513 research outputs found
Amplitude Modulation and Relaxation-Oscillation of Counterpropagating Rolls within a Broken-Symmetry Laser-Induced Electroconvection Strip
We report a liquid-crystal pattern-formation experiment in which we break the
lateral (translational) symmetry of a nematic medium with a laser-induced
thermal gradient. The work is motivated by an improved measurement (reported
here) of the temperature dependence of the electroconvection threshold voltage
in planar-nematic 4-methoxybenzylidene-4-butylaniline (MBBA). In contrast with
other broken-symmetry-pattern studies that report a uniform drift, we observe a
strip of counterpropagating rolls that collide at a sink point, and a strong
temporally periodic amplitude modulation within a width of 3-4 rolls about the
sink point. The time dependence of the amplitude at a fixed position is
periodic but displays a nonsinusoidal relaxation-oscillation profile. After
reporting experimental results based on spacetime contours and wavenumber
profiles, along with a measurement of the change in the drift frequency with
applied voltage at a fixed control parameter, we propose some potential
guidelines for a theoretical model based on saddle-point solutions for
Eckhaus-unstable states and coupled complex Ginzburg-Landau equations.
Published in PRE 73, 036317 (2006).Comment: Published in Physical Review E in March 200
Failure to Preserve β-Cell Function With Mycophenolate Mofetil and Daclizumab Combined Therapy in Patients With New- Onset Type 1 Diabetes
OBJECTIVE This trial tested whether mycophenolate mofetil (MMF) alone or with daclizumab (DZB) could arrest the loss of insulin-producing β-cells in subjects with new-onset type 1 diabetes.
RESEARCH DESIGN AND METHODS A multi-center, randomized, placebo-controlled, double-masked trial was initiated by Type 1 Diabetes TrialNet at 13 sites in North America and Europe. Subjects diagnosed with type 1 diabetes and with sufficient C-peptide within 3 months of diagnosis were randomized to either MMF alone, MMF plus DZB, or placebo, and then followed for 2 years. The primary outcome was the geometric mean area under the curve (AUC) C-peptide from the 2-h mixed meal tolerance test.
RESULTS One hundred and twenty-six subjects were randomized and treated during the trial. The geometric mean C-peptide AUC at 2 years was unaffected by MMF alone or MMF plus DZB versus placebo. Adverse events were more frequent in the active therapy groups relative to the control group, but not significantly.
CONCLUSIONS Neither MMF alone nor MMF in combination with DZB had an effect on the loss of C-peptide in subjects with new-onset type 1 diabetes. Higher doses or more targeted immunotherapies may be needed to affect the autoimmune process
Trends of Earlier and Later Responses of C-peptide to Oral Glucose Challenges With Progression to Type 1 Diabetes in Diabetes Prevention Trial–Type 1 Participants
Incident Dysglycemia and Progression to Type 1 Diabetes Among Participants in the Diabetes Prevention Trial–Type 1
Glucose Excursions Between States of Glycemia With Progression to Type 1 Diabetes in the Diabetes Prevention Trial–Type 1 (DPT-1)
Statistical Inference for Valued-Edge Networks: Generalized Exponential Random Graph Models
Across the sciences, the statistical analysis of networks is central to the
production of knowledge on relational phenomena. Because of their ability to
model the structural generation of networks, exponential random graph models
are a ubiquitous means of analysis. However, they are limited by an inability
to model networks with valued edges. We solve this problem by introducing a
class of generalized exponential random graph models capable of modeling
networks whose edges are valued, thus greatly expanding the scope of networks
applied researchers can subject to statistical analysis
Glucose and C-Peptide Changes in the Perionset Period of Type 1 Diabetes in the Diabetes Prevention Trial–Type 1
OBJECTIVE—We examined metabolic changes in the period immediately after the diagnosis of type 1 diabetes and in the period leading up to its diagnosis in Diabetes Prevention Trial–Type 1 (DPT-1) participants
Intensive Glycemic Control and the Prevention of Cardiovascular Events: Implications of the ACCORD, ADVANCE, and VA Diabetes Trials: A position statement of the American Diabetes Association and a scientific statement of the American College of Cardiology Foundation and the American Heart Association
A mathematical model for mechanical activation and compound action potential generation by the utricle in response to sound and vibration
IntroductionCalyx bearing vestibular afferent neurons innervating type I hair cells in the striolar region of the utricle are exquisitely sensitive to auditory-frequency air conducted sound (ACS) and bone conducted vibration (BCV). Here, we present experimental data and a mathematical model of utricular mechanics and vestibular compound action potential generation (vCAP) in response to clinically relevant levels of ACS and BCV. Vibration of the otoconial layer relative to the sensory epithelium was simulated using a Newtonian two-degree-of-freedom spring-mass-damper system, action potential timing was simulated using an empirical model, and vCAPs were simulated by convolving responses of the population of sensitive neurons with an empirical extracellular voltage kernel. The model was validated by comparison to macular vibration and vCAPs recorded in the guinea pig, in vivo.ResultsTransient stimuli evoked short-latency vCAPs that scaled in magnitude and timing with hair bundle mechanical shear rate for both ACS and BCV. For pulse BCV stimuli with durations <0.8 ms, the vCAP magnitude increased in proportion to temporal bone acceleration, but for pulse durations >0.9 ms the magnitude increased in proportion to temporal bone jerk. Once validated using ACS and BCV data, the model was applied to predict blast-induced hair bundle shear, with results predicting acute mechanical damage to bundles immediately upon exposure.DiscussionResults demonstrate the switch from linear acceleration to linear jerk as the adequate stimulus arises entirely from mechanical factors controlling the dynamics of sensory hair bundle deflection. The model describes the switch in terms of the mechanical natural frequencies of vibration, which vary between species based on morphology and mechanical factors
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