Flipping Argument

This project utilizes the concept of “flipping the classroom” pioneered by the Kahn Academy to help students understand Aristotelian elements of argument (ethos, pathos, and logos). The four lesson plans require students to preview existing internet resources depicting practical applications of rhetorical concepts, and then invites them to utilize these concepts in the classroom. Students learn to recognize logical fallacies and types of argumentative appeals as they are used (and misused) in popular culture and in literature. The project as a whole has the additional benefit of encouraging students to identify and critically evaluate explicit and implicit arguments in a range of media, from blogs, to YouTube videos, to television drama, to advertising. Students will gain a sense of what makes an effective argument, and how argument is deployed in daily life, popular culture and literature

Using Linguistic Features to Improve Prosody for Text-to-Speech

This thesis focuses on the problem of using text-to-speech (TTS) to synthesize speech with natural-sounding prosody. I propose a two-step process for approaching this problem. In the first step, I train text-based models to predict the locations of phrase boundaries and pitch accents in an utterance. Because these models use only text features, they can be used to predict the locations of prosodic events in novel utterances. In the second step, I incorporate these prosodic events into a text-to-speech pipeline in order to produce prosodically appropriate speech. I trained models for predicting phrase boundaries and pitch accents on utterances from a corpus of radio news data. I found that the strongest models used a large variety of features, including syntactic features, lexical features, word embeddings, and co-reference features. In particular, using a large variety of syntactic features improved performance on both tasks. These models also performed well when tested on a different corpus of news data. I then trained similar models on two conversational corpora: one a corpus of task-oriented dialogs and one a corpus of open-ended conversations. I again found that I could train strong models by using a wide variety of linguistic features, although performance dropped slightly in cross-corpus applications, and performance was very poor in cross-genre applications. For conversational speech, syntactic features continued to be helpful for both tasks. Additionally, word embedding features were particularly helpful in the conversational domain. Interestingly, while it is generally believed that given information (i.e., terms that have recently been referenced) is often de-accented, for all three corpora, I found that including co-reference features only slightly improved the pitch accent detection model. I then trained a TTS system on the same radio news corpus using Merlin, an open source DNN-based toolkit for TTS. As Merlin includes a linguistic feature extraction step before training, I added two additional features: one for phrase boundaries (distinguishing between sentence boundaries and mid-sentence phrase boundaries) and one for pitch accents. The locations of all breaks and accents for all test and training data were determined using the text-based prosody prediction models. I found that the pipeline using these new features produced speech that slightly outperformed the baseline on objective metrics such as mel-cepstral distortion (MCD) and was greatly preferred by listeners in a subjective listening test. Finally, I trained an end-to-end TTS system on data that included phrase boundaries. The model was trained on a corpus of read speech, with the locations of phrase boundaries predicted based on acoustic features, and tested on radio news stories, with phrase boundaries predicted using the text-based model. I found that including phrase boundaries lowered MCD between the synthesized speech and the original radio broadcast, as compared to the baseline, but the results of a listening test were inconclusive

Infrared and visual lunar occultations measurements of stellar diameters and new binary stars detections at the Calar Alto 1.5m telescope

We present a program of routine lunar occultations, at optical and near-IR wavelengths, recently started at the 1.5m Spanish telescope at the Calar Alto Observatory. Both a CCD and an infrared array detector are used. The program is aimed mainly at the detection and investigation of binary systems, although results in other areas of stellar research are also anticipated. Occultations are reported for a total of 40 stars. Among these, SAO 164567, SAO 78258 and AG+24 788 have been discovered to be binaries, with projected separations as small as 0.006". Furthermore, binarity is suspected in the case of SAO 78119 and SAO 79251. Additionally, the angular diameter of the late-type giant 30 Psc and of the infrared star V349 Gem have been accurately measured, this latter for the first time. We finally evaluate the instrumentation performance in terms of limiting magnitude and angular resolution, and discuss applications to larger telescopes.Comment: 15 pages, 3 figures, LaTeX, uses aa.cls. Accepted for publication in A&

Detecting Inappropriate Clarification Requests in Spoken Dialogue Systems

Spoken Dialogue Systems ask for clarification when they think they have misunderstood users. Such requests may differ depending on the information the system believes it needs to clarify. However, when the error type or location is misidentified, clarification requests appear confusing or inappropriate. We describe a classifier that identifies inappropriate requests, trained on features extracted from user responses in laboratory studies. This classifier achieves 88.5% accuracy and .885 F-measure in detecting such requests

Analysis of core samples from the BPXA-DOE-USGS Mount Elbert gas hydrate stratigraphic test well : insights into core disturbance and handling

Author Posting. © The Author(s), 2009. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in Marine and Petroleum Geology 28 (2011): 381-393, doi:10.1016/j.marpetgeo.2009.10.009.Collecting and preserving undamaged core samples containing gas hydrates from depth is difficult because of the pressure and temperature changes encountered upon retrieval. Hydrate-bearing core samples were collected at the BPXA-DOE-USGS Mount Elbert Gas Hydrate Stratigraphic Test Well in February 2007. Coring was performed while using a custom oil-based drilling mud, and the cores were retrieved by a wireline. The samples were characterized and subsampled at the surface under ambient winter arctic conditions. Samples thought to be hydrate bearing were preserved either by immersion in liquid nitrogen (LN), or by storage under methane pressure at ambient arctic conditions, and later depressurized and immersed in LN. Eleven core samples from hydrate-bearing zones were scanned using x-ray computed tomography to examine core structure and homogeneity. Features observed include radial fractures, spalling-type fractures, and reduced density near the periphery. These features were induced during sample collection, handling, and preservation. Isotopic analysis of the methane from hydrate in an initially LN-preserved core and a pressure-preserved core indicate that secondary hydrate formation occurred throughout the pressurized core, whereas none occurred in the LN-preserved core, however no hydrate was found near the periphery of the LN-preserved core. To replicate some aspects of the preservation methods, natural and laboratory-made saturated porous media samples were frozen in a variety of ways, with radial fractures observed in some LN-frozen sands, and needle-like ice crystals forming in slowly frozen clay-rich sediments. Suggestions for hydrate-bearing core preservation are presented.A portion of this work was supported by the Assistant Secretary for Fossil Energy, Office of Natural Gas and Petroleum Technology, through the National Energy Technology Laboratory, under the U.S. DOE Contract No. DE- AC02-05CH11231

Geologic controls on gas hydrate occurrence in the Mount Elbert prospect, Alaska North Slope

This paper is not subject to U.S. copyright. The definitive version was published in Marine and Petroleum Geology 28 (2011): 589-607, doi:10.1016/j.marpetgeo.2009.12.004.Data acquired at the BPXA-DOE-USGS Mount Elbert Gas Hydrate Stratigraphic Test Well, drilled in the Milne Point area of the Alaska North Slope in February, 2007, indicates two zones of high gas hydrate saturation within the Eocene Sagavanirktok Formation. Gas hydrate is observed in two separate sand reservoirs (the D and C units), in the stratigraphically highest portions of those sands, and is not detected in non-sand lithologies. In the younger D unit, gas hydrate appears to fill much of the available reservoir space at the top of the unit. The degree of vertical fill with the D unit is closely related to the unit reservoir quality. A thick, low-permeability clay-dominated unit serves as an upper seal, whereas a subtle transition to more clay-rich, and interbedded sand, silt, and clay units is associated with the base of gas hydrate occurrence. In the underlying C unit, the reservoir is similarly capped by a clay-dominated section, with gas hydrate filling the relatively lower-quality sands at the top of the unit leaving an underlying thick section of high-reservoir quality sands devoid of gas hydrate. Evaluation of well log, core, and seismic data indicate that the gas hydrate occurs within complex combination stratigraphic/structural traps. Structural trapping is provided by a four-way fold closure augmented by a large western bounding fault. Lithologic variation is also a likely strong control on lateral extent of the reservoirs, particularly in the D unit accumulation, where gas hydrate appears to extend beyond the limits of the structural closure. Porous and permeable zones within the C unit sand are only partially charged due most likely to limited structural trapping in the reservoir lithofacies during the period of primary charging. The occurrence of the gas hydrate within the sands in the upper portions of both the C and D units and along the crest of the fold is consistent with an interpretation that these deposits are converted free gas accumulations formed prior to the imposition of gas hydrate stability conditions

ACR Appropriateness Criteria® Spinal Bone Metastases

The spine is a common site of involvement in patients with bone metastases. Apart from pain, hypercalcemia, and pathologic fracture, progressive tumor can result in neurologic deterioration caused by spinal cord compression or cauda equina involvement. The treatment of spinal bone metastases depends on histology, site of disease, extent of epidural disease, extent of metastases elsewhere, and neurologic status. Treatment recommendations must weigh the risk-benefit profile of external beam radiation therapy (EBRT) for the particular individual's circumstance, including neurologic status, performance status, extent of spinal disease, stability of the spine, extra-spinal disease status, and life expectancy. Patients with spinal instability should be evaluated for surgical intervention. Research studies are needed that evaluate the combination or sequencing of localized therapies with systemic therapies including chemotherapy, hormonal therapy (HT), osteoclast inhibitors (OI), and radiopharmaceuticals. The roles of stereotactic body radiation therapy (SBRT) in the management of spinal oligometastasis, radioresistant spinal metastasis, and previously irradiated but progressive spinal metastasis are emerging, but more research is needed to validate the findings from retrospective studies. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed every 2 years by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current medical literature from peer-reviewed journals and the application of a well-established consensus methodology (modified Delphi) to rate the appropriateness of imaging and treatment procedures by the panel. In those instances where evidence is lacking or not definitive, expert opinion may be used to recommend imaging or treatment.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140115/1/jpm.2012.0376.pd

Expressions 1984

https://openspace.dmacc.edu/expressions/1008/thumbnail.jp

Intrapulmonary Pharmacokinetics of First-line Anti-tuberculosis Drugs in Malawian Patients With Tuberculosis

BACKGROUND: Further work is required to understand the intrapulmonary pharmacokinetics of first-line anti-tuberculosis drugs. This study aimed to describe the plasma and intrapulmonary pharmacokinetics of rifampicin, isoniazid, pyrazinamide, and ethambutol, and explore relationships with clinical treatment outcomes in patients with pulmonary tuberculosis. METHODS: Malawian adults with a first presentation of microbiologically-confirmed pulmonary tuberculosis received standard 6-month first-line therapy. Plasma and intrapulmonary samples were collected 8 and 16 weeks into treatment and drug concentrations measured in plasma, lung/airway epithelial lining fluid, and alveolar cells. Population pharmacokinetic modelling generated estimates of drug exposure (Cmax and AUC) from individual-level post-hoc Bayesian estimates of plasma and intrapulmonary pharmacokinetics. RESULTS: One-hundred-and-fifty-seven patients (58% HIV co-infected) participated. Despite standard weight-based dosing, peak plasma concentrations of first-line drugs were below therapeutic drug monitoring targets. Rifampicin concentrations were low in all three compartments. Isoniazid, pyrazinamide, and ethambutol achieved higher concentrations in epithelial lining fluid and alveolar cells than plasma. Isoniazid and pyrazinamide concentrations were 14.6 (95% CI: 11.2-18.0) and 49.8-fold (95% CI: 34.2-65.3) higher in lining fluid than plasma respectively. Ethambutol concentrations were highest in alveolar cells (alveolar cells:plasma ratio 15.0, 95% CI 11.4-18.6). Plasma or intrapulmonary pharmacokinetics did not predict clinical treatment response. CONCLUSIONS: We report differential drug concentrations between plasma and the lung. While plasma concentrations were below therapeutic monitoring targets, accumulation of drugs at the site of disease may explain the success of the first-line regimen. The low rifampicin concentrations observed in all compartments lend strong support for ongoing clinical trials of high-dose rifampicin regimens