Strongly Scale-dependent Non-Gaussianity

We discuss models of primordial density perturbations where the non-Gaussianity is strongly scale-dependent. In particular, the non-Gaussianity may have a sharp cut-off and be very suppressed on large cosmological scales, but sizeable on small scales. This may have an impact on probes of non-Gaussianity in the large-scale structure and in the cosmic microwave background radiation anisotropies.Comment: 4 page

On the one loop corrections to inflation and the CMB anisotropies

We investigate the one loop effective potential of inflation in a standard model of chaotic inflation. The leading one loop corrections to the effective inflaton potential are evaluated in the quasi de Sitter background, and we estimate the one loop correction to the two-point function of the inflaton perturbations in the Hartree approximation. In this approximation, the one loop corrections depends on the total number of e-foldings of inflation and the maximal effect is estimated to be a correction to the power spectrum of a few percent. However, such a correction may be difficult to disentangle from the background in the simplest scenario

de Sitter limit of inflation and nonlinear perturbation theory

We study the fourth order action of the comoving curvature perturbation in an inflationary universe in order to understand more systematically the de Sitter limit in nonlinear cosmological perturbation theory. We derive the action of the curvature perturbation to fourth order in the comoving gauge, and show that it vanishes sufficiently fast in the de Sitter limit. By studying the de Sitter limit, we then extrapolate to the n'th order action of the comoving curvature perturbation and discuss the slow-roll order of the n-point correlation function.Comment: 14 pages, 1 figure; typos corrected and discussion of tensor modes adde

The Matrix Reloaded - on the Dark Energy Seesaw

We propose a novel mechanism for dark energy, based on an extended seesaw for scalar fields, which does not require any new physics at energies below the TeV scale. A very light quintessence mass is usually considered to be technically unnatural, unless it is protected by some symmetry broken at the new very light scale. We propose that one can use an extended seesaw mechanism to construct technically natural models for very light fields, protected by SUSY softly broken above a TeV

Cosmological diagrammatic rules

A simple set of diagrammatic rules is formulated for perturbative evaluation of ``in-in" correlators, as is needed in cosmology and other nonequilibrium problems. These rules are both intuitive, and efficient for calculational purposes.Comment: 7 pages, 3 figure

Extracellular Vesicles:An Important Biomarker in Recurrent Pregnancy Loss?

Recurrent pregnancy loss (RPL) has an estimated incidence of 1–3% of all couples. The etiology is considered to be multifactorial. Extracellular vesicles (EVs) take part in numerous different physiological processes and their contents show the originating cell and pathophysiological states in different diseases. In pregnancy disorders, changes can be seen in the composition, bioactivity and concentration of placental and non-placental EVs. RPL patients have an increased risk of pregnancy complications. The aim of this prospective study was to examine whether measuring different specific EV markers in plasma before and during pregnancy could be used as predictors of pregnancy loss (PL) in women with RPL. Thirty-one RPL patients were included in this study; 25 had a live birth (LB group) and six had a new PL (PL group). Five blood samples were obtained, one before achieved pregnancy and the others in gestational week 6, 8, 10 and 16. Moreover, some of the patients received intravenous immunoglobulin (IVIG) infusions as part of treatment, and it was also examined whether this treatment influenced the EV levels. Seventeen EV markers specific for the immune system, coagulation, placenta and hypoxia were analyzed in the samples with EV Array, a method able to capture small EVs by using an antibody panel targeting membrane proteins. Comparing the LB and PL groups, one EV marker, CD9, showed a significant increase from before pregnancy to gestational week 6 in the PL group. The changes in the other 16 markers were nonsignificant. One case of late-onset PL showed steeply increasing levels, with sudden decrease after gestational week 10 in nine of 17 markers. Moreover, there was an overall increase of all 17 markers after IVIG treatment in the LB group, which was significant in 15 of the markers. Whether increases in EVs positive for CD9 characterize RPL patients who subsequently miscarry should be investigated in future larger studies