651 research outputs found

    Regional specialised observatories networks in technological development and innovation exemplified by the Silesia Voivodship

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    The Regional Specialised Observatories Network is a systemic tool to encourage interdisciplinary cooperation between the key participants of the regional innovation system in order to build the competitive advantage of the region. The network responds to the region’s requirements by creating a modern tool to monitor the effects of the pro-technological development of the region in particular areas of technology, established in the Technological Development Strategy (TDS) for the Silesian Voivodship for the years 2010-2020, which is a constituent of the Regional Innovation Strategy. The observatory network will concentrate on collecting and processing specialised knowledge in the areas of technology in accord with TDS, monitoring technological and economic trends and assessment of the endogenous technological potential of the Silesian Voivodship. The network’s operation, through the link to the regional observatory as well as to national initiatives, will stimulate many forms of cooperation and contribute to the bonding of economic circles, innovators, science and research centres, the regional government and authorities responsible for drawing up and implementing development policy. The Regional Specialised Observatories Network is an open structure geared towards collecting, processing and publicising specialised knowledge, being a trustworthy source of data and information on technological areas in the region. The article presents the Network’s impact on identifying challenges and technological trends in reference to the region’s potential.Preparation and printing funded by the National Agency for Research and Development under project “Kreator Innowacyjności – wparcie dla Przedsiębiorczości akademickiej

    Stereotypes about the deaf and sign language in the thinking of special needs education students

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    Malwina Kocoń, Magdalena Skalny, Stereotypes about the deaf and sign language in the thinking of special needs education students. Interdisciplinary Contexts of Special Pedagogy, no. 24, Poznań 2019. Pp. 109-126. Adam Mickiewicz University Press. ISSN 2300-391X. DOI: https://doi.org/10.14746/ikps.2019.24.06 The article discusses the problems of deaf people, Polish sign language as well as Signed Polish (Manually-Coded Polish) in the context of stereotypes held by first year students of special needs education. The analysis of the results of empirical research indicates which of the stereotypes concerning deaf and sign language mentioned in the study are present in the thinking of the social group covered by the research and the frequency of their occurrence. It presents and explains terminological aspects regarding stereotypes and proposes postulates to eliminate negative stereotyping.Malwina Kocoń, Magdalena Skalny, Stereotypes about the deaf and sign language in the thinking of special needs education students. Interdisciplinary Contexts of Special Pedagogy, no. 24, Poznań 2019. Pp. 109-126. Adam Mickiewicz University Press. ISSN 2300-391X. DOI: https://doi.org/10.14746/ikps.2019.24.06 The article discusses the problems of deaf people, Polish sign language as well as Signed Polish (Manually-Coded Polish) in the context of stereotypes held by first year students of special needs education. The analysis of the results of empirical research indicates which of the stereotypes concerning deaf and sign language mentioned in the study are present in the thinking of the social group covered by the research and the frequency of their occurrence. It presents and explains terminological aspects regarding stereotypes and proposes postulates to eliminate negative stereotyping

    BXD recombinant inbred mice as a model to study neurotoxicity

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    BXD recombinant inbred (RI) lines represent a genetic reference population derived from a cross between C57BL/6J mice (B6) and DBA/2J mice (D2), which through meiotic recombination events possesses recombinant chromosomes containing B6 or D2 haplotype segments. The quantitative trait loci (QTLs) are the locations of segregating genetic polymorphisms and are fundamental to understanding genetic diversity in human disease susceptibility and severity. QTL mapping represents the typical approach for identifying naturally occurring polymorphisms that influence complex phenotypes. In this process, genotypic values at markers of known genomic locations are associated with phenotypic values measured in a segregating population. Indeed, BXD RI strains provide a powerful tool to study neurotoxicity induced by different substances. In this review, we describe the use of BXD RI lines to understand the underlying mechanisms of neurotoxicity in response to ethanol and cocaine, as well as metals and pesticide exposures. © 2021 by the authors. Licensee MDPI, Basel, Switzerland

    Diseño de hormigón durable

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    Some of the factors affecting the durability of modern concrete structures are discussed, with an emphasis on the problems caused by modern portland cements. This is followed by a description of some concrete durability issues of current interest, such as plastic shrinkage, seawater attack, and sulfate attack. The strategies for testing for durability are also discussed. It is concluded that, to produce durable concretes, a holistic approach to concrete construction must be adopted.Se discuten algunos de los factores que influyen en la durabilidad de las estructuras de hormigón modernas, haciendo énfasis en los problemas causados por el cemento Portland. A esto sigue una descripción de algunas cuestiones de interés general de la durabilidad del hormigón tales como la retracción plástica, el ataque por agua de mar y el ataque por sulfatos. Se discuten también las estrategias de los ensayos de durabilidad. Se concluye que para producir hormigones durables se debe adoptar un enfoque holístico de la construcción con hormigón

    The aging kidney—as influenced by heavy metal exposure and selenium supplementation

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    The aging process in the kidneys has been well studied. It is known that the glomerular filtration rate (GFR) declines with age in subjects older than 50–60 years. However, there is still insufficient knowledge regarding the response of the aged kidney to environmental toxicants such as mercury, cadmium, and lead. Here, we present a review on the functional decline and proposed mechanisms in the aging kidney as influenced by metal pollutants. Due to the prevalence of these toxicants in the environment, human exposure is nearly unavoidable. Further, it is well known that acute and chronic exposures to toxic metals may be detrimental to kidneys of normal adults, thus it may be hypothesized that exposure of individuals with reduced GFR will result in additional reductions in renal function. Individuals with compromised renal function, either from aging or from a combination of aging and disease, may be particularly susceptible to environmental toxicants. The available data appear to show an association between exposure to mercury, cadmium and/or lead and an increase in incidence and severity of renal disease in elderly individuals. Furthermore, some physiological thiols, as well as adequate selenium status, appear to exert a protective action. Further studies providing improved insight into the mechanisms by which nephrotoxic metals are handled by aging kidneys, as well as possibilities of therapeutic protection, are of utmost importance
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