Buying for a Cause: Consumer Attitudes Towards Cause Marketing, Using Theory of Planned Behavior

This research was conducted to learn if consumer attitudes and purchase intentions of cause marketing products could be recognized and better understood by applying Icek Ajzen’s Theory of Planned Behavior (TPB). Specifically, the researcher intended to learn more about consumer participation in cause marketing programs and to start a discussion about what consumers expect or hope to gain from their participation. This study applied purchase-triggered donation cause marketing to a post-test experimental design to investigate if purchase intentions are higher when a cause marketing appeal was present and to learn more about the application of TPB in cause marketing consumer behavior. Two random samples of 1000 students were invited to participate in this questionnaire-based, online study which yielded an average 24.6% response rate from the control group and experimental groups. Analyses of the data showed a favorable application of TPB using a path model and multiple regression and a positive application of anticipated affect, an extension of TPB that factors in expectations of emotions after performing a behavior. Multiple regression revealed that cognitive items influenced by the stimulus scenario were diminished when affect is considered and feelings of happiness, satisfaction, guiltlessness, and responsibility were brought to the forefront. The researcher concluded that cause marketing is an effective marketing tool that plays on the emotions of consumer altruism, and TPB with the extension of anticipated affect is an effective model to study the consumer beliefs and attitudes that contribute to the purchase of cause marketing products

Not \u27Just My Problem to Handle\u27: Emerging Themes on Secondary Trauma and Archivists

This article reports on the findings of a survey issued to Canadian archivists regarding their understanding and experiences of secondary trauma. As exploratory research, the article summarizes findings of the survey and identifies emerging themes based on qualitative analysis of the open-ended questions. Emerging themes relate to the difficulty of defining what constitutes a traumatic record; working with donors and researchers; the effects of organizational culture and archival professional norms; the impact of precarious labor on experiences of trauma; and the role of archival education programs and professional associations in preparing and supporting archivists to work with difficult materials. The article concludes by outlining an agenda for future research

One Hundred Voices: Harrisburg’s Historic African American Community, 1850-1920

In 2020, a coalition of citizens, organizers, legislators, and educators came together to commemorate the Fifteenth and Nineteenth Amendments by establishing a new monument in Harrisburg, Pennsylvania. This would be a memorial dedicated to the capital city’s significant African American community and its historic struggle for the vote. The Commonwealth Monument, located on the Irvis Equality Circle on the South Lawn of Pennsylvania’s State Capitol Grounds, features a bronze pedestal inscribed with one hundred names of change agents who pursued the power of suffrage and citizenship between 1850 and 1920. This book is a companion to this monument and tells the stories of those one hundred freedom seekers, abolitionists, activists, suffragists, moralists, policemen, masons, doctors, lawyers, musicians, poets, publishers, teachers, preachers, housekeepers, janitors, and business leaders, among many others. In their committed advocacy for freedom, equality, and justice, these inspiring men and women made unique and lasting contributions to the standing and life of African Americans—and, indeed, the political power of all Americans—within their local communities and across the country. Calobe Jackson, Jr., is an historian of Harrisburg African American studies, Katie Wingert McArdle is a writer and researcher currently serving as the head swim coach at Dickinson College, and David Pettegrew is a professor of history at Messiah University. ~ This book emerged at the intersection of the Commonwealth Monument Project (for more on that go here) and the Digital Harrisburg project (for more on that go here). This work is continuing. For example, check out the work of the Digital Harrisburg team discussing the region’s difficult history of racial injustice here.https://commons.und.edu/press-books/1016/thumbnail.jp

Exploratory analysis of estrogen-mediated gene expression in central ghrelin signaling pathways

Introduction & Objective: As of 2020, 67% of Americans are overweight or obese. Particularly concerning is the greater incidence of obesity in post-menopausal women. Previous studies have shown that estrogen decreases food intake and body weight; however, it is not yet clear the method by which estrogen affects central pathways that regulate feeding. To address this, we used a microarray to compare estrogen-mediated changes in gene expression within the leptin signaling pathway. This pathway contains brain areas known to be involved in food intake including: the arcuate nucleus of the hypothalamus (ARC), the paraventricular nucleus of the hypothalamus (PVN), and nucleus of the solitary tract (NTS).Methods: Adult female rats were bilaterally ovariectomized and treated with either oil or estrogen injections. After termination, RNA was collected from the ARC, PVN, and NTS. Isolated RNA was sent to Thermo Fisher Scientific for microarray analysis. Results were analyzed using Transcriptome Analysis Console software.Results: In the brain areas investigated, we found that estrogen influenced gene expression for multiple neurotransmitters, neuroreceptors, and signaling molecules involved in the leptin signaling pathway.Conclusion: The changes in body and uterine weights confirmed the effects of estrogen. The ARC, PVN, and NTS displayed a variety of genes regulated by estrogen, confirming that estrogen mediates gene expression within the leptin signaling pathway. This demonstrates a potential mechanism by which estrogen affects central pathways to decrease food intake and body weight

Quantitative Analysis of Outer Retinal Tubulation in Age-Related Macular Degeneration From Spectral-Domain Optical Coherence Tomography and Histology

Purpose: To assess outer retinal tubulation (ORT) morphology from spectral-domain optical coherence tomography (SD-OCT) volumes and donor eye histology, analyze ORT reflectivity, and estimate the number of cones surviving in ORT. Methods: In SD-OCT volumes from nine patients with advanced AMD, ORT was analyzed en face and in B-scans. The hyperreflective ORT border in cross-section was delineated and surface area calculated. Reflectivity was compared between ORT types (Closed, Open, Forming, and Branching). A flatmount retina from a donor with neovascular AMD was labeled to visualize the external limiting membrane that delimits ORT and allow measurements of cross-sectional cone area, center-to-center cone spacing, and cone density. The number of cones surviving in ORT was estimated. Results: By en face SD-OCT, ORT varies in complexity and shape. Outer retinal tubulation networks almost always contain Closed cross-sections. Spectral-domain OCT volumes containing almost exclusively Closed ORTs showed no significant direction-dependent differences in hyperreflective ORT border intensity. The surface areas of partial ORT assessed by SD-OCT volumes ranged from 0.16 to 1.76 mm2. From the flatmount retina, the average cross-sectional area of cone inner segments was 49.1 ± 7.9 μm2. The average cone spacing was 7.5 ± 0.6 μm. Outer retinal tubulation cone density was 20,351 cones/mm2. The estimated number of cones in ORT in a macula ranged from 26,399 to 186,833 cones, which is 6% to 44% of the cones present in a healthy macula. Conclusions: These first estimates for cone density and number of cones surviving in ORT suggest that ORT formation considerably distorts the photoreceptor mosaic. Results provide additional insight into the reflectivity characteristics and number of ORT cones observable in living patients by SD-OCT, as cones persist and disease progresses

Health professionals' experiences of tuberculosis cohort audit in the North West of England : a qualitative study

This research was supported by Public Health England and the Centre for Applied Health Research and Delivery, Liverpool School of Tropical Medicine (LSTM).Objectives. Tuberculosis cohort audit (TBCA) was introduced across the North West (NW) of England in 2012 as an ongoing, multidisciplinary, systematic case review process, designed to improve clinical and public health practice. TBCA has not previously been introduced across such a large and socioeconomically diverse area in England, nor has it undergone formal, qualitative evaluation. This study explored health professionals' experiences of the process after 1515 cases had been reviewed. Design. Qualitative study using semistructured interviews. Respondents were purposively sampled from 3 groups involved in the NW TBCA: (1) TB nurse specialists, (2) consultant physicians and (3) public health practitioners. Data from the 26 respondents were triangulated with further interviews with key informants from the TBCA Steering Group and through observation of TBCA meetings. Analysis. Interview transcripts were analysed thematically using the framework approach. Results. Participants described the evolution of a valuable 'community of practice' where interprofessional exchange of experience and ideas has led to enhanced mutual respect between different roles and a shared sense of purpose. This multidisciplinary, regional approach to TB cohort audit has promoted local and regional team working, exchange of good practices and local initiatives to improve care. There is strong ownership of the process from public health professionals, nurses and clinicians; all groups want it to continue. TBCA is regarded as a tool for quality improvement that improves patient safety. Conclusions. TBCA provides peer support and learning for management of a relatively rare, but important infectious disease through discussion in a no-blame atmosphere. It is seen as an effective quality improvement strategy which enhances TB care, control and patient safety. Continuing success will require increased engagement of consultant physicians and public health practitioners, a secure and ongoing funding stream and establishment of clear reporting mechanisms within the public health system.Publisher PDFPeer reviewe

The translocator protein (TSPO) genetic polymorphism A147T is associated with worse survival in male glioblastoma patients

Glioblastoma (GBM) is the most common primary brain tumor in adults, with few available therapies and a five-year survival rate of 7.2%. Hence, strategies for improving GBM prognosis are urgently needed. The translocator protein 18kDa (TSPO) plays crucial roles in essential mito-chondria-based physiological processes and is a validated biomarker of neuroinflammation, which is implicated in GBM progression. The TSPO gene has a germline single nucleotide polymorphism, rs6971, which is the most common SNP in the Caucasian population. High TSPO gene expression is associated with reduced survival in GBM patients; however, the relation between the most fre-quent TSPO genetic variant and GBM pathogenesis is not known. The present study retrospectively analyzed the correlation of the TSPO polymorphic variant rs6971 with overall and progression-free survival in GBM patients using three independent cohorts. TSPO rs6971 polymorphism was signif-icantly associated with shorter overall survival and progression-free survival in male GBM patients but not in females in one large cohort of 441 patients. We observed similar trends in two other independent cohorts. These observations suggest that the TSPO rs6971 polymorphism could be a significant predictor of poor prognosis in GBM, with a potential for use as a prognosis biomarker in GBM patients. These results reveal for the first time a biological sex-specific relation between rs6971 TSPO polymorphism and GBM

Optical Tastebuds for Water Quality Testing

To achieve the UN Sustainable Development Goal of universal access to clean water and sanitation, we need to rethink centralized water systems with global net-zero carbon and sustainability in mind. One approach is to develop scalable off-grid systems that are reliable and easy to use and maintain. A major challenge for such systems is translating the standard laboratory-based monitoring of centralized systems to a more sustainable and scalable model for regularly and routinely monitoring system outputs, which consist of complex mixtures with varying concentrations of molecules and ions in water. Here, we demonstrate a preliminary sensor that, once fully developed, could allow for point-of-use measurements with a single output to monitor. Rather than developing multiple sensors to monitor the levels of each individual component in the water, our label-free, array-based design mimics the biological system of taste. The sensor is comprised of an array of nano-tastebuds made of tailored plasmonic metasurfaces. The combination of different signals from each nano-tastebud to the same sample yields a unique fingerprint for that sample. Through training, these fingerprints build an identification model. By integrating a fully developed sensor into decentralized water systems, we seek to provide non-expert end-users with an easy-to-read output capable of warning of imminent system failures

Optical Tastebuds for Water Analysis

We demonstrate a preliminary nano-tastebud sensor comprised of tailored plasmonic metasurfaces that, once fully developed, could be integrated into water treatment facilities as an early warning system to warn of imminent system failures

Development and evaluation of a low‐cost lego 3d bioprinter: from building‐blocks to building blocks of life

The development of low‐cost accessible technologies for rapid prototyping of mechanical components has democratised engineering tools for hobbyists and researchers alike. The development of analogous approaches to fabrication of soft‐matter, and biologically compatible materials containing living cells, is anticipated to be similarly enabling across multiple fields of biological research. LEGO toy construction bricks represent low‐cost, precision engineered, and versatile construction materials for rapid prototyping. This study demonstrates construction of a benchtop LEGO 3D bioprinter for additive layer manufacture of a 3D structure containing viable human skin cells within a hydrogel scaffold. 3D bioprinted structures are formed from the deposition of microfluidically generated bio‐ink droplets containing live keratinocyte skin cells, representing components toward an artificial skin model. Fluid flow rates and printer speed, together with bio‐ink gelation rate, determine droplet packing arrangement in the bioprinted structures. The printing of 3D structures containing multiple bio‐inks is demonstrated and live cells are imaged in the resulting bioprints. Fluid delivery can be achieved using LEGO pumps and readily available, or home‐3D‐printed, microfluidic components, therefore avoiding the need for any specialist microfluidic hardware. Build instructions are described to enable easy uptake, modification and improvement by other laboratories, as well provide an accessible platform for learning and education. Affordable, accessible, and easy to use tools for 3D bioprinting are anticipated to open opportunities for a greater number of research labs to work with 3D cell culture and bio‐printed materials, with bioprinting expected to assist in better understanding of disease, contribute to tissue engineering and repair, and enable personalised medicine through the printing of cultured patient cells. The presented approach is not only an easily accessible laboratory tool for bioprinting, but also provides a learning system for mechanical construction, robotics, coding, microfluidics and cell biology, making it a versatile platform for research, education, and science engagement