Effect of selenium treated broccoli on herbivory and oviposition preferencesof Delia radicum and Phyllotreta spp.

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Primary debulking surgery versus primary neoadjuvant chemotherapy for high grade advanced stage ovarian cancer: Comparison of survivals

The aim of the study was to analyze the overall survival (OS) and progression free survival (PFS) of patients with high grade and advanced stage epithelial ovarian cancer (EOC) with at least 60 months of follow-up treated in a single gynecologic oncology institute. We compared primary debulking surgery (PDS) versus neoadjuvant chemotherapy plus interval debulking surgery (NACT + IDS) stratifying data based on residual disease with the intent to identify the rationale for therapeutic option decision and the role of laparoscopic evaluation of resectability for that intention. This is observational retrospective study on consecutive patients with diagnosis of high grade and International Federation of Gynecology and Obstetrics (FIGO) stage III/IV EOC referred to our center between January 2008 and May 2012. We selected only patients with a follow-up of at least 60 months. Primary endpoint was to compare PDS versus NACT + IDS in term of progression free survival (PFS) and overall survival (OS). Secondary endpoints were PFS and OS stratifying data according to residual disease after surgery in patients receiving PDS versus NACT + IDS. Finally, through Cox hazards models, we tested the prognostic value of different variables (patient age at diagnosis, residual disease after debulking, American Society of Anesthesiologists (ASA) stage, number of adjuvant-chemotherapy cycles) for predicting OS. A total number of 157 patients were included in data analysis. Comparing PDS arm (108 patients) and NACT + IDS arm (49 patients) we found no significant differences in term of OS (41.3 versus 34.5 months, respectively) and PFS (17.3 versus 18.3 months, respectively). According to residual disease we found no significant differences in term of OS between NACT + IDS patients with residual disease = 0 and PDS patients with residual disease = 0 or residual disease = 1, as well as no significant differences in PFS were found comparing NACT + IDS patients with residual disease = 0 and PDS patients with residual disease = 0; contrarily, median PFS resulted significantly lower in PDS patients receiving optimal debulking (residual disease = 1) in comparison to NACT + IDS patients receiving complete debulking (residual disease = 0). PDS arm was affected by a significant higher rate of severe post-operative complications (grade 3 and 4). Diagnostic laparoscopy before surgery was significantly associated with complete debulking. We confirm previous findings concerning the non-superiority of NACT + IDS compared to PDS for the treatment of EOC, even if NACT + IDS treatment was associated with significant lower rate of post-operative complications. On the other hand, selecting patients for NACT + IDS, based on laparoscopic evaluation of resectabilty prolongs the PFS and does not worse the OS compared to the patients not completely debulked with PDS

Some functional equations related to the characterizations of information measures and their stability

The main purpose of this paper is to investigate the stability problem of some functional equations that appear in the characterization problem of information measures.Comment: 36 pages. arXiv admin note: text overlap with arXiv:1307.0657, arXiv:1307.0631, arXiv:1307.0664, arXiv:1307.065

Attaining composure through breath-awareness: a phenomenological account of the use of the breath in social work

This article is the first to address breathing in social work directly. It sits within the phenomenological tradition and as such provides accounts from social work education and practice as a means of recognizing a commonality of experience. The article argues for a considered, conscious use of the breath in order for the social worker to gain a state of calm or composure and also to be able to foster composure in others – the so called “circle of breath”. The focus is on the skills of the worker but also on the meanings of the choices they make. A phenomenological approach to the topic of composure is contrasted with a psychotherapeutic approach. No particular method is advocated although several exercises designed to aid breath awareness are suggested. A discussion is threaded throughout on the relationship between the breath and spirituality in social work, also considered in phenomenological terms