The clinical significance of the FUS-CREB3L2 translocation in low-grade fibromyxoid sarcoma

<p>Abstract</p> <p>Background</p> <p>Low-grade fibromyxoid sarcoma (LGFMS) is a rare soft-tissue neoplasm with a deceptively benign histological appearance. Local recurrences and metastases can manifest many years following excision. The <it>FUS-CREB3L2 </it>gene translocation, which occurs commonly in LGFMS, may be detected by reverse-transcriptase polymerase chain reaction (RT-PCR) and fluorescence in situ hybridisation (FISH). We assessed the relationship between clinical outcome and translocation test result by both methods.</p> <p>Methods</p> <p>We report genetic analysis of 23 LGFMS cases and clinical outcomes of 18 patients with mean age of 40.6 years. During follow-up (mean 24.8 months), there were no cases of local recurrence or metastasis. One case was referred with a third recurrence of a para-spinal tumour previously incorrectly diagnosed as a neurofibroma.</p> <p>Results</p> <p>Results showed 50% of cases tested positive for the <it>FUS-CREB3L2 </it>translocation by RT-PCR and 81.8% by FISH, suggesting FISH is more sensitive than RT-PCR for confirming LGFMS diagnosis. Patients testing positive by both methods tended to be younger and had larger tumours. Despite this, there was no difference in clinical outcome seen during short and medium-term follow-up.</p> <p>Conclusions</p> <p>RT-PCR and FISH for the <it>FUS-CREB3L2 </it>fusion transcript are useful tools for confirming LGFMS diagnosis, but have no role in predicting medium-term clinical outcome. Due to the propensity for late recurrence or metastasis, wide excision is essential, and longer-term follow-up is required. This may identify a difference in long-term clinical outcome between translocation-positive and negative patients.</p

Rose Skinner, soprano; Ross Martin, piano. Lynette Stoyles, flute; Sally Rowsell, piano; Darlene Delay, soprano

Rose Skinner, soprano; Ross Martin, piano. Lynette Stoyles, flute; Sally Rowsell, piano; Darlene Delay, sopran

Prospectus, October 19, 1977

WPCD GOES ON AIR JANUARY \u2778: KELLY; Security stymies petrol pilferers; Propeck resigns as Stu-Go secretary; Thompson vetoes House community college bill; Canteen hit again; Parkland Events; \u27Who\u27s Who… candidates due; Letters to the editor: Some thoughts on a lost friend..., Head Start Follow Up Program needs tutors, ...\u27why headlined?\u27, On student directories - \u27not hired to correct\u27; Thompson seeks candidates for national awards; ACT Test Oct. 27; Phone line available for disabled; Blood drive is \u27successful\u27; Student Directory problem brought before Stu-Go; Have any suggestions?; CCWAR begins training; Danville DJ not quite ready for funny farm; Art group meets tonight; U.S. goes hosteling; Fear of dentists extracted by psych project; CHI, Women\u27s Program sponsor workshop Oct. 27; Don\u27t buy the book: How to save money through the mail; Tours this fall for U. of I.\u27s IMPE; Classifieds; Trout not pleased with women\u27s 8-5 record; K-Action continues winning ways in IM; Halloween activities on October 27; Art students are working for spring show; A review: Moliere adaptation Scapino was \u27zany\u27; Graphic Art competitions at U. of I.; Upsets cause trouble 10-for-12 Freddy; Indoor tracksters are balanced team; Fast Freddy Football Forecast; Danville drives for CIAC title, Parkland second?; Three run best ever at DuPage; Golfers 14th of 20 at Lincoln Landhttps://spark.parkland.edu/prospectus_1977/1008/thumbnail.jp

Maternal and paternal depressive symptoms and parental vocalisation behaviours in infancy: findings from UK-based birth cohort

Background: Both maternal and paternal postnatal depression (PND) are associated with increased risk of less optimal offspring developmental outcomes. Early exposure to differences in maternal and paternal vocalisation behaviours associated with maternal and paternal PND may be important in this relationship. However, little research has captured vocalisation patterns at home without researchers present. Objectives This study sought to examine the associations between maternal and paternal PND and various aspects of parental vocalisation behaviours. Methods: Mothers (n = 104) and fathers (n = 34) of six-months old infants from the Avon Longitudinal Study of Parents and Children Generation-2 (ALSPAC-G2) provided video footage of mother- and father-infant interactions filmed at home using the head-worn video cameras (headcams) without the need for researchers to be present. Twenty-five mother-infant and father-infant interactions were coded on multiple aspects of parental and infant vocalisation behaviours using the micro-behavioural observational coding system. Parental (PND) was measured using the Edinburgh Postnatal Depression Scale (EPDS; total score). Results: Frequencies and duration of vocalisation behaviours were similar in mothers and fathers. However, there was an indication that fathers demonstrated higher frequency and duration of commands, exclamations and ironic/sarcastic tone, and criticisms compared to mothers, while mothers engaged in more teaching compared to fathers. Linear regression models indicated that maternal and paternal PND were not associated with the majority of vocalisation behaviours. However, there were some specific patterns observed, mostly related to the emotional tone of the vocalisations. Higher levels of maternal PND were associated with lower frequency of speech in a neutral tone, frequency and duration of use of humour, and increased duration of speech in a positive tone. Higher levels of paternal PND were associated with higher mean duration of speech, infant-directed speech, higher frequency and duration of laughing, and increased duration of speech using questions and encouragement. Conclusion: These findings extend existing research by investigating the associations between maternal and paternal PND and a wide range of vocalisation behaviours captured and coded using innovative methods and in a more ecologically valid way than previous studies

An Evaluation of the Diagnostic Accuracy of the Grade of Preoperative Biopsy Compared to Surgical Excision in Chondrosarcoma of the Long Bones

Chondrosarcoma is the second most common primary malignant bone tumour. Distinguishing between grades is not necessarily straightforward and may alter the disease management. We evaluated the correlation between histological grading of the preoperative image-guided needle biopsy and the resection specimen of 78 consecutive cases of chondrosarcoma of the femur, humerus, and tibia. In 11 instances, there was a discrepancy in histological grade between the biopsy and surgical specimen. Therefore, there was an 85.9% (67/78) accuracy rate for pre-operative histological grading of chondrosarcoma, based on needle biopsy. However, the accuracy of the diagnostic biopsy to distinguish low-grade from high-grade chondrosarcoma was 93.6% (73/78). We conclude that accurate image-guided biopsy is a very useful adjunct in determining histological grade of chondrosarcoma and the subsequent treatment plan. At present, a multidisciplinary approach, comprising experienced orthopaedic surgeons, radiologists, and pathologists, offers the most reliable means of accurately diagnosing and grading of chondrosarcoma of long bones

Opacity calculation for target physics using the ABAKO/RAPCAL code

Radiative properties of hot dense plasmas remain a subject of current interest since they play an important role in inertial confinement fusion (ICF) research, as well as in studies on stellar physics. In particular, the understanding of ICF plasmas requires emissivities and opacities for both hydro-simulations and diagnostics. Nevertheless, the accurate calculation of these properties is still an open question and continuous efforts are being made to develop new models and numerical codes that can facilitate the evaluation of such properties. In this work the set of atomic models ABAKO/RAPCAL is presented, as well as a series of results for carbon and aluminum to show its capability for modeling the population kinetics of plasmas in both LTE and NLTE regimes. Also, the spectroscopic diagnostics of a laser-produced aluminum plasma using ABAKO/RAPCAL is discussed. Additionally, as an interesting application of these codes, fitting analytical formulas for Rosseland and Planck mean opacities for carbon plasmas are reported. These formulas are useful as input data in hydrodynamic simulation of targets where the computation task is so hard that in line computation with sophisticated opacity codes is prohibitive