Georgia's Exemplary Public High School Librarians and Information Literacy Skills Instruction

This case study was conducted to examine the practices and procedures of public high school library media specialists in the state of Georgia in order to identify teaching and administrative methods they commonly utilize. The study focused on three high school librarians identified as exceptional through either their achievement of National Board Teaching Certification, by honors and awards granted them by the state of Georgia’s Department of Education, or by recognition of their excellence as judged by their peers in the Georgia Library Media Association and the Georgia Association of Instructional Technology. School demographics, test scores, web presence, and usage of Georgia Library Learning Online were also scrutinized. Two English teachers working with each school library media specialist were interviewed to obtain further evidence of the librarians’ work. Themes emerging from the data indicated that these exemplary school library media specialists make definite and positive contributions to each of their schools. The themes for this study were identified as Leadership, Information Literacy, Collaboration, School Culture, and Administration. The results further suggested that while there is no specific formula for an exceptional program, there are commonalities of practice for school libraries that reflect the Standards for Initial Preparation of School Librarians (American Association of School Librarians & American Library Association, 2010) and on the criteria delineated by the state of Georgia and communities of practice.I. INTRODUCTION - 1 Statement of the Problem - 2 Conceptual Framework of the Study - 4 Purpose of the Study… - 9 Research Questions - 11 Definition of Terms - 11 Significance of the Study - 13 Assumptions of the Study - 14 Limitations of the Study - 14 Organization of the Study - 15 II. REVIEW OF LITERATURE - 17 History of Guidelines for School Libraries - 18 Information Literacy - 21 Perceptions of the Role of the Librarian - 28 School Library Media Specialists in Georgia - 30 Georgia’s School Libraries and Funding - 32 Recognition for Excellence - 33 School Libraries and School Culture - 35 The Standards - 36 AASL Standard 1: Teaching for Learning - 37 AASL Standard 2: Literacy and Reading - 42 AASL Standard 3: Information and Knowledge - 43 AASL Standard 4: Advocacy and Leadership - 46 AASL Standard 5: Management and Administration - 47 Summary - 48 III. METHODOLOGY - 50 Introduction - 50 Research Questions - 51 Rationale for Qualitative Methods - 52 Participant Selection - 53 Data Collection - 55 Interviews - 55 Non-Participant Observation - 56 Documents - 58 Reflective Journal - 59 Data Analysis - 60 Limitations of the Study - 61 Validation Strategies - 62 Ethical Considerations - 63 The Role and Background of the Researcher - 63 IV. RESULTS - 68 Introduction - 68 Methodology - 68 Research Questions - 69 Data Analysis Procedures - 70 Introduction of School Sites and Participants - 71 Taylorville High School - 72 Bernton High School - 73 Easton High School - 73 Media Specialists and Teachers - 74 Case Studies - 75 Case Study 1: Curtis Lynch, Taylorville High School - 75 Cecile Thomas: Teacher, Taylorville High School - 81 Debbie Chamness: Teacher, Taylorville High School - 82 Categories for Taylorville High School - 82 Case Study 2: Tara Simmons, Bernton High School - 85 Laura Murray: Teacher, Bernton High School - 90 Sarah Carpenter: Teacher, Bernton High School - 91 Categories for Bernton High School - 91 Case Study 3: Linette Jenkins, Media Specialist, Easton High School - 95 Denise Berry: Teacher, Easton High School - 99 Ann Shipley: Teacher, Easton High School - 99 Categories for Easton High School - 100 Cross Case Analyses - 103 Themes - 108 Summary - 111 V. DISCUSSION, IMPLICATIONS, FUTURE RESEARCH - 114 Conceptual Framework and Results of the Study - 115 Discussion of Findings - 116 Research Question 1.116 Research Question 2.121 Research Question 3.131 Administration: Technology Issues - 135 Administration: Funding and Staff - 137 Future Research - 140 Limitations of the Study - 142 Implications - 143 Conclusions - 143 REFERENCES - 147 APPENDICES - 173 Appendix A: Letter of Invitation to Participate - 174 Appendix B: Interview Questions for Media Specialists - 176 Appendix C: Interview Questions for English Teachers - 179 Appendix D: Observation Protocols - 182 Appendix E: Institutional Review Board Exemption Protocol Report - 183Not Submitted, NullEd. D.Curriculum and Instructio

Expectations of successful female small school principals

This paper forms part of a larger study investigating the experiences of twelve female teaching principals in small rural and isolated schools in their first year as school principal. The schools to which they were appointed had student enrolments ranging from 12 to 86 and were in geographic areas with no township, where the school building was the only structure, to small towns of less than 500. This study sought to discover the expectations stakeholders in small schools had of successful female teaching principals and the expectations teaching principals had of themselves. Interviews with both cohorts indicated a shared expectation that the teaching principal would come equipped with excellent communication skills, sound teaching knowledge and the ability to establish and maintain community relationships. Additional expectations from teaching principals related to their leaders hip, meeting systemic administrative requirements and balancing their work and personal lives. For stakeholders additional expectations included being organised in relation to isolation and having positive personal characteristics

Induction of MHC Class I Expression by the MHC Class II Transactivator CIITA

Major histocompatibility complex (MHC) class I–deficient cell lines were used to demonstrate that the MHC class II transactivator (CIITA) can induce surface expression of MHC class I molecules. CIITA induces the promoter of MHC class I heavy chain genes. The site α DNA element is the target for CIITA-induced transactivation of class I. In addition, interferon-γ (IFNγ)–induced MHC class I expression also requires an intact site α. The G3A cell line, which is defective in CIITA induction, does not induce MHC class I antigen and promoter in response to IFNγ. Trans-dominant–negative forms of CIITA reduce class I MHC promoter function and surface antigen expression. Collectively, these data argue that CIITA has a role in class I MHC gene induction

Constraints on food choices of women in the UK with lower educational attainment

Constraints on food choices of women in the UK with lower educational attainmen

The Influence of Huntingtin Protein Size on Nuclear Localization and Cellular Toxicity

Huntington disease is an autosomal dominant neurodegenerative disorder caused by the pathological expansion of a polyglutamine tract. In this study we directly assess the influence of protein size on the formation and subcellular localization of huntingtin aggregates. We have created numerous deletion constructs expressing successively smaller fragments of huntingtin and show that these smaller proteins containing 128 glutamines form both intranuclear and perinuclear aggregates. In contrast, larger NH2-terminal fragments of huntingtin proteins with 128 glutamines form exclusively perinuclear aggregates. These aggregates can form in the absence of endogenous huntingtin. Furthermore, expression of mutant huntingtin results in increased susceptibility to apoptotic stress that is greater with decreasing protein length and increasing polyglutamine size. As both intranuclear and perinuclear aggregates are clearly associated with increased cellular toxicity, this supports an important role for toxic polyglutamine-containing fragments forming aggregates and playing a key role in the pathogenesis of Huntington disease

Detailed Clinical and Psychological Phenotype of the X-linked HNRNPH2-Related Neurodevelopmental Disorder

Objective: To expand the clinical phenotype of the X-linked HNRNPH2-related neurodevelopmental disorder in 33 individuals. Methods: Participants were diagnosed with pathogenic or likely pathogenic variants in HNRNPH2 using American College of Medical Genetics and Genomics/Association of Molecular Pathology criteria, largely identified via clinical exome sequencing. Genetic reports were reviewed. Clinical data were collected by retrospective chart review and caregiver report including standardized parent report measures. Results: We expand our clinical characterization of HNRNPH2-related disorders to include 33 individuals, aged 2-38 years, both females and males, with 11 different de novo missense variants, most within the nuclear localization signal. The major features of the phenotype include developmental delay/intellectual disability, severe language impairment, motor problems, growth, and musculoskeletal disturbances. Minor features include dysmorphic features, epilepsy, neuropsychiatric diagnoses such as autism spectrum disorder, and cortical visual impairment. Although rare, we report early stroke and premature death with this condition. Conclusions: The spectrum of X-linked HNRNPH2-related disorders continues to expand as the allelic spectrum and identification of affected males increases.Grant support for L. Boyle provided by TL1TR001875.info:eu-repo/semantics/publishedVersio

Validation of spinal motion with the spine reposition sense device

© 2009 Petersen and Rundquist; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens

The second physical therapy summit on global health: developing an action plan to promote health in daily practice and reduce the burden of non-communicable diseases

Based on indicators that emerged from The First Physical Therapy Summit on Global Health (2007), the Second Summit (2011) identified themes to inform a global physical therapy action plan to integrate health promotion into practice across the World Confederation for Physical Therapy (WCPT) regions. Working questions were: (1) how well is health promotion implemented within physical therapy practice; and (2) how might this be improved across five target audiences (i.e. physical therapist practitioners, educators, researchers, professional body representatives, and government liaisons/consultants). In structured facilitated sessions, Summit representatives (n=32) discussed: (1) within WCPT regions, what is working and the challenges; and (2) across WCPT regions, what are potential directions using World CaféTM methodology. Commonalities outweighed differences with respect to strategies to advance health-focused physical therapy as a clinical competency across regions and within target audiences. Participants agreed that health-focused practice is a professional priority, and a strategic action plan was needed to develop it as a clinical competency. The action plan and recommendations largely paralleled the principles and objectives of the World Health Organization's non-communicable diseases action plan. A third Summit planned for 2015 will provide a mechanism for follow-up to evaluate progress in integrating health-focused physical therapy within the profession.info:eu-repo/semantics/acceptedVersio

The CTSA Consortium's Catalog of Assets for Translational and Clinical Health Research (CATCHR)

The 61 CTSA Consortium sites are home to valuable programs and infrastructure supporting translational science and all are charged with ensuring that such investments translate quickly to improved clinical care. Catalog of Assets for Translational and Clinical Health Research (CATCHR) is the Consortium's effort to collect and make available information on programs and resources to maximize efficiency and facilitate collaborations. By capturing information on a broad range of assets supporting the entire clinical and translational research spectrum, CATCHR aims to provide the necessary infrastructure and processes to establish and maintain an open‐access, searchable database of consortium resources to support multisite clinical and translational research studies. Data are collected using rigorous, defined methods, with the resulting information made visible through an integrated, searchable Web‐based tool. Additional easy‐to‐use Web tools assist resource owners in validating and updating resource information over time. In this paper, we discuss the design and scope of the project, data collection methods, current results, and future plans for development and sustainability. With increasing pressure on research programs to avoid redundancy, CATCHR aims to make available information on programs and core facilities to maximize efficient use of resources.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106893/1/cts12144.pd

Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of bladder carcinoma

Abstract The standard of care for most patients with non-muscle-invasive bladder cancer (NMIBC) is immunotherapy with intravesical Bacillus Calmette-Guérin (BCG), which activates the immune system to recognize and destroy malignant cells and has demonstrated durable clinical benefit. Urologic best-practice guidelines and consensus reports have been developed and strengthened based on data on the timing, dose, and duration of therapy from randomized clinical trials, as well as by critical evaluation of criteria for progression. However, these reports have not penetrated the community, and many patients do not receive appropriate therapy. Additionally, several immune checkpoint inhibitors have recently been approved for treatment of metastatic disease. The approval of immune checkpoint blockade for patients with platinum-resistant or -ineligible metastatic bladder cancer has led to considerations of expanded use for both advanced and, potentially, localized disease. To address these issues and others surrounding the appropriate use of immunotherapy for the treatment of bladder cancer, the Society for Immunotherapy of Cancer (SITC) convened a Task Force of experts, including physicians, patient advocates, and nurses, to address issues related to patient selection, toxicity management, clinical endpoints, as well as the combination and sequencing of therapies. Following the standard approach established by the Society for other cancers, a systematic literature review and analysis of data, combined with consensus voting was used to generate guidelines. Here, we provide a consensus statement for the use of immunotherapy in patients with bladder cancer, with plans to update these recommendations as the field progresses