Selenium, selenoprotein P, and oxidative stress levels in SARS-CoV-2 patients during illness and recovery

Background: This study aimed to assess tendency of oxidative stress in COVID-19 patients depending on severity. Methods: The study was conducted with 80 post-COVID-19 disease patients and 40 acutely ill patients. Content of selenium in blood plasma was detected by a fluorimetric method with di-amino-naphthalene using acidic hydrolysis. Selenoprotein P, malondialdehyde and 4-hydroxynonenal and their metabolite adducts were evaluated by spectrophotometric methods using commercial assay kits. Results: Obtained results showed that selenium content in blood for post-COVID-19 disease patients was of a similar lower norm for Latvian inhabitants. Selenium and seleno-protein P contents for acute patients were significantly decreased compared with post-COVID-19 disease patients. Conclusion: In conclusion, COVID-19 involves induction of antioxidant systems—in case of severe disease, patients have significantly low concentration of selenium, seleno-protein P and higher level of oxidative stress, which, in turn, confirms the more intense formation of free radicals in the body

Berries, the antioxidant sources of the boreal cold and arid regions

Chronic gastrointestinal diseases are mostly attached to inflammation as well as modified redox homeostasis. These diseases cause remarkable health problems in the northern regions of Europe, but as the climate becomes colder, the harvesting of fruit with notable antioxidant content becomes harder. In these regions, polyphenol-rich berries, which can handle the climate, may have pivotal role in the diet. The aim of our study was to determine antioxidant properties of watery extracts of blueberry, Vaccinium corymbosum L., bilberry, V. myrtillus L., and lingonberry, V. vitis-idaea L. that may have role in the redox homeostasis of the gastrointestinal region. Data show that these berries notably inhibit the lipid peroxidation, underpinned by reducing power, total polyphenol and ascorbic acid content. The study demonstrates that berries can play a remarkable role in northern European diet, especially when redox homeostasis is imbalanced

Selenium and antioxidant enzymes status in HCV/HIV patients supplemented with antioxidant cocktail

Background. In Latvia about 100.000 cases have been diagnosed as positive HCV, with up to 30% as HIV positive. Micronutrient deficiencies are common in HIV, both in early and late stages of the disease. Micronutrient deficiencies are common in HIV/AIDS, resulting from both malabsorption and virally-caused depletion. Selenium deficiency has also been documented in both HIV and AIDS patients in both plasma and red blood cells and to correlate with progression and mortality of HIV. Low selenium levels correlate with low glutathione peroxidase activity in HIV and AIDS. Observational studies have linked higher levels of selenium in the blood with higher CD4+ counts and reduced risk of mortality from HIV disease. Objective: To investigate the association, if there will be, between selenium and antioxidant enzymes status in HCV/HIV patients after antioxidants cocktail supplementation. Results: Low plasma selenium levels were found in patients with increased risks of HIV transmission. Similar trend was also shown when antioxidants enzymes were considered in these patients. Conclusion: In the search for modifiable risk factors to improve outcomes among HIV-infected subjects, multivitamin and trace elements have been used as a supplement. Our study shows that the role of micronutrients in HIV disease indicates that selenium deficiency may be considered as a risk factor in HIV. Adequate selenium/or antioxidants status may be beneficial for some but not all outcomes. Further studies are needed to better understand the role of selenium and antioxidants enzymes after supplementation.vokMyynti MTT Tietopalvelut 31600 Jokioine