Quinones and non-quinones from the defensive secretion of unciger transsilvanicus (Verhoeff, 1899) (diplopoda, julida, julidae), from Serbia

A complex mixture of compounds was identified from the secretion of specimens of Unciger transsilvanicus. Phenol and p-cresol were detected for the first time in the family Julidae, and for the second time in the order Julida. Thirteen quinones were identified, with a great relative abundance of toloquinone and 2-methoxy-3-methyl- 1,4-benzoquinone. Hydroquinone was detected for the first time in the order Julida. Besides these compounds, isopentyl hexacosatetraenoate and isopentyl esters of saturated and unsaturated fatty acids with chain lengths from C-14 to C(20)were identified. The most abundant non-quinone compound was isopentyl eicosenoate. The relative abundance of quinone and non-quinone in the defensive fluid of U transsilvanicus was 77% and 23%, respectively. The phylogenetic importance of the registered compounds is briefly discussed

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Development of eStudent iOS mobile application

Abstract— iOS is the Apple mobile operating system, for Apple mobile devices. Initially developed for iPhone, and later for iPod Touch, iPad, AppleTV. The Metropolitan University has a Web application titled eStudent, which enables students by Web to get information about their marks for all subjects, their financies, exam scheduling, professors and assistents, and send exam registration and feedback about teaching, etc. This paper explains the development of the mobile application eStudent on the iOS platform. This application enables students whenever they want, by using their iPhone mobile phone, to get access to the information from the eStudent Web application, and to present it on their iPhone User Interface (UI). This paper explains in details software requirements analysis, system architecture, system modelling, and UI of the eStudent iOS mobile application

OSTEOMYELITIS PATELLAE. PRESENTATION OF A PATIENT

The paper presents a case of the patient suffering from osteomvelitis patellae that emerged after the fracture of the femur. This infection was cured in the conservative way primarily with three antibiotics with respect to the antibiogram findings. The radiological and scintigraphic findings show that the process turned into the chronic one so that the endoprosthetic implantation was put off. The osteomyelitis patellae is rarely described in the literature; that is why it is presented her

Dynamic Discrete Inventory Control Model with Deterministic and Stochastic Demand in Pharmaceutical Distribution

This paper presents an inventory control problem in a private pharmaceutical distribution company from the Republic of Serbia. The company realizes that distribution within nine neighbouring countries and inventory control in the pharmaceutical supply chain is centralized. In order to constitute a conceptual model of the problem, we propose the modern control theory concept. The conceptual model is based on the specific practical assumptions and constraints of the supply chain. Thereafter, a dynamic discrete mathematical model of inventory control is formulated to reflect elements of the system and their relations. The model considers multiple pharmaceutical products, variable lead time, realized stochastics and deterministic demand, and different ordering policies (Lot for Lot and Fixed Order Quantity). Deterministic demand is represented as a sales forecast for each product per month, while stochastic demand is generated as a random variation of sales forecast in a range of ±20%. Two objective functions are defined as the maximization of the difference between planned average inventory level and realized average inventory level, and the minimization of stock-out situations. We develop a procedure for the determination of reorder points and the number of deliveries to achieve proposed objective functions. The model overcomes shortages of theoretically-based distribution requirements planning models and offers solutions to the limitations in inventory control practice. Real-life data, collected over two years, are used for the validation of the proposed model and the solution procedure. Numerical examples illustrate the model application and behaviour

MORPHOMETRIC CHARACTERISTICS OF THE PINEAL ACERVULI DURING THE HUMAN AGING

Acervuli of 30 human pineal gland, were investigated during our research. They were collected during the autopsies at the Institut for forensic medicine of the Faculty of Medicine in Niš. Pineal tissue was processed with standard histologic procedure. Then, it was cut into 10 mm thick sections which were stained with HE, PAS, AB PAS and Mallory’s trichrome connective tissue stain. After that they were analyzed with light microscope. Morphometric analysis was performed by astereologic method. The B100 double square lattice test system was used. Average area, average perimeter, average diameter and contour index were calculated for the pineal acervuli of each age group. Obtained morphometric parameters were statisticaly analyzed. Acervuli were colored blue on HE stained sections. They were PAS and AB PAS positive structures which had red colored center and blue colored periphery on Mallory’s trichrome stained sections. Laminate structure was present, but it was not so concentric as it was in pineal capsula acervuli. Acervuli of the first age group had regular shape. They were localized at the pineal gland periphery. Acervuli of the second and the third age group obtained larger dimensions and more irregular shape, which finally led to mulberry structures formation in the core of the pineal gland. They were probably the result of the conglomeration of just formed with already formed ones. The increase of the average area, average parimeter, average diameter and contour index confirmed the increase of pineal acervuli dimensions and their shape irregularity during the aging process.Therefore, pineal acervuli show the increase of dimensions and shape irregularity. Finally, the process of conglomeration leads to mulberry like structures formation, in the second and the third age group which dominate pineal tissue in these age groups

Molecular Diversity of Compounds from Pygidial Gland Secretions of Cave-Dwelling Ground Beetles: The First Evidence

Three adult cave-dwelling ground beetle species were induced to discharge secretions of their pygidial glands into vials. Dichloromethane extraction was used to obtain the secretions. In total, 42 compounds were identified by GC/MS analysis. Pheggomisetes ninae contained 32 glandular compounds, Laemostenus (Pristonychus) punctatus 13, whereas Duvalius (Paraduvalius) milutini had nine compounds. Caproic, oleic, palmitic, and stearic acids were present in the samples of all analyzed species. Undecane was predominant in the extract of L. punctatus. Palmitic acid was the major component in the secretion of D. milutini. Finally, the most abundant compounds in P. ninae secretion were heptacosene and nonacosadienes. Herein, we present the first data on the identification of pygidial gland secretion components in both troglophilous and troglobite cave-dwelling ground beetles. Some compounds are reported for the first time in the secretions of ground beetles and other higher or lower taxa. The adaptation to underground life has not led to a reduction or changes in the chemical defense mechanism in the analyzed troglophilous and troglobitic Platyninae and Trechinae taxa.Serbian Ministry of Education, Science, and Technological Development {[}173038, 172053, 173027