. On the other hand the new MIC architecture, albeit lacking in performance reduces the programming effort and makes it up with a more general architecture suitable for a wider range of problems

Turning International: Foundations of Modern International Thought and New Paradigms for Intellectual History

This essay provides an overview of the disciplinary and analytical significance of David Armitage's Foundations of Modern International Thought in the context of the new international history, and the so-called ‘international turn’. It then goes on to discuss the significance of the absence of women in this new sub-field of intellectual history

QSPR Models for Prediction of Aqueous Solubility: Exploring the Potency of Randić-type Indices

The development of QSPR models to predict aqueous solubility (logS) is presented. A structurally diverse set of over 1600 compounds with experimentally determined solubility values (AqSolDB database) is used for building the data-driven models based on multiple linear regression (MLR) and artificial neural network (ANN) methods to predict aqueous solubility. Molecular structures are encoded by numerous structural descriptors, including the connectivity index developed by Randić in 1975, and many later derived variations. To evaluate the potency of Randić-like descriptors in the structure-property relationship, we developed models based on two sets of descriptors, first using only Randić-like descriptors calculated with Dragon, and second using 17 commonly applied descriptors available in the AqSolDB database. All models were validated with external prediction sets, with the RMSE ranging from 0.8 to 1.1. Interestingly, the RMSE of predicted LogS values of models based only on the Randić-like descriptors were in average just 0.1 larger than the models with 17 descriptors preselected as suitable for modelling logS. This work is licensed under a Creative Commons Attribution 4.0 International License

Gender, Peace and the New International Politics of Humanitarianism in the First Half of the Twentieth Century

This chapter examines the changing ideas of peace and their connections with the longer history of humanitarianism in the first half of the twentieth century, using gender as an analytical focus. In particular, it explores the international and internationalist contexts of the emerging peace movement and international humanitarianism and their changing character; the gender dimensions of peace-thinking and policies, especially in the context of the League of Nations and the United Nations; and the ways in which feminism was a significant influence on the development of these two international bodies, even as women were sidelined in their operations. In the first half of the twentieth century, these international, intergovernmental organizations had as their central rationale the taming of warfare. The chapter analyzes the extent to which, in each case, they contributed to the institutionalization of new gendered international norms of pacifist and humanitarian activism